ChemInform Abstract: Catalytic Enantioselective Synthesis of Secondary Alcohols Using C2-Symmetric Diamino Diol Ligands.

ChemInform ◽  
2010 ◽  
Vol 33 (12) ◽  
pp. no-no
Author(s):  
Biao Jiang ◽  
Yan Feng ◽  
Jian-Feng Hang
Keyword(s):  
Enantioselective Synthesis ◽  
Secondary Alcohols

Enantioselective synthesis of secondary alcohols in the presence of chiral ligands

Tetrahedron ◽  
1982 ◽  
Vol 38 (17) ◽  
pp. 2725-2727 ◽  
Author(s):  
L. Colombo ◽  
C. Gennari ◽  
G. Poli ◽  
C. Scolastico
Keyword(s):  
Enantioselective Synthesis ◽  
Chiral Ligands ◽  
Secondary Alcohols

Highly Enantioselective Synthesis of Secondary Alcohols using Triphenylborane

2004 ◽  
Vol 346 (7) ◽  
pp. 867-872 ◽  
Author(s):  
Jens Rudolph ◽  
Frank Schmidt ◽  
Carsten Bolm
Keyword(s):  
Enantioselective Synthesis ◽  
Secondary Alcohols

scholarly journals Highly Efficient Kinetic Resolution of Aryl-Alkenyl Alcohols by Ru-Catalyzed Hydrogen Transfer

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7475
Author(s):  
Yipeng You ◽  
Ming Yu Jin ◽  
Guanyu Tao ◽  
Xiangyou Xing
Keyword(s):  
Organic Synthesis ◽  
Hydrogen Transfer ◽  
Kinetic Resolution ◽  
Asymmetric Reduction ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Allylic Alcohols ◽  
Secondary Alcohols ◽  
Highly Efficient ◽  
Reduction Of Ketones

No matter through asymmetric reduction of ketones or kinetic resolution of secondary alcohols, enantioselective synthesis of the corresponding secondary alcohols is challenging when the two groups attached to the prochiral or chiral centers are spatially or electronically similar. For examples, dialkyl (sp3 vs. sp3), diaryl (sp2 vs. sp2), and aryl-alkenyl (sp2 vs. sp2) alcohols are difficult to produce with high enantioselectivities. By exploiting our recently developed Ru-catalysts of minimal stereogenicity, we reported herein a highly efficient kinetic resolution of aryl-alkenyl alcohols through hydrogen transfer. This method enabled such versatile chiral building blocks for organic synthesis as allylic alcohols, to be readily accessed with excellent enantiomeric excesses at practically useful conversions.

C3 Symmetric oxazolinyl ligand as catalyst in the enantioselective addition of diethylzinc to aldehydes

1997 ◽  
Vol 75 (6) ◽  
pp. 629-633 ◽  
Author(s):  
T.H. Chan ◽  
G.Z. Zheng
Keyword(s):  
Aromatic Aldehydes ◽  
Enantioselective Synthesis ◽  
Addition Reactions ◽  
Secondary Alcohols ◽  
Enantioselective Addition ◽  
Symmetric Ligands

The C3 symmetric oxazolinyl ligand 1 has been synthesized. Compound 1 catalyzed the addition of diethylzinc to aromatic aldehydes to give secondary alcohols with high enantiomeric excesses (up to 90%). Keywords: diethylzinc, enantioselective synthesis, C3 symmetric ligands, enantioselective addition reactions, oxazolinyl ligands.

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