ChemInform Abstract: Applications of Solid-Phase Synthesis to Drug Discovery

ChemInform ◽  
2010 ◽  
Vol 28 (45) ◽  
pp. no-no
Author(s):  
P. M. COWLEY ◽  
D. C. REES
Keyword(s):  
Drug Discovery ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Solid-Phase Synthesis of Tetramic Acid via Resin-Bound Enol Ethers as a Privileged Scaffold in Drug Discovery

2018 ◽  
Vol 360 (19) ◽  
pp. 3693-3699 ◽  
Author(s):  
Eva Schütznerová ◽  
Allen G. Oliver ◽  
Adam Přibylka ◽  
Viktor Krchňák
Keyword(s):  
Drug Discovery ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Tetramic Acid ◽  
Enol Ethers ◽  
Phase Synthesis ◽  
Privileged Scaffold

Solid-Phase Traceless Synthesis of Selected Nitrogen-Containing Heterocyclic Compounds. The Encore Technique for Directed Sorting of Modular Solid Support

2001 ◽  
Vol 66 (7) ◽  
pp. 1078-1106 ◽  
Author(s):  
Viktor Krchňák ◽  
Jennifer Smith ◽  
Josef Vágner
Keyword(s):  
Drug Discovery ◽  
Hydrogen Atom ◽  
Heterocyclic Compounds ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Support ◽  
Combinatorial Synthesis ◽  
Target Compound ◽  
Phase Synthesis ◽  
Acidic Reagent

The acid lability of electron-rich N-benzylanilines has been exploited in a linker for the traceless solid-phase synthesis of benzimidazoles, 2-aminobenzimidazoles, quinoxalinones and tetrahydroquinoxalines. The target compound precursors were assembled on a solid-phase support derivatized with either a benzylamine or a benzhydrylamine linker. Exposure to an acidic reagent caused cleavage of the C(benzyl)-N(aniline) bond, releasing the product with only a hydrogen atom on the descending nitrogen. The Encore technique for directed sorting on SynPhase Lanterns has been developed and applied to combinatorial synthesis of generic drug discovery libraries.

Tentoxin as a Scaffold for Drug Discovery. Total Solid-Phase Synthesis of Tentoxin and a Library of Analogues

2003 ◽  
Vol 5 (12) ◽  
pp. 2115-2118 ◽  
Author(s):  
Jose C. Jiménez ◽  
Bibiana Chavarría ◽  
Àngel López-Macià ◽  
Miriam Royo ◽  
Ernest Giralt ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Total Solid ◽  
Phase Synthesis

scholarly journals Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents

Molecules ◽  
2011 ◽  
Vol 16 (5) ◽  
pp. 4104-4121 ◽  
Author(s):  
Paweł Zajdel ◽  
Joanna Król ◽  
Katarzyna Grychowska ◽  
Maciej Pawłowski ◽  
Gilles Subra ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis
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