The elimination of volatile organic solvents in organic synthesis is the most important goal
in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl
bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which
could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The
procedure has advantages such as short reaction time, operationally simple, excellent product yields,
high regioselectivity and organic solvent-free.
One-pot Preparation of ?–amino Carbonyl Compounds by Mannich Reaction Using MgO/ZrO2 as Effective and Reusable Catalyst