ChemInform Abstract: Method Development and Optimization of Enantiomeric Separations Using Macrocyclic Glycopeptide Chiral Stationary Phases

ChemInform ◽  
2010 ◽  
Vol 32 (29) ◽  
pp. no-no
Author(s):  
Thomas E. Beesley ◽  
J. T. Lee ◽  
Andy X. Wang
Keyword(s):  
Method Development ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Enantiomeric Separations ◽  
Macrocyclic Glycopeptide ◽  
Abstract Method

scholarly journals Enantioselective Liquid Chromatographic Separations Using Macrocyclic Glycopeptide-Based Chiral Selectors

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3380
Author(s):  
Róbert Berkecz ◽  
Dániel Tanács ◽  
Antal Péter ◽  
István Ilisz
Keyword(s):  
Liquid Chromatography ◽  
Stationary Phases ◽  
Practical Importance ◽  
Food Additives ◽  
Chemical Properties ◽  
Chiral Stationary Phases ◽  
Glycopeptide Antibiotics ◽  
Enantiomeric Separations ◽  
Chiral Selectors ◽  
Macrocyclic Glycopeptide

Numerous chemical compounds of high practical importance, such as drugs, fertilizers, and food additives are being commercialized as racemic mixtures, although in most cases only one of the isomers possesses the desirable properties. As our understanding of the biological actions of chiral compounds has improved, the investigation of the pharmacological and toxicological properties has become more and more important. Chirality has become a major issue in the pharmaceutical industry; therefore, there is a continuous demand to extend the available analytical methods for enantiomeric separations and enhance their efficiency. Direct liquid chromatography methods based on the application of chiral stationary phases have become a very sophisticated field of enantiomeric separations by now. Hundreds of chiral stationary phases have been commercialized so far. Among these, macrocyclic glycopeptide-based chiral selectors have proved to be an exceptionally useful class of chiral selectors for the separation of enantiomers of biological and pharmacological importance. This review focuses on direct liquid chromatography-based enantiomer separations, applying macrocyclic glycopeptide-based chiral selectors. Special attention is paid to the characterization of the physico-chemical properties of these macrocyclic glycopeptide antibiotics providing detailed information on their applications published recently.

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