ChemInform Abstract: Ichthyotoxic Phloroglucinol Derivatives from Dryopteris fragrans and Their Antitumor Promoting Activity.

ChemInform ◽  
2000 ◽  
Vol 31 (52) ◽  
pp. no-no
Author(s):  
Hideyuki Ito ◽  
Takashi Muranaka ◽  
Kazuko Mori ◽  
Zhe-Xiong Jin ◽  
Harukuni Tokuda ◽  
...  
Keyword(s):  
Phloroglucinol Derivatives ◽  
Dryopteris Fragrans

Chemotaxonomic investigations on Dryopteris fragrans

1971 ◽  
Vol 49 (6) ◽  
pp. 989-992 ◽  
Author(s):  
C.-J. Widén ◽  
D. M. Britton
Keyword(s):  
Chemical Variability ◽  
Phloroglucinol Derivatives ◽  
Dryopteris Fragrans

The phloroglucinol derivatives in four collections of Dryopteris fragrans var. remotiuscula Komarov from Finland, Ontario, and Newfoundland were investigated. The collections from two localities in Ontario gave different results, which indicate either chemical variability in the variety, or the possibility that var. remotiuscula in Ontario might be re-evaluated.

scholarly journals Ichthyotoxic Phloroglucinol Derivatives from Dryopteris fragrans and Their Anti-tumor Promoting Activity.

2000 ◽  
Vol 48 (8) ◽  
pp. 1190-1195 ◽  
Author(s):  
Hideyuki ITO ◽  
Takashi MURANAKA ◽  
Kazuko MORI ◽  
Zhe-Xiong JIN ◽  
Harukuni TOKUDA ◽  
...  
Keyword(s):  
Phloroglucinol Derivatives ◽  
Dryopteris Fragrans

scholarly journals Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium

2008 ◽  
Vol 1 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Sara L. Crockett ◽  
Eva-Maria Wenzig ◽  
Olaf Kunert ◽  
Rudolf Bauer
Keyword(s):  
Phloroglucinol Derivatives ◽  
Anti Inflammatory

Prenylated phloroglucinol derivatives from Hypericum sampsonii

Fitoterapia ◽  
2012 ◽  
Vol 83 (8) ◽  
pp. 1540-1547 ◽  
Author(s):  
Wen-bo Xin ◽  
Xiao-hua Man ◽  
Cheng-jian Zheng ◽  
Min Jia ◽  
Yi-ping Jiang ◽  
...  
Keyword(s):  
Phloroglucinol Derivatives

Overexpression of Df4CL1 from Dryopteris fragrans Enhances Flavonoids and Lignin Production in Transgenic Tobacco

2021 ◽  
Vol 68 (1) ◽  
pp. 110-117
Author(s):  
Sh. Li ◽  
Y. Chang ◽  
P. lin Teoh ◽  
D. Wang ◽  
J. Mo ◽  
...  
Keyword(s):  
Transgenic Tobacco ◽  
Dryopteris Fragrans

scholarly journals Antifungal Agents: Design, Synthesis, Antifungal Activity and Molecular Docking of Phloroglucinol Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3116 ◽  
Author(s):  
Xingxing Teng ◽  
Yuanyuan Wang ◽  
Jinhua Gu ◽  
Peiqi Shi ◽  
Zhibin Shen ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antifungal Activity ◽  
Protein Binding ◽  
Binding Site ◽  
Antifungal Agents ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Protein Binding Site ◽  
Antifungal Activities ◽  
Phloroglucinol Derivatives

Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and investigated its antifungal activity as well as its intermediates. However, the results showed these compounds have low antifungal activity. In this study, in order to increase antifungal activities of phloroglucinol derivatives, we introduced antifungal pharmacophore allylamine into the methylphloroglucinol. Meanwhile, we remained C1–C4 acyl group in C-6 position of methylphloroglucinol using pseudoaspidinol as the lead compound to obtain novel phloroglucinol derivatives, synthesized 17 compounds, and evaluated antifungal activities on Trichophyton rubrum and Trichophyton mentagrophytes in vitro. Molecular docking verified their ability to combine the protein binding site. The results indicated that most of the compounds had strong antifungal activity, in which compound 17 were found to be the most active on Trichophyton rubrum with Minimum Inhibitory Concentration (MIC) of 3.05 μg/mL and of Trichophyton mentagrophytes with MIC of 5.13 μg/mL. Docking results showed that compounds had a nice combination with the protein binding site. These researches could lay the foundation for developing antifungal agents of clinical value.

New cytotoxic phloroglucinol derivatives from Agrimonia pilosa

Fitoterapia ◽  
2017 ◽  
Vol 118 ◽  
pp. 69-72 ◽  
Author(s):  
Lan Tang ◽  
Lulu Fu ◽  
Chenghua Lu ◽  
Xiaorong Hou ◽  
Weiguang Shan ◽  
...  
Keyword(s):  
Phloroglucinol Derivatives

Prenylflavonoids and Phloroglucinol Derivatives from Hops (Humulus lupulus)

2005 ◽  
Vol 68 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Feng Zhao ◽  
Yuki Watanabe ◽  
Hajime Nozawa ◽  
Akihiro Daikonnya ◽  
Keiji Kondo ◽  
...  
Keyword(s):  
Humulus Lupulus ◽  
Phloroglucinol Derivatives

Role of mitochondria in the leishmanicidal effects and toxicity of acyl phloroglucinol derivatives: nemorosone and guttiferone A

Parasitology ◽  
2015 ◽  
Vol 142 (9) ◽  
pp. 1239-1248 ◽  
Author(s):  
LIANET MONZOTE ◽  
ALEXANDRA LACKOVA ◽  
KATRIN STANIEK ◽  
OSMANY CUESTA-RUBIO ◽  
LARS GILLE
Keyword(s):  
Mitochondrial Respiratory Chain ◽  
Peritoneal Macrophages ◽  
Complex Iii ◽  
Specific Inhibition ◽  
Mitochondrial Superoxide ◽  
Phloroglucinol Derivatives ◽  
Succinate:Ubiquinone Oxidoreductase ◽  
Species Specific ◽  
Mammalian Toxicity

SUMMARYNemorosone (Nem) and guttiferone A (GutA) are acyl phloroglucinol derivatives (APD) that are present in different natural products. For both compounds anti-cancer and anti-microbial properties have been reported. In particular, an anti-leishmanial activity of both compounds was demonstrated. The aim of this study was to explore the possible role of mitochondria in the anti-leishmanial activity of Nem and GutA in comparison with their action on mammalian mitochondria. Both APD inhibited the growth of promastigotes ofLeishmania tarentolae(LtP) with half maximal inhibitory concentration (IC50) values of 0·67 ± 0·17 and 6·2 ± 2·6μm; while IC50values for cytotoxicity against peritoneal macrophages from BALB/c mice were of 29·5 ± 3·7 and 9·2 ± 0·9μm, respectively. Nemorosone strongly inhibited LtP oxygen consumption, caused species-specific inhibition (P< 0·05) of succinate:ubiquinone oxidoreductase (complex II) from LtP-mitochondria and significantly increased (P< 0·05) the mitochondrial superoxide production. In contrast, GutA caused only a moderate reduction of respiration in LtP and triggered less superoxide radical production in LtP compared with Nem. In addition, GutA inhibited mitochondrial complex III in bovine heart submitochondrial particles, which is possibly involved in its mammalian toxicity. Both compounds demonstrated at low micromolar concentrations an effect on the mitochondrial membrane potential in LtP. The present study suggests that Nem caused its anti-leishmanial action due to specific inhibition of complexes II/III of mitochondrial respiratory chain ofLeishmaniaparasites that could be responsible for increased production of reactive oxygen species that triggers parasite death.

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