ChemInform Abstract: Conjugate Additions of 1-Propenylphosphonates to Metalated Schoellkopf′s Bis-lactim Ether: Stereocontrolled Access to 2-Amino-3-methyl-4-phosphonobutanoic Acids.

ChemInform ◽  
2010 ◽  
Vol 31 (29) ◽  
pp. no-no
Author(s):  
Vicente Ojea ◽  
Maria Ruiz ◽  
Gideon Shapiro ◽  
Esteban Pombo-Villar
Keyword(s):  
Conjugate Additions ◽  
Lactim Ether

Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules

2016 ◽  
Vol 21 (3) ◽  
pp. 190-217 ◽  
Author(s):  
Paola Vitale ◽  
Vito Capriati ◽  
Saverio Florio ◽  
Filippo Perna ◽  
Antonio Salomone
Keyword(s):  
Conjugate Additions ◽  
Complex Molecules

Synthetic Strategies to Access Heteroatomic Spirocentres Embedded in Natural Products

Synthesis ◽  
2021 ◽  
Author(s):  
Michael P. Badart ◽  
Bill C. Hawkins
Keyword(s):  
Natural Products ◽  
Heterocyclic Compound ◽  
Chemical Space ◽  
Three Dimensional ◽  
Coupling Reactions ◽  
Conjugate Additions ◽  
Biological Targets ◽  
Compound Libraries ◽  
The Common ◽  
Significant Attention

AbstractThe spirocyclic motif is abundant in natural products and provides an ideal three-dimensional template to interact with biological targets. With significant attention historically expended on the synthesis of flat-heterocyclic compound libraries, methods to access the less-explored three-dimensional medicinal-chemical space will continue to increase in demand. Herein, we highlight by reaction class the common strategies used to construct the spirocyclic centres embedded in a series of well-studied natural products.1 Introduction2 Cycloadditions3 Palladium-Catalysed Coupling Reactions4 Conjugate Additions5 Imines, Aminals, and Hemiaminal Ethers6 Mannich-Type Reactions7 Oxidative Dearomatisation8 Alkylation9 Organometallic Additions10 Conclusions

scholarly journals Catalytic Conjugate Additions of Carbonyl Anions under Neutral Aqueous Conditions.

ChemInform ◽  
2006 ◽  
Vol 37 (9) ◽  
Author(s):  
Michael C. Myers ◽  
Ashwin R. Bharadwaj ◽  
Benjamin C. Milgram ◽  
Karl A. Scheidt
Keyword(s):  
Conjugate Additions ◽  
Aqueous Conditions

Conjugate Additions of Secondary Amines and Water to Allenyl Perfluoroalkyl Sulfones

2006 ◽  
Vol 24 (6) ◽  
pp. 775-780 ◽  
Author(s):  
Xiao-Jin Wang ◽  
Yun Lin ◽  
Jin-Tao Liu
Keyword(s):  
Secondary Amines ◽  
Conjugate Additions

Conjugate Additions to Vinyl-Substituted Aromatic N-Heterocycles

Synlett ◽  
2012 ◽  
Vol 23 (11) ◽  
pp. 1590-1604 ◽  
Author(s):  
Douglas Klumpp
Keyword(s):  
Conjugate Additions

New synthesis of pyrido[4,3-b]indoles (γ-carbolines) on the basis of indolin-2-one lactim ether

2008 ◽  
Vol 57 (1) ◽  
pp. 177-185 ◽  
Author(s):  
T. V. Golovko ◽  
N. P. Solov’eva ◽  
O. S. Anisimova ◽  
O. B. Smirnova ◽  
M. I. Evstratova ◽  
...  
Keyword(s):  
New Synthesis ◽  
Lactim Ether
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