ChemInform Abstract: Erectones A and B, Two Dome-Shaped Polyprenylated Phloroglucinol Derivatives, from Hypericum erectum.

ChemInform ◽  
2010 ◽  
Vol 33 (14) ◽  
pp. no-no
Author(s):  
Tian-ying An ◽  
Li-hong Hu ◽  
Zhong-liang Chen ◽  
Keng-Yeow Sim
Keyword(s):  
Phloroglucinol Derivatives ◽  
Hypericum Erectum

Phloroglucinol derivatives as competitive inhibitors against thromboxane A2 and leukotriene D4 from Hypericum erectum

1991 ◽  
Vol 30 (8) ◽  
pp. 2559-2562 ◽  
Author(s):  
Masahiro Tada ◽  
Kazuhiro Chiba ◽  
Hirokazu Yamada ◽  
Hirokazu Maruyama
Keyword(s):  
Thromboxane A2 ◽  
Leukotriene D4 ◽  
Competitive Inhibitors ◽  
Phloroglucinol Derivatives ◽  
Hypericum Erectum

Erectones A and B, two dome-shaped polyprenylated phloroglucinol derivatives, from Hypericum erectum

2002 ◽  
Vol 43 (1) ◽  
pp. 163-165 ◽  
Author(s):  
Tian-ying An ◽  
Li-hong Hu ◽  
Zhong-liang Chen ◽  
Keng-Yeow Sim
Keyword(s):  
Phloroglucinol Derivatives ◽  
Hypericum Erectum

Polyprenylated phloroglucinol derivatives from Hypericum erectum

2002 ◽  
Vol 59 (4) ◽  
pp. 395-398 ◽  
Author(s):  
Tian-Ying An ◽  
Ming-De Shan ◽  
Li-Hong Hu ◽  
Shou-Jing Liu ◽  
Zhong-Liang Chen
Keyword(s):  
Phloroglucinol Derivatives ◽  
Hypericum Erectum

scholarly journals Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium

2008 ◽  
Vol 1 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Sara L. Crockett ◽  
Eva-Maria Wenzig ◽  
Olaf Kunert ◽  
Rudolf Bauer
Keyword(s):  
Phloroglucinol Derivatives ◽  
Anti Inflammatory

Prenylated phloroglucinol derivatives from Hypericum sampsonii

Fitoterapia ◽  
2012 ◽  
Vol 83 (8) ◽  
pp. 1540-1547 ◽  
Author(s):  
Wen-bo Xin ◽  
Xiao-hua Man ◽  
Cheng-jian Zheng ◽  
Min Jia ◽  
Yi-ping Jiang ◽  
...  
Keyword(s):  
Phloroglucinol Derivatives

scholarly journals Antifungal Agents: Design, Synthesis, Antifungal Activity and Molecular Docking of Phloroglucinol Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3116 ◽  
Author(s):  
Xingxing Teng ◽  
Yuanyuan Wang ◽  
Jinhua Gu ◽  
Peiqi Shi ◽  
Zhibin Shen ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antifungal Activity ◽  
Protein Binding ◽  
Binding Site ◽  
Antifungal Agents ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Protein Binding Site ◽  
Antifungal Activities ◽  
Phloroglucinol Derivatives

Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and investigated its antifungal activity as well as its intermediates. However, the results showed these compounds have low antifungal activity. In this study, in order to increase antifungal activities of phloroglucinol derivatives, we introduced antifungal pharmacophore allylamine into the methylphloroglucinol. Meanwhile, we remained C1–C4 acyl group in C-6 position of methylphloroglucinol using pseudoaspidinol as the lead compound to obtain novel phloroglucinol derivatives, synthesized 17 compounds, and evaluated antifungal activities on Trichophyton rubrum and Trichophyton mentagrophytes in vitro. Molecular docking verified their ability to combine the protein binding site. The results indicated that most of the compounds had strong antifungal activity, in which compound 17 were found to be the most active on Trichophyton rubrum with Minimum Inhibitory Concentration (MIC) of 3.05 μg/mL and of Trichophyton mentagrophytes with MIC of 5.13 μg/mL. Docking results showed that compounds had a nice combination with the protein binding site. These researches could lay the foundation for developing antifungal agents of clinical value.

New cytotoxic phloroglucinol derivatives from Agrimonia pilosa

Fitoterapia ◽  
2017 ◽  
Vol 118 ◽  
pp. 69-72 ◽  
Author(s):  
Lan Tang ◽  
Lulu Fu ◽  
Chenghua Lu ◽  
Xiaorong Hou ◽  
Weiguang Shan ◽  
...  
Keyword(s):  
Phloroglucinol Derivatives

Prenylflavonoids and Phloroglucinol Derivatives from Hops (Humulus lupulus)

2005 ◽  
Vol 68 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Feng Zhao ◽  
Yuki Watanabe ◽  
Hajime Nozawa ◽  
Akihiro Daikonnya ◽  
Keiji Kondo ◽  
...  
Keyword(s):  
Humulus Lupulus ◽  
Phloroglucinol Derivatives
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