ChemInform Abstract: Acridone Alkaloids from the Root Bark of Severinia buxifolia in Hainan.

ChemInform ◽  
2010 ◽  
Vol 31 (26) ◽  
pp. no-no
Author(s):  
Tian-Shung Wu ◽  
Chien-Mao Chen
Keyword(s):  
Root Bark ◽  
Acridone Alkaloids ◽  
Severinia Buxifolia

Acridone alkaloids from Severinia buxifolia

1982 ◽  
Vol 21 (7) ◽  
pp. 1771-1773 ◽  
Author(s):  
Wu Tian-Shung ◽  
Kuoh Cheng-Sheng ◽  
Hiroshi Furukawa
Keyword(s):  
Acridone Alkaloids ◽  
Severinia Buxifolia

scholarly journals Severibuxine, Isolated from Severinia buxifolia, Induces Apoptosis in HL-60 Leukemia Cells

2013 ◽  
Vol 8 (6) ◽  
pp. 1934578X1300800
Author(s):  
Chihiro Ito ◽  
Tomiyasu Murata ◽  
Midori Kato ◽  
Natsu Suzuki ◽  
Tian-Shung Wu ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Microscopic Analysis ◽  
Time Dependent ◽  
Root Bark ◽  
Dependent Manner ◽  
Caspase 9 ◽  
Nuclear Condensation ◽  
Apoptotic Effect ◽  
Induced Apoptosis ◽  
Severinia Buxifolia

In an ongoing search for cancer-preventing compounds derived from plant sources, we isolated the quinolin-2,4-dione alkaloid severibuxine from the root bark of Severinia buxifolia collected in Taiwan and then examined the apoptotic effect of this compound. Severibuxine showed cytotoxicity to leukemia HL-60 cells (IC50 = 12.3±0.6 μM). Fluorescence microscopic analysis of cells stained with Hoechst 33342 indicated that the percentage of apoptotic cells showing nuclear condensation and fragmentation increased in a time-dependent manner. In addition, the activities of caspase-9 and caspase-3 were also enhanced in a time-dependent manner upon treatment with severibuxine. The addition of caspase-9 and caspase-3 inhibitors blocked severibuxine-mediated apoptosis. Upon treatment with severibuxine, the mitochondrial membrane potential decreased in a time-dependent manner. Severibuxine induced apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, which is triggered by mitochondrial dysfunction.

Isolation of cytotoxic polyphenolic derivatives from the root bark of Mesua ferrea

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
SS Teh ◽  
GCL Ee ◽  
YM Lim
Keyword(s):  
Root Bark

Constituents from Morus root bark against Venturia inaequalis – the causal agent of apple scab

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
JM Rollinger ◽  
R Spitaler ◽  
M Menz ◽  
P Schneider ◽  
EP Ellmerer ◽  
...  
Keyword(s):  
Venturia Inaequalis ◽  
Apple Scab ◽  
Causal Agent ◽  
Root Bark

Antidepressant Activity of Ethanol Extract and Residual Aqueous Fraction of Carissa edulis (Apocynaceae) Root Bark in Mice

2017 ◽  
Vol 1 (3) ◽  
pp. 129-132
Author(s):  
Jamilu Ya’u ◽  
◽  
Sani Malami ◽  
Mohammed Abugi ◽  
Hyelnaya Ngura ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Antidepressant Activity ◽  
Root Bark ◽  
Aqueous Fraction

Arjunolic Acid from the Root Bark of Terminalia catappa Linn

2018 ◽  
Vol 2 (11) ◽  
pp. 494-497
Author(s):  
Nahandoo Ichôron ◽  
Terrumun Tor-Anyiin ◽  
John Igoli
Keyword(s):  
Root Bark ◽  
Terminalia Catappa ◽  
Arjunolic Acid

Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats

1970 ◽  
Vol 1 (3) ◽  
pp. 281-286
Author(s):  
Pradeep Deshmukh ◽  
Tanaji Nandgude ◽  
Mahendra Singh Rathode ◽  
Anil Midha ◽  
Nitin Jaiswal
Keyword(s):  
Methyl Cellulose ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Root Bark ◽  
Significant Activity ◽  
Alcoholic Extract ◽  
Calotropis Gigantea ◽  
Wistar Albino Rats ◽  
Experimental Liver ◽  
Hepatoprotective Drug

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).

Effect of Morus alba Root Bark, Ecklonia stolonifera, and Curcuma aromatica Extracts on Shelf-life and Quality of Castella

2009 ◽  
Vol 38 (10) ◽  
pp. 1444-1451 ◽  
Author(s):  
So-Young Yoon ◽  
Jung-Soo Choi ◽  
So-Young Lee ◽  
Koth-Bong-Woo-Ri Kim ◽  
Eu-Jin Song ◽  
...  
Keyword(s):  
Shelf Life ◽  
Morus Alba ◽  
Root Bark ◽  
Ecklonia Stolonifera
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