ChemInform Abstract: Estradiols Modified by Carbonylmetal Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor.

ChemInform ◽  
2010 ◽  
Vol 23 (39) ◽  
pp. no-no
Author(s):  
A. VESSIERES ◽  
S. TOP ◽  
C. VAILLANT ◽  
D. OSELLA ◽  
J.-P. MORNON ◽  
...  
Keyword(s):  
Receptor Proteins ◽  
Estradiol Receptor ◽  
Suicide Substrates

THE BIOSYNTHETIC SEQUENCE OF THE VARIOUS FORMS OF CYTOPLASMIC ESTRADIOL RECEPTOR

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S147
Author(s):  
P. I. Szendro ◽  
M. Little ◽  
P. W. Jungblut
Keyword(s):  
Estradiol Receptor

The extractability of estradiol receptor from unterine nuclei is independent of in-vivo exposure to estradiol

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S150-S151 ◽  
Author(s):  
P. W. JUNGBLUT ◽  
E. KALLWEIT ◽  
P. I. SZENDRO
Keyword(s):  
Estradiol Receptor

Destabilizing the Structural Integrity of SARS-CoV2 Receptor Proteins by Curcumin Along with Hydroxychloroquine: An Insilco Approach for a Combination Therapy

2020 ◽  
Author(s):  
Akhileshwar Srivastava ◽  
Divya Singh
Keyword(s):  
Binding Energy ◽  
Combination Therapy ◽  
Receptor Binding ◽  
Structural Integrity ◽  
Binding Domain ◽  
Receptor Binding Domain ◽  
Receptor Proteins ◽  
Main Protease ◽  
The Stability ◽  
Therapeutic Activities

Presently, an emerging disease (COVID-19) has been spreading across the world due to coronavirus (SARS-CoV2). For treatment of SARS-CoV2 infection, currently hydroxychloroquine has been suggested by researchers, but it has not been found enough effective against this virus. The present study based on in silico approaches was designed to enhance the therapeutic activities of hydroxychloroquine by using curcumin as an adjunct drug against SARS-CoV2 receptor proteins: main-protease and S1 receptor binding domain (RBD). The webserver (ANCHOR) showed the higher protein stability for both receptors with disordered score (<0.5). The molecular docking analysis revealed that the binding energy (-24.58 kcal/mol) of hydroxychloroquine was higher than curcumin (-20.47 kcal/mol) for receptor main-protease, whereas binding energy of curcumin (<a>-38.84</a> kcal/mol) had greater than hydroxychloroquine<a> (-35.87</a> kcal/mol) in case of S1 receptor binding domain. Therefore, this study suggested that the curcumin could be used as combination therapy along with hydroxychloroquine for disrupting the stability of SARS-CoV2 receptor proteins

scholarly journals Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin.

1994 ◽  
Vol 269 (32) ◽  
pp. 20629-20635 ◽  
Author(s):  
G.J. Fisher ◽  
H.S. Talwar ◽  
J.H. Xiao ◽  
S.C. Datta ◽  
A.P. Reddy ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Human Skin ◽  
Retinoid X Receptor ◽  
Receptor Proteins ◽  
Immunological Identification
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