ChemInform Abstract: A Tandem Michael Addition Ring-Closure Route to the Metabotropic Receptor Ligand α-(Hydroxymethyl)glutamic Acid (IV) and Its γ-Alkylated Derivatives.

ChemInform ◽  
2010 ◽  
Vol 33 (16) ◽  
pp. no-no
Author(s):  
Jiazhong Zhang ◽  
Judith L. Flippen-Anderson ◽  
Alan P. Kozikowski
Keyword(s):  
Glutamic Acid ◽  
Michael Addition ◽  
Ring Closure ◽  
Metabotropic Receptor ◽  
Receptor Ligand

Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c]coumarins

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1589-1592 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Mahnaz Saraei ◽  
Reyhaneh Khoeiniha
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Ring Closure ◽  
Dehydration Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Tandem Process ◽  
First Time

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

A Highly Efficient Synthesis of Lamellarins K and L by the Michael Addition/Ring-Closure Reaction of Benzyldihydroisoquinoline Derivatives with Ethoxycarbonyl-β-nitrostyrenes

2004 ◽  
Vol 116 (7) ◽  
pp. 884-886 ◽  
Author(s):  
Poonsakdi Ploypradith ◽  
Chulabhorn Mahidol ◽  
Poolsak Sahakitpichan ◽  
Siriporn Wongbundit ◽  
Somsak Ruchirawat
Keyword(s):  
Michael Addition ◽  
Ring Closure ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
The Michael Addition

Enantioselective solution- and solid-phase synthesis of glutamic acid derivatives via Michael addition reactions

2001 ◽  
Vol 12 (6) ◽  
pp. 821-828 ◽  
Author(s):  
Martin J. O'Donnell ◽  
Francisca Delgado ◽  
Esteban Domı́nguez ◽  
Jesús de Blas ◽  
William L. Scott
Keyword(s):  
Glutamic Acid ◽  
Michael Addition ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Addition Reactions ◽  
Phase Synthesis ◽  
Glutamic Acid Derivatives

Highly Enantioselective Synthesis of (2S)-α-(Hydroxymethyl)-glutamic Acid by the Catalytic Michael Addition of 2-Naphthalen-1-yl-2-oxazoline-4-carboxylic Acidtert-Butyl Ester

2005 ◽  
Vol 7 (15) ◽  
pp. 3207-3209 ◽  
Author(s):  
Yeon-Ju Lee ◽  
Jihye Lee ◽  
Mi-Jeong Kim ◽  
Byeong-Seon Jeong ◽  
Jeong-Hee Lee ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Michael Addition ◽  
Butyl Ester ◽  
Enantioselective Synthesis
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