ChemInform Abstract: Recent Advances in the Enantioselective Synthesis of Chiral Drugs

ChemInform ◽  
2010 ◽  
Vol 28 (46) ◽  
pp. no-no
Author(s):  
E. JUARISTI
Keyword(s):  
Enantioselective Synthesis ◽  
Chiral Drugs ◽  
Recent Advances

Enantioselective Functionalization of Prochiral Cyclobutanones and Cyclobutenones

Synlett ◽  
2021 ◽  
Author(s):  
Memg Wang ◽  
Changxu Zhong ◽  
Ping Lu
Keyword(s):  
Asymmetric Synthesis ◽  
Membered Ring ◽  
Enantioselective Synthesis ◽  
Ring Compounds ◽  
Recent Advances ◽  
Cyclobutane Derivatives

Enantioselective synthesis of cyclobutane derivatives is still a challenging topic in asymmetric synthesis. [2+2]-Cycloaddition and skeleton rearrangement are two primary strategies to this end. Recently, functionalization of cyclobutanones and cyclobutenones, which are readily available via [2+2]-cycloadditions as prochiral substrates, has emerged as a powerful tool to access versatile four-membered ring compounds. Herein, we summarize some recent advances in these areas from our and other groups.

A Concise Enantioselective Synthesis of (S)-Preclamol via Asymmetric Catalytic Negishi Cross-Coupling Reaction

Synlett ◽  
2019 ◽  
Vol 30 (07) ◽  
pp. 860-862 ◽  
Author(s):  
Yun Zhou ◽  
Chunxiao Liu ◽  
Lifeng Wang ◽  
Leng Han ◽  
Shicong Hou ◽  
...  
Keyword(s):  
Total Yield ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Synthetic Approach ◽  
Chiral Drugs ◽  
Asymmetric Catalytic ◽  
Cross Coupling Reaction ◽  
Tertiary Carbon ◽  
Key Steps

A novel, concise, and efficient enantioselective synthesis of (S)-preclamol (87% ee, 51% total yield) has been developed. The key steps of this synthetic approach included cobalt-catalyzed asymmetric catalytic cross-coupling of α-bromo ester with arylzinc and the reduction of chiral ester to diol with a tertiary carbon atom. Moreover, it was demonstrated that our enantioselective Negishi cross-coupling was a powerful tool to construct stereogenic benzylmethyl center in chiral drugs on a gram scale.

Recent Advances in Catalytic Enantioselective Synthesis of Fluorinated α‐ and β‐Amino Acids

2020 ◽  
Vol 362 (22) ◽  
pp. 4763-4793 ◽  
Author(s):  
Xue‐Xin Zhang ◽  
Yang Gao ◽  
Xiao‐Si Hu ◽  
Cong‐Bin Ji ◽  
Yun‐Lin Liu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Enantioselective Synthesis ◽  
Recent Advances

Recent Advances in Organocatalytic Asymmetric Multicomponent Cascade Reactions for Enantioselective Synthesis of Spirooxindoles

2021 ◽  
Author(s):  
Yongchao Wang ◽  
Angel A. Cobo ◽  
Annaliese Franz
Keyword(s):  
Cascade Reactions ◽  
Enantioselective Synthesis ◽  
Asymmetric Catalytic ◽  
Recent Advances

Asymmetric catalytic multicomponent cascade reactions have become indispensable tools for enantioselective construction of spirooxindoles. In recent years, a number of successful strategies have been developed for the synthesis of enantioenriched...

scholarly journals Recent Advances in ω-Transaminase-Mediated Biocatalysis for the Enantioselective Synthesis of Chiral Amines

Catalysts ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 254 ◽  
Author(s):  
Mahesh D. Patil ◽  
Gideon Grogan ◽  
Andreas Bommarius ◽  
Hyungdon Yun
Keyword(s):  
Enantioselective Synthesis ◽  
Chiral Amines ◽  
Recent Advances
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