ChemInform Abstract: Synthetic Studies Toward Dideoxynojirimycin Derivatives via Dehydroamino Acid as a Key Intermediate.

ChemInform ◽  
2010 ◽  
Vol 31 (21) ◽  
pp. no-no
Author(s):  
Jeeah Choi ◽  
Jeong E. Nam Shin ◽  
Keun Ho Chun
Keyword(s):  
Synthetic Studies ◽  
Dehydroamino Acid

Synthetic studies on thiostrepton family of peptide antibiotics: synthesis of the pentapeptide segment containing dihydroxyisoleucine, thiazoline and dehydroamino acid

2004 ◽  
Vol 45 (19) ◽  
pp. 3707-3712 ◽  
Author(s):  
Shuhei Higashibayashi ◽  
Mitsunori Kohno ◽  
Taiji Goto ◽  
Kengo Suzuki ◽  
Tomonori Mori ◽  
...  
Keyword(s):  
Peptide Antibiotics ◽  
Synthetic Studies ◽  
Dehydroamino Acid

Synthetic Studies on Thiostrepton Family of Peptide Antibiotics: Synthesis of the Pentapeptide Segment Containing Dihydroxyisoleucine, Thiazoline and Dehydroamino Acid.

ChemInform ◽  
2004 ◽  
Vol 35 (33) ◽  
Author(s):  
Shuhei Higashibayashi ◽  
Mitsunori Kohno ◽  
Taiji Goto ◽  
Kengo Suzuki ◽  
Tomonori Mori ◽  
...  
Keyword(s):  
Peptide Antibiotics ◽  
Synthetic Studies ◽  
Dehydroamino Acid

Synthetic studies toward inducamide C

2021 ◽  
Author(s):  
Ardalan A. Nabi ◽  
Lydia M. Scott ◽  
Daniel P. Furkert ◽  
Jonathan Sperry
Keyword(s):  
Natural Product ◽  
Structural Revision ◽  
Synthetic Studies

The rare benzoxazepine ring in the alkaloid inducamide C is unstable and prone to rearrangement, indicating that structural revision of the natural product may be necessary.

scholarly journals Tackling Pristinamycin IIB Problems: Synthetic Studies toward Some Fluorinated Analogs

2020 ◽  
Vol 3 (1) ◽  
pp. 107
Author(s):  
Assia Chebieb ◽  
Chewki Ziani-Cherif
Keyword(s):  
Chemical Structure ◽  
Wittig Reaction ◽  
Antimicrobial Agents ◽  
Synthetic Approach ◽  
Solubility In Water ◽  
Fluorinated Analogs ◽  
Human Therapy ◽  
Primary Structures ◽  
Synthetic Studies

Streptogramins are potent antibiotics against numerous highly resistant pathogens and therefore are used in last-resort human therapy. These antibiotics are formed of both A- and B-group compounds named pristinamycins that differ in their basic primary structures. Although pristinamycin IIB is among the most interesting antibiotics in this family, it presents numerous problems related to its chemical structure, such as instability at most pH levels, weak solubility in water, and resistance by bacteria. As a response to the need for developing new antimicrobial agents, we have designed a new analog of pristinamycin IIB, based most importantly on the introduction of fluorine atoms. We conjectured indeed that the introduced modifications may solve the above-mentioned problems exhibited by pristinamycin IIB. Our multistep synthetic approach relies on few key reactions, namely a Wittig reaction, a Grubbs reaction, and dihydroxy, -difluoro API (Advanced Pharmaceutical Intermediate) synthesis

Sign in / Sign up

Export Citation Format

Share Document