ChemInform Abstract: Reactions of Cyclic Anhydrides with Aromatic Primary Amines. Part 3. Synthesis of Novel 3-(N-Arylcarbamoyl)- and 3-(N-Naphthylcarbamoyl)carboxylic Acids.

ChemInform ◽  
2010 ◽  
Vol 30 (8) ◽  
pp. no-no
Author(s):  
V. O. T. Omuaru
Keyword(s):  
Carboxylic Acids ◽  
Primary Amines ◽  
Cyclic Anhydrides

Biological Activity of Novel N-Substituted Amides of endo-3- (3-Methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene-2- carboxylic Acid and N-Substituted Amides of 1-(5-Methylthio- 1,2,4-triazol-3-yl)cyclohexane-2-carboxylic Acids

2012 ◽  
Vol 67 (3-4) ◽  
pp. 123-128
Author(s):  
Anna Pachuta-Stec ◽  
Urszula Kosikowska ◽  
Anna Chodkowska ◽  
Monika Pitucha ◽  
Anna Malm ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Condensation Reaction ◽  
Primary Amines ◽  
Pharmacological Activities

N-Substituted amides of endo-3-(3-methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene- 2-carboxylic acid and 1-(5-methylthio-1,2,4-triazol-3-yl)cyclohexane-2-carboxylic acid were prepared by the condensation reaction of endo-S-methyl-N1-(bicyclo[2.2.1]hept-5-ene-2,3- dicarbonyl)isothiosemicarbazide and S-methyl-N1-(cyclohexane-2,3-dicarbonyl)isothiosemicarbazide with primary amines. The synthesized compounds were screened for their microbiological and pharmacological activities

scholarly journals Manganese-mediated reductive functionalization of activated aliphatic acids and primary amines

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhan Li ◽  
Ke-Feng Wang ◽  
Xin Zhao ◽  
Huihui Ti ◽  
Xu-Ge Liu ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Late Stage ◽  
Materials Science ◽  
Reaction Pathway ◽  
Chemical Conversion ◽  
Primary Amines ◽  
Mechanistic Studies ◽  
Reaction Conditions ◽  
Aliphatic Acids ◽  
Redox Active

Abstract Alkyl carboxylic acids as well as primary amines are ubiquitous in all facets of biological science, pharmaceutical science, chemical science and materials science. By chemical conversion to redox-active esters (RAE) and Katritzky’s N-alkylpyridinium salts, respectively, alkyl carboxylic acids and primary amines serve as ideal starting materials to forge new connections. In this work, a Mn-mediated reductive decarboxylative/deaminative functionalization of activated aliphatic acids and primary amines is disclosed. A series of C-X (X = S, Se, Te, H, P) and C-C bonds are efficiently constructed under simple and mild reaction conditions. The protocol is applicable to the late-stage modification of some structurally complex natural products or drugs. Preliminary mechanistic studies suggest the involvement of radicals in the reaction pathway.

Substrate selective amide coupling driven by encapsulation of a coupling agent within a self-assembled hexameric capsule

2015 ◽  
Vol 51 (9) ◽  
pp. 1658-1661 ◽  
Author(s):  
Sonia Giust ◽  
Giorgio La Sorella ◽  
Laura Sperni ◽  
Giorgio Strukul ◽  
Alessandro Scarso
Keyword(s):  
Carboxylic Acids ◽  
Coupling Agent ◽  
Primary Amines ◽  
Substrate Selectivity ◽  
Synthesis Reaction ◽  
Amide Synthesis ◽  
Amide Coupling ◽  
Self Assembled

Encapsulation of a cationic carbodiimide condensing agent within a self-assembled hexameric capsule made of resorcin[4]arene units provides a nano-environment that efficiently steers the substrate selectivity in the amide synthesis reaction between carboxylic acids and primary amines.

scholarly journals Radical-mediated dehydrative preparation of cyclic imides using (NH4)2S2O8–DMSO: application to the synthesis of vernakalant

2015 ◽  
Vol 11 ◽  
pp. 1008-1016 ◽  
Author(s):  
Dnyaneshwar N Garad ◽  
Subhash D Tanpure ◽  
Santosh B Mhaske
Keyword(s):  
Dimethyl Sulfoxide ◽  
Ammonium Persulfate ◽  
Primary Amines ◽  
Radical Mechanism ◽  
Forming Process ◽  
One Pot ◽  
Practical Synthesis ◽  
Cyclic Imides ◽  
Cyclic Anhydrides ◽  
High Yields

Ammonium persulfate–dimethyl sulfoxide (APS–DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.

Studies on transition-metal nitrido and oxo complexes. Part 20. Oxoruthenates and oxo-osmates in oxidation catalysis; cis-[Os(OH)2O4]2- as a catalytic oxidant for primary amines and for alcohols

2001 ◽  
Vol 79 (5-6) ◽  
pp. 598-606 ◽  
Author(s):  
William P Griffith ◽  
Maria Suriaatmaja
Keyword(s):  
Raman Spectroscopy ◽  
Transition Metal ◽  
Carboxylic Acids ◽  
Oxidative Dehydrogenation ◽  
Alcohol Oxidation ◽  
Oxidation Catalysis ◽  
Primary Amines ◽  
Secondary Alcohols ◽  
Primary Alcohols ◽  
Aromatic And Aliphatic Amines

cis-[Os(OH)2O4]2– with [Fe(CN)6]3– and other co-oxidants has been studied as a catalytic reagent for the oxidative dehydrogenation of primary aromatic and aliphatic amines to nitriles, the oxidation of primary alcohols to carboxylic acids and of secondary alcohols to ketones. Electronic and Raman spectroscopy have been used to elucidate the nature of the oxoruthenates and oxo-osmates present in a number of reported organic oxidations catalyzed by ruthenium and osmium species.Key words: oxidation catalysis, ruthenium, osmium, amine dehydrogenation, alcohol oxidation.

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