ChemInform Abstract: Synthesis and Structure-Activity Relationships of M2-Selective Muscarinic Receptor Ligands in the 1-[4-(4-Arylsulfonyl)phenylmethyl]-4-(4-piperidinyl)-piperazine Family.

ChemInform ◽  
2010 ◽  
Vol 33 (25) ◽  
pp. no-no
Author(s):  
Stuart W. McCombie ◽  
et al. et al.
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure–Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update

2018 ◽  
Vol 61 (19) ◽  
pp. 8475-8503 ◽  
Author(s):  
Maria N. Modica ◽  
Enza Lacivita ◽  
Sebastiano Intagliata ◽  
Loredana Salerno ◽  
Giuseppe Romeo ◽  
...  
Keyword(s):  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Structure Activity

Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1

2007 ◽  
Vol 17 (11) ◽  
pp. 3023-3027 ◽  
Author(s):  
Ginny D. Ho ◽  
Ana Bercovici ◽  
Deen Tulshian ◽  
William J. Greenlee ◽  
Ahmad Fawzi ◽  
...  
Keyword(s):  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Nociceptin Receptor

Structure-Activity Relationships of Histamine H2 Receptor Ligands+

2004 ◽  
Vol 4 (9) ◽  
pp. 941-954 ◽  
Author(s):  
Stefan Dove ◽  
Sigurd Elz ◽  
Roland Seifert ◽  
Armin Buschauer
Keyword(s):  
Receptor Ligands ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity

ChemInform Abstract: Synthesis and Structure-Activity Relationships of Potent Retinoid X Receptor Ligands.

ChemInform ◽  
2010 ◽  
Vol 29 (4) ◽  
pp. no-no
Author(s):  
L. J. FARMER ◽  
S. JEONG ◽  
E. A. KALLEL ◽  
S. S. C. KOCH ◽  
G. E. CROSTON ◽  
...  
Keyword(s):  
Retinoid X Receptor ◽  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Structure Activity

ORL1 receptor ligands: Structure–activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones

2000 ◽  
Vol 10 (8) ◽  
pp. 831-834 ◽  
Author(s):  
Stephan Röver ◽  
Jürgen Wichmann ◽  
François Jenck ◽  
Geo Adam ◽  
Andrea M Cesura
Keyword(s):  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Orl1 Receptor ◽  
Structure Activity

An attempt at the hydrated imidazoline ring expansion (HIRE) of diarene-fused [1,4]diazepinones delivers selective dopamine D2 receptor ligands

Synthesis ◽  
2021 ◽  
Author(s):  
Sergey Grintsevich ◽  
Alexander V. Sapegin ◽  
Andrzej Bojarski ◽  
Beata Duszyńska ◽  
Mikhail Krasavin
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Ring Expansion ◽  
Side Chain ◽  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Dopamine D2 ◽  
Structure Activity ◽  
Imidazoline Ring ◽  
Selective Dopamine

Attempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) resulted in no ring expansion but rather 2-aminoethyl side chain expulsion. This seeming setback (setting the limitations to the HIRE methodology substrate scope) led to the discovery of selective dopamine D2 ligands with elements of structure-activity relationships.

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