ChemInform Abstract: Enantioselective Syntheses of 1-Carbacephalosporins from Chemoenzymically Derived β-Hydroxy-α-Amino Acids: Applications to the Total Synthesis of Carbacephem Antibiotic Loracarbef.

ChemInform ◽  
2000 ◽  
Vol 31 (47) ◽  
pp. no-no
Author(s):  
Tony Y. Zhang ◽  
et al. et al.
Keyword(s):  
Amino Acids ◽  
Total Synthesis ◽  
Enantioselective Syntheses

Enantioselective Syntheses of 1-Carbacephalosporins from Chemoenzymically Derived β-Hydroxy-α-Amino Acids: Applications to the Total Synthesis of Carbacephem Antibiotic Loracarbef

Tetrahedron ◽  
2000 ◽  
Vol 56 (31) ◽  
pp. 5667-5677 ◽  
Author(s):  
Billy G Jackson ◽  
Steve W Pedersen ◽  
Jack W Fisher ◽  
Jerry W Misner ◽  
John P Gardner ◽  
...  
Keyword(s):  
Amino Acids ◽  
Total Synthesis ◽  
Enantioselective Syntheses

scholarly journals New cyclization reactions in organic syntheses

2002 ◽  
Vol 74 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Iwao Ojima
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Total Synthesis ◽  
Cyclization Reactions ◽  
Organic Syntheses ◽  
Carbocyclic Compounds ◽  
Efficient Construction ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Recent development in the transition metal-catalyzed cyclization reactions for organic syntheses in the author's laboratories is summarized, which includes (i) novel silylcarbocyclizations (SiCaCs) and carbonylative carbotricyclizations, (ii) intramolecular silylformylations and desymmerization of siloxydiynes by sequential double silylformylation, (iii) efficient total synthesis of (+)-prosopinine, (iv) enantioselective desymmetrization of aminodienes, and (iv) new and efficient routes to 1-azabicyclo[x.y.0]alkane amino acids. All these processes are catalyzed by Rh or Rh­Co complexes, and useful for rapid and efficient construction of a variety of heterocyclic and carbocyclic compounds. Mechanisms of these new carbocyclization and cyclohydrocarbonylation reactions are also discussed.

scholarly journals Enantioselective total synthesis of decytospolide A and decytospolide B using an Achmatowicz reaction

2018 ◽  
Vol 16 (33) ◽  
pp. 5979-5986 ◽  
Author(s):  
Arun K. Ghosh ◽  
Hannah M. Simpson ◽  
Anne M. Veitschegger
Keyword(s):  
Total Synthesis ◽  
Transfer Hydrogenation ◽  
Enantioselective Total Synthesis ◽  
Key Steps ◽  
Enantioselective Syntheses

Enantioselective syntheses of decytospolides are described using an Achmatowicz rearrangement, transfer hydrogenation and Friedel–Crafts acylation as the key steps.

ChemInform Abstract: Stereoselective Total Synthesis of Topographically Constrained Designer Amino Acids: 2′,6′-Dimethyl-β-methyltyrosines.

ChemInform ◽  
2010 ◽  
Vol 26 (29) ◽  
pp. no-no
Author(s):  
X. QIAN ◽  
K. C. RUSSELL ◽  
L. W. BOTEJU ◽  
V. J. HRUBY
Keyword(s):  
Amino Acids ◽  
Total Synthesis

scholarly journals N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds

2019 ◽  
Vol 15 ◽  
pp. 1722-1757
Author(s):  
Iwona E Głowacka ◽  
Aleksandra Trocha ◽  
Andrzej E Wróblewski ◽  
Dorota G Piotrowska
Keyword(s):  
Amino Acids ◽  
Natural Products ◽  
Natural Compounds ◽  
Review Article ◽  
Chiral Auxiliary ◽  
Biologically Relevant ◽  
Alternative Approaches ◽  
Approved Drugs ◽  
Enantioselective Syntheses ◽  
New Procedures

Since Garner’s aldehyde has several drawbacks, first of all is prone to racemization, alternative three-carbon chirons would be of great value in enantioselective syntheses of natural compounds and/or drugs. This review article summarizes applications of N-(1-phenylethyl)aziridine-2-carboxylates, -carbaldehydes and -methanols in syntheses of approved drugs and potential medications as well as of natural products mostly alkaloids but also sphingoids and ceramides and their 1- and 3-deoxy analogues and several hydroxy amino acids and their precursors. Designed strategies provided new procedures to several drugs and alternative approaches to natural products and proved efficiency of a 2-substituted N-(1-phenylethyl)aziridine framework as chiron bearing a chiral auxiliary.

ChemInform Abstract: Total Synthesis of Amino Acids in Ultra Vacuum.

ChemInform ◽  
1989 ◽  
Vol 20 (30) ◽  
Author(s):  
F. M. DEVIENNE ◽  
J. GOUDOUR
Keyword(s):  
Amino Acids ◽  
Total Synthesis
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