ChemInform Abstract: Phorbols: Chemical Synthesis and Chemical Biology

Masakatsu Shibasaki

doi:10.1002/chin.200019276

RNA Chemistry for RNA Biology

CHIMIA International Journal for Chemistry ◽

10.2533/chimia.2019.368 ◽

2019 ◽

Vol 73 (5) ◽

pp. 368-373 ◽

Cited By ~ 2

Author(s):

Pascal Röthlisberger ◽

Christian Berk ◽

Jonathan Hall

Keyword(s):

Chemical Synthesis ◽

Nucleic Acids ◽

Chemical Biology ◽

Rna Synthesis ◽

Intrinsic Properties ◽

Chemical Modifications ◽

Chemically Modified ◽

Wide Range ◽

Rna Biology ◽

Modified Nucleic Acids

Advances in the chemical synthesis of RNA have opened new possibilities to address current questions in RNA biology. Access to site-specifically modified oligoribonucleotides is often a pre-requisite for RNA chemical-biology projects. Driven by the enormous research efforts for development of oligonucleotide therapeutics, a wide range of chemical modifications have been developed to modulate the intrinsic properties of nucleic acids in order to fit their use as therapeutics or research tools. The RNA synthesis platform, supported by the NCCR RNA & Disease, aims to provide access to a large variety of chemically modified nucleic acids. In this review, we describe some of the recent projects that involved work of the platform and highlight how RNA chemistry supports new discoveries in RNA biology.

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Adventures in Carbohydrate Chemistry: New Synthetic Technologies, Chemical Synthesis, Molecular Design, and Chemical Biology

Angewandte Chemie International Edition ◽

10.1002/1521-3773(20010504)40:9<1576::aid-anie15760>3.0.co;2-g ◽

2001 ◽

Vol 40 (9) ◽

pp. 1576-1624 ◽

Cited By ~ 279

Author(s):

K. C. Nicolaou ◽

Helen J. Mitchell

Keyword(s):

Chemical Synthesis ◽

Chemical Biology ◽

Molecular Design ◽

Carbohydrate Chemistry

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Peptides for Infectious Diseases: From Probe Design to Diagnostic Microarrays

Antibodies ◽

10.3390/antib8010023 ◽

2019 ◽

Vol 8 (1) ◽

pp. 23 ◽

Cited By ~ 8

Author(s):

Marina Cretich ◽

Alessandro Gori ◽

Ilda D’Annessa ◽

Marcella Chiari ◽

Giorgio Colombo

Keyword(s):

Infectious Diseases ◽

Chemical Synthesis ◽

Chemical Biology ◽

Viral Infections ◽

Computational Prediction ◽

Probe Design ◽

Protein Antigens ◽

Integrated Strategy ◽

Synthetic Accessibility ◽

Diagnostic Applications

Peptides and peptidomimetics have attracted revived interest regarding their applications in chemical biology over the last few years. Their chemical versatility, synthetic accessibility and the ease of storage and management compared to full proteins have made peptides particularly interesting in diagnostic applications, where they proved to efficiently recapitulate the molecular recognition properties of larger protein antigens, and were proven to be able to capture antibodies circulating in the plasma and serum of patients previously exposed to bacterial or viral infections. Here, we describe the development, integration and application of strategies for computational prediction and design, advanced chemical synthesis, and diagnostic deployment in multiplexed assays of peptide-based materials which are able to bind antibodies of diagnostic as well as therapeutic interest. By presenting successful applications of such an integrated strategy, we argue that they will have an ever-increasing role in both basic and clinical realms of research, where important advances can be expected in the next few years.

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