ChemInform Abstract: Novel Steroidal Vinyl Fluorides as Inhibitors of Steroid C17(20) Lyase.

ChemInform ◽  
2010 ◽  
Vol 33 (20) ◽  
pp. no-no
Author(s):  
Joseph P. Burkhart ◽  
Philip M. Weintraub ◽  
Cynthia A. Gates ◽  
Robert J. Resvick ◽  
Roy J. Vaz ◽  
...  
Keyword(s):  
Vinyl Fluorides

Stereodivergent Alkyne Hydrofluorination Using a Simple Practical Reagent

2020 ◽  
Author(s):  
Rui Guo ◽  
Xiaotian Qi ◽  
Hengye Xiang ◽  
Paul Geaneoates ◽  
Ruihan Wang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Biologically Active ◽  
Dft Studies ◽  
Thermodynamic Control ◽  
Important Goal ◽  
Peptide Bonds ◽  
Metal Free ◽  
Vinyl Cation ◽  
E And Z Isomers ◽  
Vinyl Fluorides

Vinyl fluorides play an important role in drug development as they serve as bioisosteres for peptide bonds and are found in a range of biologically active molecules. The discovery of safe, general and practical procedures to prepare vinyl fluorides remains an important goal and challenge for synthetic chemistry. Here we introduce an inexpensive and easily-handled reagent and report simple, scalable, and metal-free protocols for the regioselective and stereodivergent hydrofluorination of alkynes to access both the E and Z isomers of vinyl fluorides. These conditions were suitable for a diverse collection of alkynes, including several highly-functionalized pharmaceutical derivatives. Mechanistic and DFT studies support C–F bond formation through a vinyl cation intermediate, with the (E)- and (Z)-hydrofluorination products forming under kinetic and thermodynamic control, respectively.<br>

ChemInform Abstract: The Preparation of α-Fluoro Sulfoxides and Vinyl Fluorides.

ChemInform ◽  
1988 ◽  
Vol 19 (5) ◽  
Author(s):  
S. T. PURRINGTON ◽  
J. H. PITTMAN
Keyword(s):  
Vinyl Fluorides

The Preparation of α-Fluorosulfoxides and Vinyl Fluorides

1987 ◽  
Vol 28 (34) ◽  
pp. 3901-3904 ◽  
Author(s):  
Suzanne T. Purrington ◽  
James H. Pittman
Keyword(s):  
Vinyl Fluorides

Electrochemical method to vinyl fluorides (II). Cathodic cleavage and carboxylation of 1-fluoro-2-(4-biphenylyl)vinyl phenyl sulphoxide in nonaqueous media

1995 ◽  
Vol 40 (7) ◽  
pp. 829-835 ◽  
Author(s):  
Akira Kunugi ◽  
Shinya Mori ◽  
Seiji Komatsu ◽  
Hiroshi Matsui ◽  
Hidemitsu Uno ◽  
...  
Keyword(s):  
Electrochemical Method ◽  
Nonaqueous Media ◽  
Vinyl Fluorides

ChemInform Abstract: A New Route to Steroidal Vinyl Fluorides.

ChemInform ◽  
2010 ◽  
Vol 25 (17) ◽  
pp. no-no
Author(s):  
R. BOHLMANN
Keyword(s):  
Vinyl Fluorides

Vinyl Fluorides: Competent Olefinic Counterparts in the Intramolecular Pauson–Khand Reaction

2019 ◽  
Vol 21 (8) ◽  
pp. 2569-2573 ◽  
Author(s):  
Raquel Román ◽  
Natalia Mateu ◽  
Inés López ◽  
Mercedes Medio-Simon ◽  
Santos Fustero ◽  
...  
Keyword(s):  
Vinyl Fluorides

ChemInform Abstract: Iridium Catalysts with Chiral Imidazole-Phosphine Ligands for Asymmetric Hydrogenation of Vinyl Fluorides and other Olefins.

ChemInform ◽  
2008 ◽  
Vol 39 (39) ◽  
Author(s):  
Paeivi Kaukoranta ◽  
Mattias Engman ◽  
Christian Hedberg ◽  
Jonas Bergquist ◽  
Pher G. Andersson
Keyword(s):  
Asymmetric Hydrogenation ◽  
Phosphine Ligands ◽  
Iridium Catalysts ◽  
Vinyl Fluorides

Intermolecular fluoroamination of allenes towards substituted vinyl fluorides

2020 ◽  
Vol 18 (44) ◽  
pp. 9044-9049
Author(s):  
Vibha Tiwari ◽  
Jacob T. Bingham ◽  
Shubham Vyas ◽  
Anand Singh
Keyword(s):  
Vinyl Fluorides

Allene difunctionalization: Selectfluor mediated intermolecular aminofluorination of allenes with triazole and tetrazole nucleophiles towards vinyl fluorides.

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