ChemInform Abstract: Optical Activity of the 3-Aryl-4-hydroxycoumarin Isolated from Millettia griffoniana: Molecular Modeling and Total Synthesis.

ChemInform ◽  
2010 ◽  
Vol 33 (20) ◽  
pp. no-no
Author(s):  
Sebastien Combes ◽  
Jean-Pierre Finet ◽  
Didier Siri
Keyword(s):  
Molecular Modeling ◽  
Total Synthesis ◽  
Optical Activity

First total synthesis of marine derived anti-inflammatory natural product (-)-Herdmanine-D enabled by Steglich esterification

Synlett ◽  
2021 ◽  
Author(s):  
Pankaj Sharma ◽  
Nutan Sharma ◽  
Gunjan Kashyap ◽  
Sunita Bhagat
Keyword(s):  
Carboxylic Acid ◽  
Drug Development ◽  
Total Synthesis ◽  
Natural Product ◽  
Optical Activity ◽  
Marine Natural Product ◽  
Current Strategy ◽  
Synthetic Strategy ◽  
Steglich Esterification ◽  
Anti Inflammatory

An efficient and regioselective route for the first total synthesis of anti-inflammatory marine natural product (-)-Herdmanine-D has been described with an excellent overall yield of 18%. The key feature of the synthetic strategy includes Steglich esterification of regioselectively constructed 6-bromo-5-methoxy-1H-indole-3-carboxylic acid and L-Tyrosine. L-isomer was confirmed through measurement of optical activity. The current strategy paves the way for construction of diverse analogues of the title natural product for drug development.

scholarly journals Molecular Modeling, Total Synthesis, and Biological Evaluations of C9-Deoxy Bryostatin 1

2010 ◽  
Vol 49 (27) ◽  
pp. 4580-4584 ◽  
Author(s):  
Gary E. Keck ◽  
Yam B. Poudel ◽  
Arnab Rudra ◽  
Jeffrey C. Stephens ◽  
Noemi Kedei ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Total Synthesis ◽  
Bryostatin 1

Molecular Modeling, Total Synthesis, and Biological Evaluations of C9-Deoxy Bryostatin 1

2010 ◽  
Vol 122 (27) ◽  
pp. 4684-4688 ◽  
Author(s):  
Gary E. Keck ◽  
Yam B. Poudel ◽  
Arnab Rudra ◽  
Jeffrey C. Stephens ◽  
Noemi Kedei ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Total Synthesis ◽  
Bryostatin 1
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