ChemInform Abstract: Novel Concepts in Directed Biaryl Synthesis. Part 88. Oxidative Aryl Coupling Reactions: A Biomimetic Approach to Configurationally Unstable or Axially Chiral Biaryl Natural Products and Related Bioactive Compounds.

ChemInform ◽  
2001 ◽  
Vol 32 (19) ◽  
pp. no-no
Author(s):  
Gerhard Bringmann ◽  
Stefan Tasler
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Coupling Reactions ◽  
Axially Chiral ◽  
Biomimetic Approach ◽  
Biaryl Synthesis

Axially Chiral Natural Products and Bioactive Compounds

2019 ◽  
pp. 611-656
Author(s):  
Paul A. Keller ◽  
Nicholas M. Butler ◽  
Patrick M. McCosker
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Axially Chiral

Formal Total Syntheses of Crocacin A-D

2005 ◽  
Vol 70 (10) ◽  
pp. 1696-1708 ◽  
Author(s):  
Magnus Besev ◽  
Christof Brehm ◽  
Alois Fürstner
Keyword(s):  
Natural Products ◽  
Aldol Reaction ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Total Syntheses ◽  
Cross Coupling Reactions ◽  
Palladium Catalyzed ◽  
The Common ◽  
Selective Addition

A concise route to the common polyketide fragment5of crocacin A-D (1-4) is presented which has previously been converted into all members of this fungicidal and cytotoxic family of dipeptidic natural products by various means. Our synthesis features asyn-selective titanium aldol reaction controlled by a valinol-derived auxiliary, a zinc-mediated, palladium-catalyzedanti-selective addition of propargyl mesylate10to the chiral aldehyde9, as well as a comparison of palladium-catalyzed Stille and Suzuki cross-coupling reactions for the formation of the diene moiety of the target.

Synthetic Strategies to Access Heteroatomic Spirocentres Embedded in Natural Products

Synthesis ◽  
2021 ◽  
Author(s):  
Michael P. Badart ◽  
Bill C. Hawkins
Keyword(s):  
Natural Products ◽  
Heterocyclic Compound ◽  
Chemical Space ◽  
Three Dimensional ◽  
Coupling Reactions ◽  
Conjugate Additions ◽  
Biological Targets ◽  
Compound Libraries ◽  
The Common ◽  
Significant Attention

AbstractThe spirocyclic motif is abundant in natural products and provides an ideal three-dimensional template to interact with biological targets. With significant attention historically expended on the synthesis of flat-heterocyclic compound libraries, methods to access the less-explored three-dimensional medicinal-chemical space will continue to increase in demand. Herein, we highlight by reaction class the common strategies used to construct the spirocyclic centres embedded in a series of well-studied natural products.1 Introduction2 Cycloadditions3 Palladium-Catalysed Coupling Reactions4 Conjugate Additions5 Imines, Aminals, and Hemiaminal Ethers6 Mannich-Type Reactions7 Oxidative Dearomatisation8 Alkylation9 Organometallic Additions10 Conclusions

Cross-coupling reactions towards the synthesis of natural products

2021 ◽  
Author(s):  
Shaheera Tabassum ◽  
Ameer Fawad Zahoor ◽  
Sajjad Ahmad ◽  
Razia Noreen ◽  
Samreen Gul Khan ◽  
...  
Keyword(s):  
Natural Products ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

2011 ◽  
Vol 111 (2) ◽  
pp. 563-639 ◽  
Author(s):  
Gerhard Bringmann ◽  
Tanja Gulder ◽  
Tobias A. M. Gulder ◽  
Matthias Breuning
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Axially Chiral

scholarly journals Chemical Diversity and Biological Activity of Secondary Metabolites Isolated from Indonesian Marine Invertebrates

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1898
Author(s):  
Fauzia Izzati ◽  
Mega Ferdina Warsito ◽  
Asep Bayu ◽  
Anggia Prasetyoputri ◽  
Akhirta Atikana ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Marine Natural Products ◽  
Biological Function ◽  
Marine Invertebrates ◽  
Biological Activities ◽  
Structural Diversity ◽  
Chemical Diversity ◽  
Soft Corals ◽  
High Chemical

Marine invertebrates have been reported to be an excellent resource of many novel bioactive compounds. Studies reported that Indonesia has remarkable yet underexplored marine natural products, with a high chemical diversity and a broad spectrum of biological activities. This review discusses recent updates on the exploration of marine natural products from Indonesian marine invertebrates (i.e., sponges, tunicates, and soft corals) throughout 2007–2020. This paper summarizes the structural diversity and biological function of the bioactive compounds isolated from Indonesian marine invertebrates as antimicrobial, antifungal, anticancer, and antiviral, while also presenting the opportunity for further investigation of novel compounds derived from Indonesian marine invertebrates.

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