ChemInform Abstract: Stereoselective Synthesis of all-trans Methyl Substituted Polyenes by Reductive Elimination and Application to the Synthesis of all-trans 3-Methyl-nona-2,4,6-trienol.

ChemInform ◽  
2000 ◽  
Vol 31 (37) ◽  
pp. no-no
Author(s):  
Guy Solladie ◽  
Francoise Colobert ◽  
Chakib Kalai
Keyword(s):  
Stereoselective Synthesis ◽  
Reductive Elimination ◽  
Trans Methyl ◽  
Substituted Polyenes

scholarly journals Palladium-catalyzed regio- and stereoselective synthesis of aryl and 3-indolyl-substituted 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones

2020 ◽  
Vol 16 ◽  
pp. 1084-1091 ◽  
Author(s):  
Valeria Nori ◽  
Antonio Arcadi ◽  
Armando Carlone ◽  
Fabio Marinelli ◽  
Marco Chiarini
Keyword(s):  
Stereoselective Synthesis ◽  
Reductive Elimination ◽  
Aryl Iodide ◽  
Arylboronic Acids ◽  
Palladium Catalyzed

Cascade cyclocarbopalladation of the readily available aryl/alkyl-substituted propargylic amides containing an aryl iodide moiety, followed by Suzuki–Miyaura coupling with arylboronic acids, allowed an efficient regio- and stereoselective synthesis of tetrasubstituted 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones. Moreover, cascade cyclocarbopalladation, followed by the reaction with 2-alkynyltrifluoroacetanilides, accomplished a double cyclization to afford challenging 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones bearing a 3-indolyl substituent through aminopalladation/reductive elimination.

scholarly journals Palladium-Catalyzed Regio- and Stereoselective Synthesis of Aryl and 3-Indolyl Substituted-4-Methylene- isoquinolin-1(2H)-ones.

2020 ◽  
Author(s):  
Valeria Nori ◽  
Antonio Arcadi ◽  
Armando Carlone ◽  
Fabio Marinelli ◽  
Marco Chiarini
Keyword(s):  
Stereoselective Synthesis ◽  
Reductive Elimination ◽  
Aryl Iodide ◽  
Arylboronic Acids ◽  
Palladium Catalyzed

Cascade cyclocarbopalladation of the readily available aryl/alkyl-substituted propargylic amides containing an aryl iodide moiety, followed by Suzuki-Miyaura coupling with arylboronic acids, allowed an efficient regio- and stereoselective synthesis of tetrasubstituted-4-methylene-isoquinolin-1(2H)-ones. Moreover cascade cyclocarbopalladation, followed by reaction with 2- alkynyltrifluoroacetanilides, accomplished a double cyclization, to afford challenging 4-methylene-isoquinolin-1(2H)-ones bearing a 3-indolyl substituent, through aminopalladation/reductive elimination

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