ChemInform Abstract: Targeting Drugs to the Brain by Redox Chemical Delivery Systems

ChemInform ◽  
2000 ◽  
Vol 31 (45) ◽  
pp. no-no
Author(s):  
Laszlo Prokai ◽  
Katalin Prokai-Tatrai ◽  
Nicholas Bodor
Keyword(s):  
Delivery Systems ◽  
Chemical Delivery Systems ◽  
The Brain

New developments in redox chemical delivery systems by means of 1,4-dihydroquinoline-based targetor: Application to galantamine delivery to the brain

2014 ◽  
Vol 81 ◽  
pp. 218-226 ◽  
Author(s):  
Mihaela-Liliana Ţînţaş ◽  
Lénaïg Foucout ◽  
Sylvain Petit ◽  
Sylvain Oudeyer ◽  
Fabienne Gourand ◽  
...  
Keyword(s):  
Delivery Systems ◽  
New Developments ◽  
Chemical Delivery Systems ◽  
The Brain

Targeting drugs to the brain by redox chemical delivery systems

2000 ◽  
Vol 20 (5) ◽  
pp. 367-416 ◽  
Author(s):  
Laszlo Prokai ◽  
Katalin Prokai-Tatrai ◽  
Nicholas Bodor
Keyword(s):  
Delivery Systems ◽  
Chemical Delivery Systems ◽  
The Brain

Alzheimer’s disease and its related Dementia types: A review on their management via nanotechnology based therapeutic strategies

2021 ◽  
Vol 18 ◽  
Author(s):  
Panoraia I. Siafaka ◽  
Gökce Mutlu ◽  
Neslihan Üstündağ Okur
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Daily Routine ◽  
Mixed Dementia ◽  
The Brain

Background: Dementia and its related types such as Alzheimer’s disease, vascular dementia and mixed dementia belong to brain associated diseases, resulting in long-term progressive memory loss. These diseases are so severe that can affect a person's daily routine. Up to date, treatment of de- mentias is still an unmet challenge due to their complex pathophysiology and unavailable efficient pharmacological approaches. The use of nanotechnology based pharmaceutical products could possibly improve the management of dementia given that nanocarriers could more efficiently deliver drugs to the brain. Objective: The objective of this study is to provide the current nanotechnology based drug delivery systems for the treatment of various dementia types. In addition, the current diagnosis biomarkers for the mentioned dementia types along with their available pharmacological treatment are being dis- cussed. Method: An extensive review of the current nanosystems such as brain drug delivery systems against Alzheimer’s disease, vascular dementia and mixed dementia was performed. Moreover, nan- otheranostics as possible imaging markers for such dementias were also reported. Results: The field of nanotechnology is quite advantageous for targeting dementia given that nanoscale drug delivery systems easily penetrate the blood brain barrier and circulate in the body for prolonged time. These nanoformulations consist of polymeric nanoparticles, solid lipid nanoparticles, nanostruc- tured lipid carriers, microemulsions, nanoemulsions, and liquid crystals. The delivery of the nan- otherapeutics can be achieved via various administration routes such as transdermal, injectable, oral, and more importantly, through the intranasal route. Nonetheless, the nanocarriers are mostly limited to Alzheimer’s disease targeting; thus, nanocarriers for other types of dementia should be developed. Conclusion: To conclude, understanding the mechanism of neurodegeneration and reviewing the cur- rent drug delivery systems for Alzheimer’s disease and other dementia types are significant for medical and pharmaceutical society to produce efficient therapeutic choices and novel strategies based on mul- tifunctional and biocompatible nanocarriers, which can deliver the drug sufficiently into the brain.

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