ChemInform Abstract: Two Approaches to Automated Solid Phase Synthesis of Small Organic Compound Arrays

ChemInform ◽  
2000 ◽  
Vol 31 (42) ◽  
pp. no-no
Author(s):  
Michal Lebl ◽  
Viktor Krchnak ◽  
Georges Ibrahim ◽  
Jaylynn Pirez ◽  
Yidong Ni ◽  
...  
Keyword(s):  
Organic Compound ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Compound Arrays

Two Approaches to Automated Solid Phase Synthesis of Small Organic Compound Arrays

1999 ◽  
pp. 91-96
Author(s):  
Michal Lebl ◽  
Viktor Krchňák ◽  
Georges Ibrahim ◽  
Jaylynn Pirez ◽  
Yidong Ni ◽  
...  
Keyword(s):  
Organic Compound ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Compound Arrays

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

Sign in / Sign up

Export Citation Format

Share Document