ChemInform Abstract: Synthesis of Biologically Active Vitamin E (α-Tocopherol) Esters

ChemInform ◽  
2010 ◽  
Vol 24 (5) ◽  
pp. no-no
Author(s):  
R. P. EVSTIGNEEVA ◽  
E. I. SAKHAROVA
Keyword(s):  
Vitamin E ◽  
Biologically Active ◽  
Active Vitamin

scholarly journals Changes in Vitamin E and β-Carotene Contents in Various Edible Cassava Leaves (Manihot esculenta Crantz) of Different Ages across Multiple Seasons

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Alphonse Laya ◽  
Benoît B. Koubala
Keyword(s):  
Vitamin E ◽  
Biologically Active ◽  
Leafy Vegetables ◽  
Active Vitamin ◽  
Total Vitamin ◽  
Manihot Esculenta Crantz ◽  
Liquid Chromatograph ◽  
Cassava Leaves ◽  
Significant Difference ◽  
Different Ages

Vitamin E and carotenoids belong to a group of bioactive compounds that have an important effect on human health. The present study aims to investigate for the first time the concentration of vitamin E, α-, γ-, and δ-tocopherol, and β-carotene in edible cassava leaves during different ages. The analysis was performed using colorimetry and high-performance liquid chromatograph (HPLC) methods. A significant difference was found among α-, γ-, and δ-tocopherol concentrations in leaves; γ- and α-tocopherol isomer contents were the predominant in amount, respectively. Among the leaves, AD variety harvested at 6 months after planting (MAP) was the highest in total vitamin E (222 μgα-TE/g). However, the highest γ-tocopherol content (2782 μg/100g) and the content of biologically active vitamin E (1244 μg/100g) were found in EN variety at 6MAP, whereas the highest value (42 μg/g) of β-carotene was found in AD variety at 12MAP. Total vitamin E and tocopherol isomers composition varied among varieties and seasons as did β-carotene. The effects of varieties and harvest ages on the biosynthesis regulation of these compounds were confirmed by principal component analysis (F1x F2: 74.34%). Edible cassava leaves can be considered as sources of vitamin E for natural dietary antioxidant during different ages, and the best time to harvest EN and AD varieties is at 6MAP on the basis of α-tocopherol equivalent or content of biologically active vitamin E content, and EN and AD varieties performed the overall best. Thus, the edible cassava leaves are among the leafy vegetables that could be helpful to suggest as a part of daily meal for health benefits and pharmaceutical purposes.

ChemInform Abstract: Synthesis of a Biologically Active Vitamin-D2 Metabolite (I).

ChemInform ◽  
2010 ◽  
Vol 24 (28) ◽  
pp. no-no
Author(s):  
S. C. CHOUDHRY ◽  
P. S. BELICA ◽  
D. L. COFFEN ◽  
A. FOCELLA ◽  
H. MAEHR ◽  
...  
Keyword(s):  
Biologically Active ◽  
Vitamin D2 ◽  
Active Vitamin

scholarly journals STUDY OF THE KINETICS OF ENZYMATIC OXIDATION OF 2,3,6-TRIMETHYLPHENOL IN THE PRESENCE OF IMMOBILIZED PEROXIDASE

2020 ◽  
pp. 7-15
Author(s):  
Ольга Валентиновна Гребенникова ◽  
Александрина Михайловна Сульман ◽  
Владимир Петрович Молчанов ◽  
Елена Михайловна Михайлова ◽  
Ирина Павловна Шкилева ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Vitamin E ◽  
Magnetic Nanoparticles ◽  
Biologically Active ◽  
Enzymatic Oxidation ◽  
Stable Operation ◽  
Substituted Phenols ◽  
Active Compounds ◽  
Enzyme Systems ◽  
Kinetics Of

В работе изучался процесс окисления 2,3,6-триметилфенола в присутствии иммобилизованной пероксидазы корня хрена. В результате такого окисления был получен полупродукт витамина Е (2,3,5-триметилгидрохинон). Иммобилизация фермента проводилась на магнитные наночастицы, на SiO и AlO. Все исследованные биокатализаторы показали стабильную работу в процессе окисления 2,3,6-триметилфенола с помощью пероксида водорода. Таким образом, синтезированные биокаталитические ферментные системы могут успешно применяться в качестве альтернативных катализаторов окисления замещенных фенолов с целью получения биологически активных соединений класса витаминов. We studied the oxidation of 2,3,6-trimethylphenol in the presence of immobilized horseradish root peroxidase. As a result of this oxidation, a semi-product of vitamin E (2,3,5-trimethylhydroquinone) was obtained. The enzyme was immobilized on magnetic nanoparticles, on SiO and AlO. All the studied biocatalysts showed stable operation during the oxidation of 2,3,6-trimethylphenol using hydrogen peroxide. Thus, the synthesized biocatalytic enzyme systems can be successfully used as alternative catalysts for the oxidation of substituted phenols in order to obtain biologically active compounds of the vitamin class.

scholarly journals Role of antioxidants in electro catalysis of cytochrome P450 3A4

2014 ◽  
Vol 60 (2) ◽  
pp. 224-234 ◽  
Author(s):  
V.V. Shumyantseva ◽  
A.A. Makhova ◽  
T.V. Bulko ◽  
E.V. Shich ◽  
V.G. Kukes ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Catalytic Activity ◽  
Vitamin E ◽  
Vitamin A ◽  
Antioxidant Properties ◽  
Biologically Active ◽  
Catalytic Current ◽  
Electrochemical Approach ◽  
Electro Catalysis ◽  
Clinical Experiments

The electrochemical analysis of cytochrome Р450 3А4 catalytic activity has shown that vitamins C, A and Е influence on electron transfer and Fe3+/Fe2+ reduction process of cytochrome Р450 3А4. These data allow to assume possibility of cross effects and interference of vitamins-antioxidants with drugs metabolised by cytochrome Р450 3А4, at carrying out of complex therapy. This class of vitamins shows antioxidant properties that lead to increase of the cathodic current corresponding to heme reduction of this functionally significant haemoprotein. Ascorbic acid of 0.028-0.56 mM concentration stimulates cathodic peak (an electrochemical signal) of cytochrome Р450 3А4. At the presence of diclofenac (Voltaren) - a typical substrate of cytochrome Р450 3А4 - the increase growth of a catalytic current testifying to an electrocatalysis and stimulating action of ascorbic acid is observed. In the presence of vitamins A and Е also is registered dose-dependent (in a range of 10-100 M) increase in a catalytic current of cytochrome Р450 3А4: the maximum increase corresponds to 229 ± 20% for 100 M of vitamin A, and 162±10% for 100 M of vitamin E. Vitamin E in the presence of P450’s inhibitor itraconazole doesn't give essential increase in a reductive current, unlike retinol (vitamin A). This effect can manifest substrate properties of tocopherol (vitamin E). The electrochemical approach for the analysis of catalytic activity of cytochrome Р450 3А4 and studies of influence of biologically active compounds on an electrocatalysis is the sensitive and effective sensor approach, allowing to use low concentration of protein on an electrode (till 10-15 mol/electrode), to carry out the analysis without participation of protein redox partners, and to reveal drug-drug or drug-vitamins interaction in pre-clinical experiments.

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