ChemInform Abstract: Epothilones: Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug-Resistant Cell Lines and Tumors

ChemInform ◽  
2001 ◽  
Vol 32 (12) ◽  
pp. no-no
Author(s):  
Christina R. Harris ◽  
Aaron Balog ◽  
Kenneth Savin ◽  
Samuel J. Danishefsky ◽  
Ting Chao Chou ◽  
...  
Keyword(s):  
Cell Lines ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Stabilizing Agents ◽  
Enhanced Activity

scholarly journals Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale

2019 ◽  
Vol 63 (3) ◽  
pp. 1434-1439 ◽  
Author(s):  
Lyn M. Huff ◽  
Sachi Horibata ◽  
Robert W. Robey ◽  
Matthew D. Hall ◽  
Michael M. Gottesman
Keyword(s):  
Cell Lines ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Mycoplasma Infection ◽  
Cautionary Tale

Probing daunorubicin accumulation defects in non-P-glycoprotein expressing multidrug-resistant cell lines using digitonin

1992 ◽  
Vol 50 (6) ◽  
pp. 906-911 ◽  
Author(s):  
C. H. M. Versantvoort ◽  
H. J. Broxterman ◽  
N. Feller ◽  
H. Dekker ◽  
C. M. Kuiper ◽  
...  
Keyword(s):  
Cell Lines ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
P Glycoprotein

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

Nature ◽  
1985 ◽  
Vol 316 (6031) ◽  
pp. 820-823 ◽  
Author(s):  
Norbert Kartner ◽  
Deanna Evernden-Porelle ◽  
Grace Bradley ◽  
Victor Ling
Keyword(s):  
Monoclonal Antibodies ◽  
Cell Lines ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
P Glycoprotein

Identification of protein kinase C subspecies in wild-type and multidrug-resistant cell lines

1993 ◽  
Vol 21 (4) ◽  
pp. 378S-378S
Author(s):  
James A. L. Fenton ◽  
Alex Paton ◽  
Nigel Groome ◽  
J. Roger Warr ◽  
Martin G. Rumsby
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Lines ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Wild Type ◽  
Kinase C

Structural Determinants of Phenoxazine Type Compounds Required to Modulate the Accumulation of Vinblastine and Vincristine in Multidrug-Resistant Cell Lines

1990 ◽  
Vol 2 (7) ◽  
pp. 249-259 ◽  
Author(s):  
Kuntebommanahalli N. Thimmaiah ◽  
Julie K. Horton ◽  
Xiao-dong Qian ◽  
William T. Beck ◽  
Janet A. Houghton ◽  
...  
Keyword(s):  
Cell Lines ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Structural Determinants

scholarly journals Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Benjamin Wiench ◽  
Tolga Eichhorn ◽  
Malte Paulsen ◽  
Thomas Efferth
Keyword(s):  
Cell Cycle ◽  
Cancer Cells ◽  
Cell Lines ◽  
Inflammatory Diseases ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Live Cells ◽  
Anticancer Activities ◽  
Cycle Arrest ◽  
Therapy Success

Chemotherapy is a mainstay of cancer treatment. Due to increased drug resistance and the severe side effects of currently used therapeutics, new candidate compounds are required for improvement of therapy success. Shikonin, a natural naphthoquinone, was used in traditional Chinese medicine for the treatment of different inflammatory diseases and recent studies revealed the anticancer activities of shikonin. We found that shikonin has strong cytotoxic effects on 15 cancer cell lines, including multidrug-resistant cell lines. Transcriptome-wide mRNA expression studies showed that shikonin induced genetic pathways regulating cell cycle, mitochondrial function, levels of reactive oxygen species, and cytoskeletal formation. Taking advantage of the inherent fluorescence of shikonin, we analyzed its uptake and distribution in live cells with high spatial and temporal resolution using flow cytometry and confocal microscopy. Shikonin was specifically accumulated in the mitochondria, and this accumulation was associated with a shikonin-dependent deregulation of cellular Ca2+and ROS levels. This deregulation led to a breakdown of the mitochondrial membrane potential, dysfunction of microtubules, cell-cycle arrest, and ultimately induction of apoptosis. Seeing as both the metabolism and the structure of mitochondria show marked differences between cancer cells and normal cells, shikonin is a promising candidate for the next generation of chemotherapy.

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