ChemInform Abstract: Tandem Radical Cyclizations Leading to Indolizidinones and Pyrrolizidinones.

ChemInform ◽  
2010 ◽  
Vol 29 (50) ◽  
pp. no-no
Author(s):  
S. R. BAKER ◽  
A. F. PARSONS ◽  
J.-F. PONS ◽  
M. WILSON
Keyword(s):  
Radical Cyclizations

scholarly journals Activation modes in biocatalytic radical cyclization reactions

2021 ◽  
Author(s):  
Yuxuan Ye ◽  
Haigen Fu ◽  
Todd K Hyster
Keyword(s):  
Heme Iron ◽  
Radical Cyclization ◽  
Cytochrome P450 Monooxygenases ◽  
Radical Cyclizations ◽  
Cyclization Reactions ◽  
Complex Molecules ◽  
P450 Monooxygenases ◽  
Non Heme Iron ◽  
Essential Reactions ◽  
Isopenicillin N

Abstract Radical cyclizations are essential reactions in the biosynthesis of secondary metabolites and the chemical synthesis of societally valuable molecules. In this review, we highlight the general mechanisms utilized in biocatalytic radical cyclizations. We specifically highlight cytochrome P450 monooxygenases (P450s) involved in the biosynthesis of mycocyclosin and vancomycin, non-heme iron- and α-ketoglutarate-dependent dioxygenases (Fe/αKGDs) used in the biosynthesis of kainic acid, scopolamine, and isopenicillin N, and radical S-adenosylmethionine (SAM) enzymes that facilitate the biosynthesis of oxetanocin A, menaquinone, and F420. Beyond natural mechanisms, we also examine repurposed flavin-dependent ‘ene’-reductases (ERED) for non-natural radical cyclization. Overall, these general mechanisms underscore the opportunity for enzymes to augment and enhance the synthesis of complex molecules using radical mechanisms.

The Study of Intramolecular Tandem Radical Cyclizations of Acylsilanes with Radicalphiles Attached on Silicon.

ChemInform ◽  
2005 ◽  
Vol 36 (26) ◽  
Author(s):  
Kuo-Hsiang Tang ◽  
Fang-Yu Liao ◽  
Yeun-Min Tsai
Keyword(s):  
Radical Cyclizations

Synthesis of 3,3-disubstituted oxindoles by organoselenium-induced radical cyclizations of N-arylacrylamides

2015 ◽  
Vol 21 (1) ◽  
Author(s):  
Wei-jun Fu ◽  
Mei Zhu ◽  
Guang-long Zou
Keyword(s):  
Practical Approach ◽  
Radical Cyclizations

AbstractA simple and practical approach to oxindole derivatives

ChemInform Abstract: The Application of Intramolecular Radical Cyclizations of Acylsilanes in the Regiospecific Formation of Cyclic Silyl Enol Ethers.

ChemInform ◽  
2010 ◽  
Vol 33 (26) ◽  
pp. no-no
Author(s):  
Chih-Hao Huang ◽  
Sheng-Yueh Chang ◽  
Nung-Sen Wang ◽  
Yeun-Min Tsai
Keyword(s):  
Radical Cyclizations ◽  
Enol Ethers ◽  
Silyl Enol Ethers

Acyl radical cyclizations in synthesis. part 2 further substituent effects on the mode and efficiency of cyclizaion of 6-heptenoyl radicals.

Tetrahedron ◽  
1990 ◽  
Vol 46 (6) ◽  
pp. 2135-2148 ◽  
Author(s):  
David Crich ◽  
K. Angeline Eustace ◽  
Simon M. Fortt ◽  
Timodthy J. Ritchie
Keyword(s):  
Substituent Effects ◽  
Radical Cyclizations ◽  
Acyl Radical

Highly Regioselective Radical Cyclizations of Allenamides

2005 ◽  
Vol 7 (5) ◽  
pp. 775-778 ◽  
Author(s):  
Lichun Shen ◽  
Richard P. Hsung
Keyword(s):  
Radical Cyclizations

ChemInform Abstract: Highly Diastereoselective Radical Cyclizations of Chiral Sulfinimines.

ChemInform ◽  
2014 ◽  
Vol 45 (6) ◽  
pp. no-no
Author(s):  
Elise M. Rochette ◽  
William Lewis ◽  
Al G. Dossetter ◽  
Robert A. Stockman
Keyword(s):  
Radical Cyclizations
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