ChemInform Abstract: Studies on the Nonmevalonate Pathway: Formation of 2-C-Methyl-D-erythritol 2,4-Cyclodiphosphate from 2-Phospho-4-(cytidine 5′-Diphospho)-2-C-methyl-D-erythritol.

ChemInform ◽  
2010 ◽  
Vol 31 (32) ◽  
pp. no-no
Author(s):  
Motoki Takagi ◽  
Tomohisa Kuzuyama ◽  
Kazuhide Kaneda ◽  
Hiroyuki Watanabe ◽  
Tohru Dairi ◽  
...  
Keyword(s):  
Nonmevalonate Pathway ◽  
Pathway Formation

Studies on the nonmevalonate pathway: formation of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol

2000 ◽  
Vol 41 (18) ◽  
pp. 3395-3398 ◽  
Author(s):  
Motoki Takagi ◽  
Tomohisa Kuzuyama† ◽  
Kazuhide Kaneda ◽  
Hiroyuki Watanabe ◽  
Tohru Dairi ◽  
...  
Keyword(s):  
Nonmevalonate Pathway ◽  
Pathway Formation

scholarly journals The lytB Gene of Escherichia coli Is Essential and Specifies a Product Needed for Isoprenoid Biosynthesis

2001 ◽  
Vol 183 (24) ◽  
pp. 7403-7407 ◽  
Author(s):  
Sean McAteer ◽  
Andrew Coulson ◽  
Neil McLennan ◽  
Millicent Masters
Keyword(s):  
Escherichia Coli ◽  
Protein Structure ◽  
Cell Lysis ◽  
Isoprenoid Biosynthesis ◽  
Globular Protein ◽  
Limited Growth ◽  
E Coli ◽  
Nonmevalonate Pathway ◽  
Tim Barrel

ABSTRACT LytB and GcpE, because they are codistributed with other pathway enzymes, have been predicted to catalyze unknown steps in the nonmevalonate pathway for isoprenoid biosynthesis. We constructed a conditional Escherichia coli lytB mutant and found that LytB is essential for survival and that depletion of LytB results in cell lysis, which is consistent with a role for this protein in isoprenoid biosynthesis. Alcohols which can be converted to pathway intermediates beyond the hypothesized LytB step(s) support limited growth of E. coli lytB mutants. An informatic analysis of protein structure suggested that GcpE is a globular protein of the TIM barrel class and that LytB is also a globular protein. Possible biochemical roles for LytB and GcpE are suggested.

scholarly journals Physiological requirements of the nonmevalonate pathway for photo-acclimation in Arabidopsis

2005 ◽  
Vol 22 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Masaya Hojo ◽  
Masao Tasaka ◽  
Toshiharu Shikanai
Keyword(s):  
Nonmevalonate Pathway

Chemical Basis of Nitrogen Recovery through the Ureide Pathway: Formation and Hydrolysis ofS-Ureidoglycine in Plants and Bacteria

2010 ◽  
Vol 5 (2) ◽  
pp. 203-214 ◽  
Author(s):  
Fabio Serventi ◽  
Ileana Ramazzina ◽  
Ilaria Lamberto ◽  
Vincenzo Puggioni ◽  
Rita Gatti ◽  
...  
Keyword(s):  
Nitrogen Recovery ◽  
Chemical Basis ◽  
Pathway Formation

scholarly journals Malformations of Cerebral Cortex Development: Molecules and Mechanisms

2019 ◽  
Vol 14 (1) ◽  
pp. 293-318 ◽  
Author(s):  
Gordana Juric-Sekhar ◽  
Robert F. Hevner
Keyword(s):  
Genetic Basis ◽  
Focal Cortical Dysplasia ◽  
Mammalian Target Of Rapamycin ◽  
Sequencing Technologies ◽  
Brain Anomalies ◽  
Brain Malformations ◽  
Pathway Formation ◽  
Molecular Bases ◽  
Cortical Progenitor ◽  
Neuroimaging Techniques

Malformations of cortical development encompass heterogeneous groups of structural brain anomalies associated with complex neurodevelopmental disorders and diverse genetic and nongenetic etiologies. Recent progress in understanding the genetic basis of brain malformations has been driven by extraordinary advances in DNA sequencing technologies. For example, somatic mosaic mutations that activate mammalian target of rapamycin signaling in cortical progenitor cells during development are now recognized as the cause of hemimegalencephaly and some types of focal cortical dysplasia. In addition, research on brain development has begun to reveal the cellular and molecular bases of cortical gyrification and axon pathway formation, providing better understanding of disorders involving these processes. New neuroimaging techniques with improved resolution have enhanced our ability to characterize subtle malformations, such as those associated with intellectual disability and autism. In this review, we broadly discuss cortical malformations and focus on several for which genetic etiologies have elucidated pathogenesis.

Development and pathway formation of peripheral neurons during leech embryogenesis

1998 ◽  
Vol 397 (3) ◽  
pp. 394-402 ◽  
Author(s):  
Yueqiao Huang ◽  
John Jellies ◽  
Kristen M. Johansen ◽  
J�rgen Johansen
Keyword(s):  
Peripheral Neurons ◽  
Pathway Formation
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