ChemInform Abstract: Asymmetric Michael Addition of Chiral Enaminoesters to Phenyl Vinyl Sulfone and 1,1-Bis(phenylsulfonyl)ethylene.

ChemInform ◽  
2010 ◽  
Vol 23 (50) ◽  
pp. no-no
Author(s):  
S. PINHEIRO ◽  
A. GUINGANT ◽  
D. DESMAELE ◽  
J. D'ANGELO
Keyword(s):  
Michael Addition ◽  
Vinyl Sulfone ◽  
Asymmetric Michael Addition ◽  
Phenyl Vinyl

Asymmetric Michael addition of chiral enaminoesters to phenyl vinyl sulfone and 1,1-bis(phenylsulfonyl)ethylene

1992 ◽  
Vol 3 (8) ◽  
pp. 1003-1006 ◽  
Author(s):  
Sergio Pinheiro ◽  
André Guinganta ◽  
Didier Desmaële ◽  
Jean d'Angelo
Keyword(s):  
Michael Addition ◽  
Vinyl Sulfone ◽  
Asymmetric Michael Addition ◽  
Phenyl Vinyl

scholarly journals A novel LC-MS method development and validation for the determination of phenyl vinyl sulfone in eletriptan hydrobromide

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Indhu Priya Mabbu ◽  
G. Sumathi ◽  
N. Devanna
Keyword(s):  
Method Development ◽  
Limit Of Detection ◽  
Vinyl Sulfone ◽  
Limit Of Quantification ◽  
Relative Standard ◽  
Pressure Chemical Ionization ◽  
Pressure Chemical ◽  
Development And Validation ◽  
Phenyl Vinyl

Abstract Background The aim of the present method is to develop and validate a specific, sensitive, precise, and accurate liquid chromatography-mass spectrometry (LC-MS) method for the estimation of the phenyl vinyl sulfone in the eletriptan hydrobromide. The effective separation of the phenyl vinyl sulfone was achieved by the Symmetry C18 (50 × 4.6 mm, 3.5 μm) column and a mobile phase composition of 0.1%v/v ammonia buffer to methanol (5:95 v/v), using 0.45 ml/min flow rate and 20 μl of injection volume, with methanol used as diluent. The phenyl vinyl sulfone was monitored on atomic pressure chemical ionization mode mass spectrometer with positive polarity mode. Results The retention time of phenyl vinyl sulfone was found at 2.13 min. The limit of detection (LOD) and limit of quantification (LOQ) were observed at 1.43 ppm and 4.77 ppm concentration respectively; the linear range was found in the concentration ranges from 4.77 to 27.00 ppm with regression coefficient of 0.9990 and accuracy in the range of 97.50–102.10%. The percentage relative standard deviation (% RSD) for six replicates said to be injections were less than 10%. Conclusion The proposed method was validated successfully as per ICH guidelines. Hence, this is employed for the determination of phenyl vinyl sulfone in the eletriptan hydrobromide.

Pyrrolidinyl-Camphor Derivatives as a New Class of Organocatalyst for Direct Asymmetric Michael Addition of Aldehydes and Ketones to β-Nitroalkenes

2010 ◽  
Vol 16 (23) ◽  
pp. 7030-7038 ◽  
Author(s):  
Ying-Fang Ting ◽  
Chihliang Chang ◽  
Raju Jannapu Reddy ◽  
Dhananjay R. Magar ◽  
Kwunmin Chen
Keyword(s):  
Michael Addition ◽  
New Class ◽  
Asymmetric Michael Addition ◽  
Aldehydes And Ketones ◽  
Camphor Derivatives

ChemInform Abstract: Asymmetric Michael Addition of Ketones to Nitroolefins: Pyrrolidinyl-oxazole-carboxamides as New Efficient Organocatalysts.

ChemInform ◽  
2015 ◽  
Vol 46 (12) ◽  
pp. no-no
Author(s):  
Ahmed Kamal ◽  
Manda Sathish ◽  
Vunnam Srinivasulu ◽  
Jadala Chetna ◽  
Kunta Chandra Shekar ◽  
...  
Keyword(s):  
Michael Addition ◽  
Asymmetric Michael Addition

scholarly journals Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins

2017 ◽  
Vol 13 ◽  
pp. 612-619 ◽  
Author(s):  
Alejandro Castán ◽  
Ramón Badorrey ◽  
José A Gálvez ◽  
María D Díaz-de-Villegas
Keyword(s):  
Michael Addition ◽  
Bulky Substituent ◽  
Asymmetric Michael Addition ◽  
Iodination Reaction ◽  
Chiral Imines ◽  
New Compounds ◽  
The Michael Addition

New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R)-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction. The new compounds were found to be effective organocatalysts for the Michael addition of aldehydes to nitroolefins and enantioselectivities up to 85% ee were achieved.

Asymmetric Michael Addition Induced by (R)-tert-Butanesulfinamide and Syntheses of Chiral Pyrazolidinone Derivatives

2016 ◽  
Vol 81 (21) ◽  
pp. 10506-10516 ◽  
Author(s):  
Hong-Xiu Huang ◽  
Hui-Jing Wang ◽  
Ling Tan ◽  
Shu-Qing Wang ◽  
Pei Tang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Asymmetric Michael Addition

ChemInform Abstract: Catalytic Asymmetric Michael Addition of Nitromethane to Enones Controlled by (R)-LPB.

ChemInform ◽  
2010 ◽  
Vol 29 (52) ◽  
pp. no-no
Author(s):  
K. FUNABASHI ◽  
Y. SAIDA ◽  
M. KANAI ◽  
T. ARAI ◽  
H. SASAI ◽  
...  
Keyword(s):  
Michael Addition ◽  
Asymmetric Michael Addition ◽  
Catalytic Asymmetric

ChemInform Abstract: Asymmetric Michael Addition of Thiols to β-Nitrostyrenes Using a Novel Phenylpyrrolidine-Based Urea Catalyst.

ChemInform ◽  
2015 ◽  
Vol 46 (22) ◽  
pp. no-no
Author(s):  
Souichirou Kawazoe ◽  
Kazuki Yoshida ◽  
Yuichi Shimazaki ◽  
Takeshi Oriyama
Keyword(s):  
Michael Addition ◽  
Asymmetric Michael Addition
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