ChemInform Abstract: New Highly Potent Dipeptidic Growth Hormone Secretagogues with Low Molecular Weight.

ChemInform ◽  
2000 ◽  
Vol 31 (44) ◽  
pp. no-no
Author(s):  
Bernd Peschke ◽  
Michael Ankersen ◽  
Thomas Kruse Hanson ◽  
Birgit Sehested Hansen ◽  
Jesper Lau ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Growth Hormone ◽  
Low Molecular Weight ◽  
Growth Hormone Secretagogues

The effect of a Rhizoctonia solani phytotoxin on potatoes

1976 ◽  
Vol 54 (22) ◽  
pp. 2536-2540 ◽  
Author(s):  
J. A. Frank ◽  
S. K. Francis
Keyword(s):  
Molecular Weight ◽  
Growth Hormone ◽  
Rhizoctonia Solani ◽  
Liquid Culture ◽  
Phenylacetic Acid ◽  
Low Molecular Weight ◽  
Leaf Margin ◽  
Disease Symptoms ◽  
Low Concentrations ◽  
Root Necrosis

Rhizoctonia solani produces a nonenzymatic, low-molecular-weight phytotoxin in liquid culture. Many of the disease symptoms on potato attributed to this pathogen can be induced with this toxin. These include root necrosis and stolon pruning, leaf curling, stunting, and leaf margin chlorosis. In cases of extreme susceptibility, the plants could be killed within 1 week. The toxin has similar effects on radish, beet, and corn seedlings and acts as a growth hormone in low concentrations. A technique was designed to evaluate potato clones for their resistance to the root necrosis phase of the disease syndrome. With additional purification, the toxic fraction was identified as phenylacetic acid and its metahydroxylated derivative.

Amino acids enhance renal tubular absorption of the los-molecular-weight proteins insulin and growth hormone

1982 ◽  
Vol 242 (6) ◽  
pp. F745-F749
Author(s):  
R. Rabkin ◽  
T. I. Gottheiner ◽  
T. S. Tsao
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Growth Hormone ◽  
Human Growth ◽  
Metabolic Effect ◽  
Low Molecular Weight ◽  
Insulin Absorption ◽  
Tubular Absorption ◽  
Renal Tubular ◽  
Isolated Rat

The effect of amino acids(AA) on the tubular absorption of low-molecular-weight (LMW) proteins was studied in isolated rat kidneys. Kidneys were perfused with an albumin-electrolyte solution that contained insulin or human growth hormone (hGH) and, unless otherwise stated, the following L-amino acids: glycine, isoleucine, serine, alanine, methionine, proline, arginine, and aspartic acid. In kidneys perfused without AA, fractional urinary insulin clearance (FCi) averaged 7.4 +/- 1.54%, whereas in the presence of multiple AA the FCi was significantly lower (0.68 +/- 0.2%, P less than 0.01). Addition of glycine or alpha-aminoisobutyric acid (AIB) alone also reduced the FCi significantly (1.79 +/- 0.66 and 1.59 +/-1.06%, respectively). By contrast, perfusion with the other AA individually did not alter the FCi. The fractional urinary hGH clearance was also significantly lower in kidneys perfused with multiple AA (0.94 +/- 0.47%) than in those perfused without AA (9.07 +/- 1.2%). We conclude that tubular absorption of filtered insulin and hGH is enhanced by the presence of AA. The mechanism is unclear, but enhancement of insulin absorption can be produced by glycine and AIB alone. This raises the possibility of a link between the absorption of insulin and the glycine and AIB shared transport system, but excludes a primary metabolic effect because AIB is nonmetabolizable.

Purification from Human Pregnancy Serum of a Low Molecular Weight Mitogen Similar to Placental Lactogen and Growth Hormone

1991 ◽  
Vol 197 (4) ◽  
pp. 441-449
Author(s):  
R. D. Kineman ◽  
E. E. Bullesbach ◽  
C. Schwabe ◽  
K. P. Boggs ◽  
L. S. Frawley
Keyword(s):  
Molecular Weight ◽  
Growth Hormone ◽  
Placental Lactogen ◽  
Low Molecular Weight ◽  
Human Pregnancy

A high-performance oil-free backing pump for electron microscopes

1978 ◽  
Vol 36 (1) ◽  
pp. 110-111
Author(s):  
G.K.W. Balkau ◽  
E. Bez ◽  
J.L. Farrant
Keyword(s):  
Molecular Weight ◽  
Electron Microscope ◽  
Hot Spots ◽  
High Performance ◽  
Carbonaceous Material ◽  
Contamination Rate ◽  
Low Molecular Weight ◽  
Principal Source ◽  
Rotary Pumps ◽  
Electron Microscopes

The earliest account of the contamination of electron microscope specimens by the deposition of carbonaceous material during electron irradiation was published in 1947 by Watson who was then working in Canada. It was soon established that this carbonaceous material is formed from organic vapours, and it is now recognized that the principal source is the oil-sealed rotary pumps which provide the backing vacuum. It has been shown that the organic vapours consist of low molecular weight fragments of oil molecules which have been degraded at hot spots produced by friction between the vanes and the surfaces on which they slide. As satisfactory oil-free pumps are unavailable, it is standard electron microscope practice to reduce the partial pressure of organic vapours in the microscope in the vicinity of the specimen by using liquid-nitrogen cooled anti-contamination devices. Traps of this type are sufficient to reduce the contamination rate to about 0.1 Å per min, which is tolerable for many investigations.

Low-molecular-weight heparin in the prevention and treatment of thromboembolic disorders

1998 ◽  
Vol 1 (5) ◽  
pp. 166-174 ◽  
Author(s):  
Evelyn R Hermes De Santis ◽  
Betsy S Laumeister ◽  
Vidhu Bansal ◽  
Vandana Kataria ◽  
Preeti Loomba ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Prevention And Treatment
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