ChemInform Abstract: Concave Reagents. Part 20. Sterically Shielded m-Terphenyls as Selective Agents in General Protonations.

ChemInform ◽  
2010 ◽  
Vol 28 (10) ◽  
pp. no-no
Author(s):  
U. LUENING ◽  
H. BAUMGARTNER ◽  
C. MANTHEY ◽  
B. MEYNHARDT
Keyword(s):  
Selective Agents ◽  
Concave Reagents

Concave Reagents. 20. Sterically Shieldedm-Terphenyls as Selective Agents in General Protonations1

1996 ◽  
Vol 61 (22) ◽  
pp. 7922-7926 ◽  
Author(s):  
U. Lüning ◽  
H. Baumgartner ◽  
C. Manthey ◽  
B. Meynhardt
Keyword(s):  
Selective Agents ◽  
Concave Reagents

ChemInform Abstract: Concave Reagents. Part 4. Protonation of Nitronate Anions via Concave Pyridines. Stereoselective C-Protonation versus Nef Reaction.

ChemInform ◽  
1990 ◽  
Vol 21 (15) ◽  
Author(s):  
U. LUENING ◽  
R. BAUMSTARK ◽  
M. MUELLER ◽  
C. WANGNICK ◽  
F. SCHILLINGER
Keyword(s):  
Nef Reaction ◽  
Concave Reagents

scholarly journals Influence of Selective Agents (EMJH-STAFF), Sample Filtration and pH on Leptospira Interrogans Serovar Icterohaemorrhagiae Cultivation and Isolation from Swine Urine

2021 ◽  
Vol 8 (6) ◽  
pp. 90
Author(s):  
Romana Steinparzer ◽  
Tamara Mair ◽  
Christine Unterweger ◽  
Adi Steinrigl ◽  
Friedrich Schmoll
Keyword(s):  
Diagnostic Tests ◽  
Urine Samples ◽  
Epidemiological Surveillance ◽  
Leptospira Interrogans ◽  
Sample Storage ◽  
Clinical Specimens ◽  
Negative Results ◽  
Swine Urine ◽  
Selective Agents ◽  
Phosphate Buffered Saline

Leptospira spp. cause the zoonotic disease leptospirosis, which occurs in numerous mammalians worldwide. Isolation is still important for serotyping and genotyping of Leptospira, which in turn is essential for epidemiological surveillance of leptospirosis and the development of diagnostic tests and vaccines. However, isolation of Leptospira from clinical specimens is inherently insensitive. This study was conducted to examine the influence of selective agents, sample filtration, sample pH and the use of phosphate buffered saline (PBS) buffer for sample storage to improve the success of cultivation and isolation of Leptospira interrogans serovar Icterohaemorrhagiae from swine urine. EMJH (Ellinghausen McCullough, Johnson and Harris) medium including the selective agents sulfamethoxazole, trimethoprim, amphotericin, fosfomycin and 5-fluorouracil (STAFF) increased the success of Leptospira isolation from spiked swine urine samples. Sample filtration yielded only negative results. Isolation in EMJH-STAFF was successful from swine urine with a density as low as 104 Leptospira/mL, and urine with pH ≤ 7 impaired the cultivation rate. Cultivation and isolation were not improved by the addition of PBS to spiked urine samples prior to storage for 24 h at 4 °C. The results of the study demonstrate that cultivation and isolation of leptospires from swine urine can be improved by enhanced methods.

scholarly journals The Effect of Vicinal Difluorination on the Conformation and Potency of Histone Deacetylase Inhibitors

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3974
Author(s):  
A. Daryl Ariawan ◽  
Flora Mansour ◽  
Nicole Richardson ◽  
Mohan Bhadbhade ◽  
Junming Ho ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Hdac Inhibitors ◽  
Molecular Conformations ◽  
Fluorinated Analogs ◽  
Selective Agents ◽  
Isoform Selectivity

Histone deacetylase enzymes (HDACs) are potential targets for the treatment of cancer and other diseases, but it is challenging to design isoform-selective agents. In this work, we created new analogs of two established but non-selective HDAC inhibitors. We decorated the central linker chains of the molecules with specifically positioned fluorine atoms in order to control the molecular conformations. The fluorinated analogs were screened against a panel of 11 HDAC isoforms, and minor differences in isoform selectivity patterns were observed.

Concave Reagents, 71) Concave Benzoic Acids

1991 ◽  
Vol 124 (2) ◽  
pp. 397-402 ◽  
Author(s):  
Ulrich Lüning ◽  
Carsten Wangnick ◽  
Karl Peters ◽  
Hans Georg Von Schnering
Keyword(s):  
Benzoic Acids ◽  
Concave Reagents

The adaptive significance of dorsal spine variation in the fourspine stickleback, Apeltes quadracus, I. Geographic variation in spine number

1984 ◽  
Vol 62 (7) ◽  
pp. 1329-1339 ◽  
Author(s):  
D. M. Blouw ◽  
D. W. Hagen
Keyword(s):  
Genetic Differentiation ◽  
Geographic Variation ◽  
Adaptive Significance ◽  
Maritime Provinces ◽  
Selective Agents ◽  
Apeltes Quadracus ◽  
Remarkable Result ◽  
Fourspine Stickleback ◽  
Very High Frequencies ◽  
Spine Number

The goal of our research is to investigate the adaptive significance of a polymorphism for the number of dorsal spines in Apeltes quadracus, the fourspine stickleback. One approach we take is to search for correlations between phenotypes and environments. To this end we collected Apeltes and scored environments at 570 sites in the Maritime Provinces of Canada. In this paper we describe geographic variation in spine number and evaluate how reliably it reflects genetic differentiation among sites. Morph frequencies are highly differentiated geographically. We describe four kinds of variation: relatively constant frequencies, gentle clines, steep clines, and remarkably abrupt changes (called "intrusions") where frequencies at some sites differ greatly from those at a larger number of surrounding sites. Most of the variation among sites is due to differences in the frequencies of the four- and five-spined morphs. However, a remarkable result is that the three-spined morph, which is rare or absent elsewhere in the range, reaches very high frequencies in Bras D'Or Lake. Our evidence suggests this variation among sites reflects substantial genetic differentiation. The differentiation is favorable for detecting selective agents, if indeed selection is responsible.

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