ChemInform Abstract: Enzymatic Coupling of α,α-Dialkyl Amino Acids Using Inverse Substrates as Acyl Donors.

ChemInform ◽  
2010 ◽  
Vol 28 (28) ◽  
pp. no-no
Author(s):  
H. SEKIZAKI ◽  
K. ITOH ◽  
E. TOYOTA ◽  
K. TANIZAWA
Keyword(s):  
Amino Acids ◽  
Dialkyl Amino Acids ◽  
Acyl Donors

Enzymatic coupling of α,α-dialkyl amino acids using inverse substrates as acyl donors

1997 ◽  
Vol 38 (10) ◽  
pp. 1777-1780 ◽  
Author(s):  
Haruo Sekizaki ◽  
Kunihiko Itoh ◽  
Eiko Toyota ◽  
Kazutaka Tanizawa
Keyword(s):  
Amino Acids ◽  
Dialkyl Amino Acids ◽  
Acyl Donors

3-Benzoyl-2-isopropyl-4-alkyloxazolidin-5-ones as Efficient and Inexpensive Sources of Enantiopure ?,?-Dialkyl ?-Amino Acids and ?,?-Dialkyl ?,?-Diaminopropionic Acids.

ChemInform ◽  
2005 ◽  
Vol 36 (21) ◽  
Author(s):  
Susana Rojas-Lima ◽  
Omar Tellez-Zenteno ◽  
Heraclio Lopez-Ruiz ◽  
Lizeth Loubet-Gonzalez ◽  
Alejandro Alvarez-Hernandez
Keyword(s):  
Amino Acids ◽  
Dialkyl Amino Acids

Conformational effects of chiral α,α-dialkyl amino acids I. C-Terminal tetrapeptides of emerimicin containing α-ethylalanine

2009 ◽  
Vol 32 (6) ◽  
pp. 544-555 ◽  
Author(s):  
GARLAND R. MARSHALL ◽  
JOHN D. CLARK ◽  
JAMES B. DUNBAR ◽  
G. DAVID SMITH ◽  
JANUSZ ZABROCKI ◽  
...  
Keyword(s):  
Amino Acids ◽  
Conformational Effects ◽  
Dialkyl Amino Acids

Conformational analysis and helical preferences of normal and ?,?-dialkyl amino acids

Biopolymers ◽  
1990 ◽  
Vol 30 (5-6) ◽  
pp. 533-546 ◽  
Author(s):  
Edward E. Hodgkin ◽  
John D. Clark ◽  
Katherine R. Miller ◽  
Garland R. Marshall
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Dialkyl Amino Acids

Electronic and ESR Spectra of Copper(II) Complexes with N,N-Dialkyl Amino Acids

1992 ◽  
Vol 613 (7) ◽  
pp. 132-136 ◽  
Author(s):  
Nevenka Pauli? ◽  
Vesna N�thig-Laslo ◽  
Vladimir Simeon
Keyword(s):  
Amino Acids ◽  
Esr Spectra ◽  
Dialkyl Amino Acids

scholarly journals Factors governing helical preference of peptides containing multiple alpha,alpha-dialkyl amino acids.

1990 ◽  
Vol 87 (1) ◽  
pp. 487-491 ◽  
Author(s):  
G. R. Marshall ◽  
E. E. Hodgkin ◽  
D. A. Langs ◽  
G. D. Smith ◽  
J. Zabrocki ◽  
...  
Keyword(s):  
Amino Acids ◽  
Dialkyl Amino Acids

Facile synthesis of protected dipeptide acids containing C-terminal α,α-dialkyl amino acids.

1991 ◽  
Vol 32 (28) ◽  
pp. 3407-3408 ◽  
Author(s):  
Frank Bambino ◽  
Robert T.C. Brownlee ◽  
Francis C.K. Chiu
Keyword(s):  
Amino Acids ◽  
Facile Synthesis ◽  
Dialkyl Amino Acids

scholarly journals One-Pot Synthesis of Diverse dl-Configuration Dipeptides by a Streptomyces d-Stereospecific Amidohydrolase

2011 ◽  
Vol 77 (23) ◽  
pp. 8209-8218 ◽  
Author(s):  
Jiro Arima ◽  
Hirokazu Usuki ◽  
Tadashi Hatanaka ◽  
Nobuhiro Mori
Keyword(s):  
Amino Acids ◽  
Reaction Mechanism ◽  
Methyl Ester ◽  
Specific Inhibitor ◽  
Benzyl Ester ◽  
Synthetic Activity ◽  
One Pot ◽  
Content Type ◽  
Acyl Acceptors ◽  
Acyl Donors

ABSTRACTThe synthesis of diversedl-configuration dipeptides in a one-pot reaction was demonstrated by using a function of the aminolysis reaction of ad-stereospecific amidohydrolase fromStreptomycessp., a clan SE, S12 family peptidase categorized as a peptidase withd-stereospecificity. The enzyme was able to use various aminoacyl derivatives, includingl-aminoacyl derivatives, as acyl donors and acceptors. Investigations of the specificity of the peptide synthetic activity revealed that the enzyme preferentially usedd-aminoacyl derivatives as acyl donors. In contrast,l-amino acids and their derivatives were preferentially used as acyl acceptors. Consequently, the synthesized dipeptides had adl-configuration whend- andl-aminoacyl derivatives were mixed in a one-pot reaction. This report also describes that the enzyme produced cyclo(d–Pro-l-Arg), a specific inhibitor of family 18 chitinase, with a conversion rate ford-Pro benzyl ester andl-Arg methyl ester to cyclo(d-Pro–l-Arg) of greater than 65%. Furthermore, based on results of cyclo(d-Pro–l-Arg) synthesis, we propose a reaction mechanism for cyclo(d-Pro–l-Arg) production.

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