ChemInform Abstract: Synthesis of δ-Amino Acids with an Ether Linkage in the Main Chain and Nucleobases on the Side Chain as Monomer Units for Oxy-Peptide Nucleic Acids.

ChemInform ◽  
2010 ◽  
Vol 30 (51) ◽  
pp. no-no ◽  
Author(s):  
Masayasu Kuwahara ◽  
Miki Arimitsu ◽  
Masahiko Sisido
Keyword(s):  
Amino Acids ◽  
Nucleic Acids ◽  
Main Chain ◽  
Peptide Nucleic Acids ◽  
Side Chain ◽  
Ether Linkage

Destabilization of the 310-Helix in Peptides Based on Cα-Tetrasubstituted α-Amino Acids by Main-Chain to Side-Chain Hydrogen Bonds

1998 ◽  
Vol 120 (45) ◽  
pp. 11558-11566 ◽  
Author(s):  
Wojciech M. Wolf ◽  
Marcin Stasiak ◽  
Miroslav T. Leplawy ◽  
Alberto Bianco ◽  
Fernando Formaggio ◽  
...  
Keyword(s):  
Amino Acids ◽  
Hydrogen Bonds ◽  
Main Chain ◽  
Side Chain ◽  
310 Helix

Side chain homologation of alanyl peptide nucleic acids: pairing selectivity and stacking

2005 ◽  
Vol 3 (6) ◽  
pp. 1058 ◽  
Author(s):  
Ulf Diederichsen ◽  
Daniel Weicherding ◽  
Nicola Diezemann
Keyword(s):  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Side Chain

scholarly journals Anti-cancer peptides: classification, mechanism of action, reconstruction and modification

Open Biology ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 200004
Author(s):  
Mingfeng Xie ◽  
Dijia Liu ◽  
Yufeng Yang
Keyword(s):  
Amino Acids ◽  
Cell Proliferation ◽  
Drug Resistance ◽  
Mechanism Of Action ◽  
Main Chain ◽  
Side Chain ◽  
Short Peptides ◽  
Anti Cancer ◽  
Cancer Activity ◽  
Tumour Blood

Anti-cancer peptides (ACPs) are a series of short peptides composed of 10–60 amino acids that can inhibit tumour cell proliferation or migration, or suppress the formation of tumour blood vessels, and are less likely to cause drug resistance. The aforementioned merits make ACPs the most promising anti-cancer candidate. However, ACPs may be degraded by proteases, or result in cytotoxicity in many cases. To overcome these drawbacks, a plethora of research has focused on reconstruction or modification of ACPs to improve their anti-cancer activity, while reducing their cytotoxicity. The modification of ACPs mainly includes main chain reconstruction and side chain modification. After summarizing the classification and mechanism of action of ACPs, this paper focuses on recent development and progress about their reconstruction and modification. The information collected here may provide some ideas for further research on ACPs, in particular their modification.

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