ChemInform Abstract: Efficient Mitomycin C Coupling with Stable p-Nitrophenyl Benzyl Carbonates Using N-Hydroxybenzotriazole as a Catalytic Additive.

ChemInform ◽  
2010 ◽  
Vol 28 (45) ◽  
pp. no-no
Author(s):  
G. M. DUBOWCHIK ◽  
H. D. KING ◽  
K. PHAM-KAPLITA
Keyword(s):  
Mitomycin C ◽  
Catalytic Additive

Efficient mitomycin C coupling with stable p-nitrophenyl-benzyl carbonates using n-hydroxybenzotriazole as a catalytic additive

1997 ◽  
Vol 38 (30) ◽  
pp. 5261-5264 ◽  
Author(s):  
Gene M. Dubowchik ◽  
H. Dalton King ◽  
Kahnie Pham-Kaplita
Keyword(s):  
Mitomycin C ◽  
Catalytic Additive

1570: Combined Mitomycin C and Hyperthermia (SYNERGO) for Patients with Superficial Bladder Cancer (SBC) after Bacillus Calmette-Guerin (BCG) Failure

2007 ◽  
Vol 177 (4S) ◽  
pp. 519-519
Author(s):  
Ofer Nativ ◽  
Renzo Colombo ◽  
Dov Engelstein ◽  
Ofer N. Gofrit ◽  
Thomas Akkad ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Mitomycin C ◽  
Superficial Bladder Cancer ◽  
Bacillus Calmette Guerin ◽  
Bcg Failure

832: Optimized Intravesical Mitomycin C Treatment for Superficial Bladder Cancer: Long-Term Follow-Up

2006 ◽  
Vol 175 (4S) ◽  
pp. 268-269 ◽  
Author(s):  
Jessie L. Au ◽  
Robert A. Badalament ◽  
M. Guillaume Wientjes ◽  
Donn C. Young ◽  
Tong Shen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Mitomycin C ◽  
Superficial Bladder Cancer ◽  
Long Term Follow Up

Erste Ergebnisse – Die gedeckte Sklerotomie unter primärer Anwendung von Mitomycin C 0,02%

2008 ◽  
Vol 225 (S 04) ◽  
Author(s):  
E Karioris ◽  
C Wirbelauer ◽  
H Häberle ◽  
DT Pham
Keyword(s):  
Mitomycin C ◽  
Erste Ergebnisse

Lokale Applikation von Mitomycin C bei Atemwegsstenosen

Pneumologie ◽  
2009 ◽  
Vol 63 (S 01) ◽  
Author(s):  
PC Bauer ◽  
U Sommerwerck ◽  
J Hagmeyer ◽  
F Bonella ◽  
U Costabel
Keyword(s):  
Mitomycin C

Wundmodulation bei der gedeckten Sklerotomie durch Kombination von Mitomycin-C und subkonjunktivalem Avastin

2011 ◽  
Vol 228 (S 02) ◽  
Author(s):  
AM Hoang ◽  
A Berthold ◽  
A Just ◽  
DT Pham ◽  
C Wirbelauer
Keyword(s):  
Mitomycin C

The Effect of Mitomycin C on Platelet Aggregation and Adenosine 3′, 5′-Monophosphate Metabolism

1978 ◽  
Vol 39 (01) ◽  
pp. 177-185 ◽  
Author(s):  
Shuichi Hashimoto ◽  
Sachiko Shibata ◽  
Bonro Kobayashi
Keyword(s):  
Platelet Aggregation ◽  
Cyclic Amp ◽  
Mitomycin C ◽  
Blood Platelets ◽  
Adenosine Diphosphate ◽  
Cellular Membrane ◽  
Adenyl Cyclase ◽  
Cyclic Amp Phosphodiesterase ◽  
Membrane Structure And Function ◽  
And Function

SummaryThe effect of Mitomycin C on aggregation, adenosine 3′, 5′-monophosphate (cyclic AMP) metabolism and reactions induced by thrombin was studied in rabbit platelets. Mitomycin C inhibited the platelet aggregation induced by adenosine diphosphate or thrombin. The level of radioactive cyclic AMP derived from 8-14C adenine or 8-14C adenosine increased after incubating intact platelets with Mitomycin G. Formation of radioactive adenosine triphosphate also increased though mitochondrial oxidation was not stimulated. Similar effect was observed also in rabbit liver. Mitomycin C failed to stimulate platelet adenyl cyclase but inhibited cyclic AMP phosphodiesterase in the absence of theophylline. In the platelets preincubated with Mitomycin C, thrombin-induced inhibition of adenyl cyclase, stimulation of membrane-bound cyclic AMP phosphodiesterase, and release of 250,000 dalton protein from platelet membranes were prevented. These results suggest that Mitomycin C will affect cellular membrane structure and function, and this extranuclear effect of Mitomycin C will lead to inhibition of aggregation in blood platelets.

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