ChemInform Abstract: Active Vitamin D Analogues - Important and Various Roles by Medicinal Chemists During the Course of Development of Promising Candidates as Useful Medicines

ChemInform ◽  
2010 ◽  
Vol 27 (33) ◽  
pp. no-no
Author(s):  
N. KUBODERA
Keyword(s):  
Vitamin D ◽  
Active Vitamin ◽  
Active Vitamin D ◽  
Vitamin D Analogues

Potentiating effects of nonactive/active vitamin D analogues and ketoconazole in parathyroid cells

2007 ◽  
Vol 66 (3) ◽  
pp. 399-404 ◽  
Author(s):  
Ulrika Segersten ◽  
Peyman Björklund ◽  
Per Hellman ◽  
Göran Åkerström ◽  
Gunnar Westin
Keyword(s):  
Vitamin D ◽  
Active Vitamin ◽  
Active Vitamin D ◽  
Vitamin D Analogues

scholarly journals Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Tomoya Soma ◽  
Ryotaro Iwasaki ◽  
Yuiko Sato ◽  
Tami Kobayashi ◽  
Eri Ito ◽  
...  
Keyword(s):  
Vitamin D ◽  
Tooth Extraction ◽  
Dental Treatment ◽  
Osteonecrosis Of The Jaw ◽  
Active Vitamin ◽  
Active Vitamin D ◽  
Vitamin D Analogues ◽  
Extraction Site ◽  
Treatment Administration ◽  
Anti Inflammatory

AbstractInvasive dental treatment such as tooth extraction following treatment with strong anti-bone resorptive agents, including bisphosphonates and denosumab, reportedly promotes osteonecrosis of the jaw (ONJ) at the extraction site, but strategies to prevent ONJ remain unclear. Here we show that in mice, administration of either active vitamin D analogues, antibiotics or anti-inflammatory agents can prevent ONJ development induced by tooth extraction during treatment with the bisphosphonate zoledronate. Specifically, tooth extraction during treatment with zoledronate induced osteonecrosis in mice, but administration of either 1,25(OH)2D3 or ED71, both active vitamin D analogues, significantly antagonized osteonecrosis development, even under continuous zoledronate treatment. 1,25(OH)2D3 or ED71 administration also significantly inhibited osteocyte apoptosis induced by tooth extraction and bisphosphonate treatment. Administration of either active vitamin D analogue significantly inhibited elevation of serum inflammatory cytokine levels in mice in response to injection of lipopolysaccharide, an infection mimetic. Furthermore, administration of either anti-inflammatory or antibiotic reagents significantly blocked ONJ development following tooth extraction and zoledronate treatment. These findings suggest that administration of active vitamin D, anti-inflammatory agents or antibiotics could prevent ONJ development induced by tooth extraction in patients treated with zoledronate.

scholarly journals Active vitamin D supplementation and COVID-19 infections: review

2021 ◽  
Author(s):  
Nakhoul Farid ◽  
Nakhoul Rola ◽  
Elias A. T. Koch ◽  
Nakhoul Nakhoul
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Active Vitamin ◽  
Active Vitamin D
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