ChemInform Abstract: Total Synthesis of Zaragozic Acid A (Squalestatin S1) (I). Degradation to a Relay Compound (II) and Reassembly of the Natural Product.

ChemInform ◽  
2010 ◽  
Vol 28 (18) ◽  
pp. no-no
Author(s):  
D. STOERMER ◽  
S. CARON ◽  
C. H. HEATHCOCK
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Zaragozic Acid ◽  
Compound Ii

The Bakerian Lecture: Some approaches to the synthesis of tetracycline

1970 ◽  
Vol 319 (1537) ◽  
pp. 145-163
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Natural Product ◽  
Tetracycline Antibiotics ◽  
Tetracycline Antibiotic ◽  
Important Group ◽  
Naturally Occurring ◽  
Compound Ii

Tetracycline (I, R 1 = Me, R 2 = R 3 = H) is a member of the important group of tetracycline antibiotics. Other members of this group of medicinal importance are aureomycin (I, R 1 = Me, R 2 = H, R 3 = Cl), terramycin (I, R 1 = Me, R 2 = OH, R 3 = H) and 6-demethyltetracycline (I, R 1 = R 2 = R 3 = H). All these compounds represent challenging objectives for total synthesis. The total synthesis of 6-demethyl-6-deoxytetracycline was reported some years ago (Woodward 1963; Korst et al . 1968). Although this is not a natural product it does have significant biological activity. The first synthesis of a naturally occurring tetracycline antibiotic was effected only recently (Guaevich et al . 1967). It involved the synthesis of the compound (II) which had already been converted into tetracycline (I, R 1 = Me, R 2 = R 3 = H) (Scott & Bedford 1962; Schach von Wittenau 1964). Finally, a beautiful total synthesis of terramycin (I, R 1 = Me, R 2 = OH, R 3 = H), not involving any relay, has recently been described (Muxfeldt et al . 1968). All these syntheses start with ring D or with rings C and D and then add stepwise the elements of rings A and B.

Progress Toward The Total Synthesis Of The Marine Natural Product Karlotoxin 5

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Albadry ◽  
Y Zou ◽  
Y Takahashi ◽  
A Waters ◽  
M Hossein ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Marine Natural Product

Total Synthesis of the Antitumor Depsipeptide FE399 and its S-Benzyl Derivative: A Macrolactamization Approach

2020 ◽  
Author(s):  
Takayuki Tonoi ◽  
Miyuki Ikeda ◽  
Teruyuki Sato ◽  
Ryo Kawahara ◽  
Takatsugu Murata ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Total Synthesis ◽  
Natural Product ◽  
Condensation Reaction ◽  
Practical Method ◽  
Equilibrium Mixture ◽  
Conformational Isomers ◽  
Single Isomer

<div>An efficient and practical method for the synthesis of (9R,14R,17R)-FE399, a novel antitumor bicyclic depsipeptide, was developed. A 2-methyl-6-nitrobenzoic anhydride (MNBA)-mediated dehydration condensation reaction was effectively employed for the formation of the 16-membered macrocyclic depsipeptide moiety of FE399. FE399 was found to exist as an inseparable equilibrium mixture of conformational isomers; the mixture was quantitatively transformed into the corresponding S-benzyl product and isolated as a single isomer. Thus, we could confirm that the molecular structure of FE399 obtained by this method is identical to that of the natural product.</div>

A One-Pot Chemoenzymatic Synthesis of (2S,4R)-4-Methylproline Enables the First Total Synthesis of Antiviral Lipopeptide Cavinafungin B

2018 ◽  
Author(s):  
Christian R. Zwick ◽  
Hans Renata
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Complex Molecule ◽  
Molecular Target ◽  
Chemoenzymatic Synthesis ◽  
General Strategy ◽  
One Pot

We report an efficient ten-step synthesis of antiviral natural product cavinafungin B in 37% overall yield. By leveraging a one-pot chemoenzymatic synthesis of (2S,4R)-4-methylproline and oxazolidine-tethered (Rink-Boc-ATG-resin) SPPS methodology, the assembly of our molecular target could be conducted in an efficient manner.This general strategy could prove amenable to the construction of other natural and unnatural linear lipopeptides. The value of incorporating biocatalytic steps in complex molecule synthesis is highlighted by this work.

Convergent Total Synthesis of Principinol D, a Rearranged Kaurane Diterpenoid

2019 ◽  
Author(s):  
Timothy Newhouse ◽  
Aneta Turlik ◽  
Yifeng Chen ◽  
Anthony Scruse
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Late Stage ◽  
Membered Ring ◽  
Entry Point ◽  
Ketone Reduction ◽  
Coupling Approach

<div> <p>The total synthesis of principinol D, a rearranged kaurane diterpenoid, is reported. This grayanane natural product is constructed via a convergent fragment coupling approach, wherein the central 7-membered ring is synthesized at a late stage. The bicyclo[3.2.1]octane fragment is accessed by a Ni-catalyzed α-vinylation reaction. Strategic reductions include a diastereoselective SmI<sub>2</sub>-mediated ketone reduction with PhSH and a new protocol for selective ester reduction in the presence of ketones. The convergent strategy reported herein may be an entry point to the larger class of kaurane diterpenoids.</p> </div>

A Short Synthesis of (+)-Brefeldin C via Enantioselective Radical Hydroalkynylation

2019 ◽  
Author(s):  
Lars Gnägi ◽  
Severin Vital Martz ◽  
Daniel Meyer ◽  
Robin Marc Schärer ◽  
Philippe Renaud
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Oxidation State ◽  
Single Step ◽  
Radical Process ◽  
Target Molecule ◽  
Short Synthesis ◽  
The One

<div><div><div><div><p>A very concise total synthesis of (+)-brefeldin C starting from 2-furanylcyclopentene is described. This approach is based on an unprecedented enantioselective radical hydroalkynylation process to introduce the two cyclopentane stereocenters in a single step. The use of a furan substituent allows to achieve a high trans diastereoselectivity during the radical process and it contains the four carbon atoms C1–C4 of the natural product in an oxidation state closely related to the one of the target molecule. The eight-step synthesis require six product purifications and it provides (+)-brefeldin C in 18% overall yield.</p></div></div></div></div>

ChemInform Abstract: Total Synthesis of the Antitumor Natural Product Polycarcin V and Evaluation of Its DNA Binding Profile.

ChemInform ◽  
2014 ◽  
Vol 45 (49) ◽  
pp. no-no
Author(s):  
Xiao Cai ◽  
Kevin Ng ◽  
Harmanpreet Panesar ◽  
Seong-Jin Moon ◽  
Maria Paredes ◽  
...  
Keyword(s):  
Dna Binding ◽  
Total Synthesis ◽  
Natural Product ◽  
Binding Profile
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