ChemInform Abstract: Suppressed β-Hydride Elimination in Palladium-Catalyzed Cascade Cyclization-Coupling Reactions: An Efficient Synthesis of 3-Arylmethylpyrrolidines.

ChemInform ◽  
2010 ◽  
Vol 31 (34) ◽  
pp. no-no
Author(s):  
Chi-Wan Lee ◽  
Kyung Seok Oh ◽  
Kwang S. Kim ◽  
Kyo Han Ahn
Keyword(s):  
Coupling Reactions ◽  
Efficient Synthesis ◽  
Cascade Cyclization ◽  
Palladium Catalyzed ◽  
Hydride Elimination

scholarly journals Palladium(II)-Catalyzed Efficient Synthesis of Wedelolactone and Evaluation as Potential Tyrosinase Inhibitor

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4130
Author(s):  
Huidan Huang ◽  
Jianqiu Chen ◽  
Jie Ren ◽  
Chaofeng Zhang ◽  
Fei Ji
Keyword(s):  
Natural Product ◽  
Raw Material ◽  
Coupling Reactions ◽  
Biosynthesis Pathway ◽  
Tyrosinase Inhibitor ◽  
Efficient Synthesis ◽  
Melanin Biosynthesis ◽  
Methodological Research ◽  
Palladium Catalyzed ◽  
Tyrosinase Inhibitors

Tyrosinase is an enzyme widely distributed in nature, which has multiple functions, especially in the melanin biosynthesis pathway. Despite the few clinically available tyrosinase inhibitors for whitening, a great demand remains for novel compounds with low side effects in terms of potential carcinogenicity and improved clinical efficacy. A natural product, wedelolactone (WEL), with a polyhydroxyl moiety, attracted our attention as a potential tyrosinase inhibitor. Before we studied the biological activity of the natural product, a synthetic methodological research was firstly carried to obtain enough raw material. WEL could be obtained efficiently through palladium-catalyzed boronation/coupling reactions and 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ)-involved oxidative deprotection/annulation reactions. Immediately after, the natural product was proven to be an efficient tyrosinase inhibitor. In conclusion, we developed a mild and efficient approach for the preparation of WEL, and the natural product was disclosed to have anti-tyrosinase activity, which could be widely used in multiple fields.

Efficient synthesis of 2-phenyl-3-substituted furo/thieno[2,3-b]quinoxalines via Sonogashira coupling reaction followed by iodocyclization and subsequent palladium-catalyzed cross-coupling reactions

RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 83901-83908 ◽  
Author(s):  
Tayebeh Besharati-Seidani ◽  
Ali Keivanloo ◽  
Babak Kaboudin ◽  
Tsutomu Yokomatsu
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Sonogashira Coupling ◽  
Efficient Synthesis ◽  
Cross Coupling Reactions ◽  
Sonogashira Coupling Reaction ◽  
Quinoxaline Derivatives ◽  
Palladium Catalyzed

In this paper, we report the successful synthesis of new 2-phenyl-3-substituted furo/thieno[2,3-b]quinoxaline derivatives from 2-chloro-3-methoxyquinoxaline and 2-chloro-3-(methylthio)quinoxaline by a three-step approach.

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