ChemInform Abstract: Montmorillonite Clay as Condensing Agent in Pechmann Reaction for the Synthesis of Coumarin Derivatives.

ChemInform ◽  
2010 ◽  
Vol 23 (49) ◽  
pp. no-no
Author(s):  
G. K. BISWAS ◽  
K. BASU ◽  
A. K. BARUA ◽  
P. BHATTACHARYYA
Keyword(s):  
Montmorillonite Clay ◽  
Coumarin Derivatives ◽  
Pechmann Reaction

ChemInform Abstract: Pechmann Reaction in the Synthesis of Coumarin Derivatives

ChemInform ◽  
2015 ◽  
Vol 46 (22) ◽  
pp. no-no
Author(s):  
Majid M. Heravi ◽  
Soheila Khaghaninejad ◽  
Manizhe Mostofi
Keyword(s):  
Coumarin Derivatives ◽  
Pechmann Reaction

Experiments on the synthesis of some coumarin derivatives

1973 ◽  
Vol 26 (4) ◽  
pp. 899 ◽  
Author(s):  
ER Krajniak ◽  
E Ritchie ◽  
WC Taylor
Keyword(s):  
Acetic Acid ◽  
Sulphuric Acid ◽  
Fumaric Acid ◽  
Potassium Acetate ◽  
Coumarin Derivative ◽  
Oxidative Cyclization ◽  
Coumarin Derivatives ◽  
Pechmann Reaction

Evidence has been obtained that the reaction between a phenol and maleic or fumaric acid in the presence of sulphuric acid to yield a coumarin derivative, the Ponndorf reaction, is a variant of the Pechmann reaction. The scopes of the two reactions appear to be similar. ��� Attempts to effect the oxidative cyclization of hydroxyaryl cinnamates to 4-arylcoumarins, a key step in Seshadri's scheme for the biogenesis of neoflavanoids, were unsuccessful. 4-Aryl-3,4- dihydrocoumarins, which are readily available, are smoothly converted into 4-arylcoumarins by iodine and potassium acetate in acetic acid.

Pechmann Reaction in the Synthesis of Coumarin Derivatives

2014 ◽  
pp. 1-50 ◽  
Author(s):  
Majid M. Heravi ◽  
Soheila Khaghaninejad ◽  
Manizhe Mostofi
Keyword(s):  
Coumarin Derivatives ◽  
Pechmann Reaction

Coumarin derivatives from the roots of Heptaptera cilicica

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
Z Güvenalp ◽  
H Özbek ◽  
G Yılmaz ◽  
C Kazaz
Keyword(s):  
Coumarin Derivatives

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

A pilot web former designed to study retention-formation relationships

2010 ◽  
Vol 25 (2) ◽  
pp. 185-194
Author(s):  
Anna Svedberg ◽  
Tom Lindström
Keyword(s):  
Pilot Scale ◽  
Operating Conditions ◽  
Montmorillonite Clay ◽  
Speed Ratio ◽  
Good Reproducibility ◽  
Total Solids ◽  
Retention Aids ◽  
Solids Content ◽  
Relationship Of ◽  
The Relationship

Abstract A pilot-scale fourdrinier former has been developed for the purpose of investigating the relationship between retention and paper formation (features, retention aids, dosage points, etc.). The main objective of this publication was to present the R-F (Retention and formation)-machine and demonstrate some of its fields of applications. For a fine paper stock (90% hardwood and 10% softwood) with addition of 25% filler (based on total solids content), the relationship between retention and formation was investigated for a microparticulate retention aid (cationic polyacrylamide together with anionic montmorillonite clay). The retention-formation relationship of the retention aid system was investigated after choosing standardized machine operating conditions (e.g. the jet-to-wire speed ratio). As expected, the formation was impaired when the retention was increased. Since good reproducibility was attained, the R-F (Retention and formation)-machine was found to be a useful tool for studying the relationship between retention and paper formation.

Fluorescenсе Properties of Complexes of Coumarin Derivatives/CdTe Quantum Dots under Interaction with Ammonia Molecules in Microconcentrations

2016 ◽  
Vol 8 (4(1)) ◽  
pp. 04032-1-04032-5
Author(s):  
V. P. Mitsai ◽  
◽  
A. G. Misyura ◽  
S. V. Kryvets ◽  
Ya. P. Lazorenko ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cdte Quantum Dots ◽  
Coumarin Derivatives

Recent Advances in the Synthesis of Coumarin Derivatives via Pechmann Condensation

2016 ◽  
Vol 20 (7) ◽  
pp. 798-828 ◽  
Author(s):  
Abhay S. Zambare ◽  
Firoz A. Kalam Khan ◽  
Sureshchandra P. Zambare ◽  
Shantanu D. Shinde ◽  
Jaiprakash N. Sangshetti
Keyword(s):  
Coumarin Derivatives ◽  
Pechmann Condensation ◽  
Recent Advances

Synthesis of Coumarin Derivatives as Versatile Scaffolds for GSK-3β Enzyme Inhibition

2020 ◽  
Vol 20 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Carla S. Francisco ◽  
Clara L. Javarini ◽  
Iatahanderson de S. Barcelos ◽  
Pedro A.B. Morais ◽  
Heberth de Paula ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Glycogen Synthase ◽  
Synthetic Methods ◽  
Kinase Assay ◽  
Crystallographic Structure ◽  
Coumarin Derivatives ◽  
Enzymatic Production ◽  
Docking Simulations ◽  
In Silico Studies ◽  
Gsk 3Β

Background: Glycogen synthase kinase-3 (GSK-3) is involved in the phosphorylation and inactivation of glycogen synthase. GSK-3 inhibitors have been associated with a variety of diseases, including Alzheimer´s disease (AD), diabetes type II, neurologic disorders, and cancer. The inhibition of GSK-3β isoforms is likely to represent an effective strategy against AD. Objective: The present work aimed to design and synthesize coumarin derivatives to explore their potential as GSK-3β kinase inhibitors. Method: The through different synthetic methods were used to prepare coumarin derivatives. The GSK-3β activity was measured through the ADP-Glo™ Kinase Assay, which quantifies the kinasedependent enzymatic production of ADP from ATP, using a coupled-luminescence-based reaction. A docking study was performed by using the crystallographic structure of the staurosporine/GSK-3β complex [Protein Data Bank (PDB) code: 1Q3D]. Results: The eleven coumarin derivatives were obtained and evaluated as potential GSK-3β inhibitors. Additionally, in silico studies were performed. The results revealed that the compounds 5c, 5d, and 6b inhibited GSK-3β enzymatic activity by 38.97–49.62% at 1 mM. The other coumarin derivatives were tested at 1 mM, 1 µM, and 1 nM concentrations and were shown to be inhibitor candidates, with significant IC50 (1.224–6.875 µM) values, except for compound 7c (IC50 = 10.809 µM). Docking simulations showed polar interactions between compound 5b and Lys85 and Ser203, clarifying the mechanism of the most potent activity. Conclusion: The coumarin derivatives 3a and 5b, developed in this study, showed remarkable activity as GSK-3β inhibitors.

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