ChemInform Abstract: Synthesis of Oligodeoxyribonucleotide Bearing 2′-S-Alkyl Residue and Its Effect on the Duplex Stability.

ChemInform ◽  
2000 ◽  
Vol 31 (44) ◽  
pp. no-no
Author(s):  
Hiroaki Ozaki ◽  
Yuichi Sato ◽  
Sadaji Azuma ◽  
Hiroaki Sawai
Keyword(s):  
Duplex Stability ◽  
Alkyl Residue

Synthesis of Oligodeoxyribonucleotide Bearing 2′-S-Alkyl Residue and its Effect on the Duplex Stability

2000 ◽  
Vol 19 (3) ◽  
pp. 593-601 ◽  
Author(s):  
Hiroaki Ozaki ◽  
Yuichi Sato ◽  
Sadaji Azuma ◽  
Hiroaki Sawai
Keyword(s):  
Duplex Stability ◽  
Alkyl Residue

Postsynthetic Modification of Oligonucleotides with Imidazophenazine Dye and its Effect on Duplex Stability

2011 ◽  
Vol 30 (7-8) ◽  
pp. 585-596 ◽  
Author(s):  
Larysa Dubey ◽  
Olga Ryazanova ◽  
Victor Zozulya ◽  
Dmytro Fedoryak ◽  
Igor Dubey
Keyword(s):  
Postsynthetic Modification ◽  
Duplex Stability

Influence of Local Duplex Stability andN6-Methyladenine on Uracil Recognition by Mismatch-Specific Uracil-DNA Glycosylase (Mug)

2002 ◽  
Vol 15 (12) ◽  
pp. 1595-1601 ◽  
Author(s):  
Victoria Valinluck ◽  
Pingfang Liu ◽  
Artur Burdzy ◽  
Junichi Ryu ◽  
Lawrence C. Sowers
Keyword(s):  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Duplex Stability

scholarly journals Single Molecule Investigation of Ag+ Interactions with Single Cytosine-, Methylcytosine- and Hydroxymethylcytosine-Cytosine Mismatches in a Nanopore

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Yong Wang ◽  
Bin-Quan Luan ◽  
Zhiyu Yang ◽  
Xinyue Zhang ◽  
Brandon Ritzo ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Binding Site ◽  
Single Molecule ◽  
Metal Ion ◽  
Detection Method ◽  
Direct Detection ◽  
Alpha Hemolysin ◽  
Duplex Stability ◽  
Dynamics Simulations ◽  
Direct Detection Method

Abstract Both cytosine-Ag-cytosine interactions and cytosine modifications in a DNA duplex have attracted great interest for research. Cytosine (C) modifications such as methylcytosine (mC) and hydroxymethylcytosine (hmC) are associated with tumorigenesis. However, a method for directly discriminating C, mC and hmC bases without labeling, modification and amplification is still missing. Additionally, the nature of coordination of Ag+ with cytosine-cytosine (C-C) mismatches is not clearly understood. Utilizing the alpha-hemolysin nanopore, we show that in the presence of Ag+, duplex stability is most increased for the cytosine-cytosine (C-C) pair, followed by the cytosine-methylcytosine (C-mC) pair and the cytosine-hydroxymethylcytosine (C-hmC) pair, which has no observable Ag+ induced stabilization. Molecular dynamics simulations reveal that the hydrogen-bond-mediated paring of a C-C mismatch results in a binding site for Ag+. Cytosine modifications (such as mC and hmC) disrupted the hydrogen bond, resulting in disruption of the Ag+ binding site. Our experimental method provides a novel platform to study the metal ion-DNA interactions and could also serve as a direct detection method for nucleobase modifications.

Antisense Recognition of the HER-2 mRNA:  Effects of Phosphorothioate Substitution and Polyamines on DNA·RNA, RNA·RNA, and DNA·DNA Duplex Stability†

Biochemistry ◽  
2005 ◽  
Vol 44 (1) ◽  
pp. 303-312 ◽  
Author(s):  
Sripriya Venkiteswaran ◽  
Veena Vijayanathan ◽  
Akira Shirahata ◽  
Thresia Thomas ◽  
T. J. Thomas
Keyword(s):  
Duplex Stability ◽  
Her 2

Enhanced H-bonding and π-stacking in DNA: a potent duplex-stabilizing and mismatch sensing nucleobase analogue

2014 ◽  
Vol 5 (10) ◽  
pp. 3836-3844 ◽  
Author(s):  
Chenguang Lou ◽  
Andre Dallmann ◽  
Pietro Marafini ◽  
Rachel Gao ◽  
Tom Brown
Keyword(s):  
Electrostatic Attraction ◽  
Dna Duplex ◽  
Π Stacking ◽  
Duplex Stability

Combining enhanced π-stacking, H-bonding and electrostatic attraction in a single C-monomer greatly increases DNA duplex stability and massively destabilises mismatches.

Lewis Acid Mediated Vinyl-Transfer Reaction of Alkynes toN-Alkylimines by Using theN-Alkyl Residue as a Sacrificial Hydrogen Donor

2013 ◽  
Vol 19 (42) ◽  
pp. 14263-14270 ◽  
Author(s):  
Chandi C. Malakar ◽  
Sara Stas ◽  
Wouter Herrebout ◽  
Kourosch Abbaspour Tehrani
Keyword(s):  
Lewis Acid ◽  
Transfer Reaction ◽  
Hydrogen Donor ◽  
Alkyl Residue
Sign in / Sign up

Export Citation Format

Share Document