ChemInform Abstract: Fflash Photolysis Study for Reversible Addition Reactions of Thiyl Radicals with Olefins and Acetylenes

ChemInform ◽  
2010 ◽  
Vol 26 (28) ◽  
pp. no-no
Author(s):  
O. ITO
Keyword(s):  
Addition Reactions ◽  
Thiyl Radicals ◽  
Reversible Addition

scholarly journals Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4357 ◽  
Author(s):  
Schöneich
Keyword(s):  
Hydrogen Atom Transfer ◽  
Chemical Degradation ◽  
Addition Reactions ◽  
Thiyl Radicals ◽  
Pharmaceutical Protein ◽  
Pharmaceutical Proteins ◽  
Cross Links ◽  
Human And Mouse ◽  
Protein Pharmaceuticals

Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. These processes can lead to the epimerization of amino acids, as well as the formation of various cleavage products and cross-links. Examples are presented for human insulin, human and mouse growth hormone, and monoclonal antibodies.

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