ChemInform Abstract: Functionalized 2-Azabicyclo(3.3.1)nonanes. Part 17. Studies on the Synthesis of 8-Alkyl-8-aryl-2-azabicyclo(3.3.1)nonan-7-ones. A Short Synthetic Route to Functionalized 8-Alkyl Derivatives.

ChemInform ◽  
2010 ◽  
Vol 23 (32) ◽  
pp. no-no
Author(s):  
J. BONJOCH ◽  
N. CASAMITJANA ◽  
J. QUIRANTE ◽  
C. GARRIGA ◽  
J. BOSCH
Keyword(s):  
Synthetic Route ◽  
Alkyl Derivatives

A novel synthetic route to 2-alkylpropane-1,3-sultones and its application to the synthesis of 2-alkyl derivatives of tramiprosate

2007 ◽  
Vol 48 (49) ◽  
pp. 8587-8589 ◽  
Author(s):  
Benoit Bachand ◽  
Mohamed Atfani ◽  
Bita Samim ◽  
Sophie Lévesque ◽  
Daniel Simard ◽  
...  
Keyword(s):  
Synthetic Route ◽  
Alkyl Derivatives ◽  
Derivatives Of

scholarly journals New Syntheses and Ring Expansion Reactions of Cyclobutenimines

2010 ◽  
Vol 63 (12) ◽  
pp. 1656 ◽  
Author(s):  
Ernst Schaumann ◽  
Gerrit Oppermann ◽  
Michael Stranberg ◽  
Harold W. Moore
Keyword(s):  
Carbonyl Group ◽  
Ring Expansion ◽  
Synthetic Route ◽  
Tertiary Alcohols ◽  
Ring Enlargement ◽  
Alkyl Derivatives

Two routes are reported for the synthesis of iminocyclobutenones having N-(het)aryl substitution: an addition/substitution sequence starting with cyclobutenediones and an aza-Wittig method. A new synthetic route to N-alkyl derivatives is also presented. This involves O-alkylation of 3-alkylamino-1,2-cyclobutenediones using Meerwein’s reagent and subsequent deprotonation under non-hydrolytic conditions. Lithium organyls were found to add to the remaining carbonyl group. The resulting tertiary alcohols undergo ring enlargement on heating in xylene to give 4-aminophenols, 4-amino-1-naphthols, or cyclopenta-annulated quinolines from 4-vinyl, 4-aryl, and 4-alkynyl derivatives, respectively.

scholarly journals A Convenient Synthesis of (16S,20S)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its N-alkyl Derivatives

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2377
Author(s):  
Agnieszka Wojtkielewicz ◽  
Damian Pawelski ◽  
Przemysław Bazydło ◽  
Aneta Baj ◽  
Stanisław Witkowski ◽  
...  
Keyword(s):  
Ring Opening ◽  
Reductive Amination ◽  
Lactone Ring ◽  
Synthetic Route ◽  
Microwave Assisted ◽  
Alkyl Derivatives ◽  
Convenient Synthesis

A concise synthesis of (16S,20S)-3β-hydroxy-5α-pregnane-20,16-carbolactam from tigogenin via the corresponding lactone is described. The most efficient synthetic route consisted of the lactone ring-opening with aminoalane reagent followed by PDC or Dess-Martin oxidation. The oxo-amide obtained was subjected to cyclization with Et3SiH/TFA or Et3SiH/Bi(TfO)3. Alternately, the lactone was converted first to the oxo-acid, which was then subjected to the microwave-assisted reductive amination. N-Alkyl derivatives were also obtained in a similar way.

Studies on the synthesis of 8-alkyl-8-aryl-2-azabicyclo[3.3.1]nonan-7-ones. A short synthetic route to functionalized 8-alkyl derivatives

Tetrahedron ◽  
1992 ◽  
Vol 48 (15) ◽  
pp. 3131-3138 ◽  
Author(s):  
Josep Bonjoch ◽  
Núria Casamitjana ◽  
Josefina Quirante ◽  
Carmer Garriga ◽  
Joan Bosch
Keyword(s):  
Synthetic Route ◽  
Alkyl Derivatives

ChemInform Abstract: A Novel Synthetic Route to 2-Alkylpropane-1,3-sultones and Its Application to the Synthesis of 2-Alkyl Derivatives of Tramiprosate.

ChemInform ◽  
2008 ◽  
Vol 39 (12) ◽  
Author(s):  
Benoit Bachand ◽  
Mohamed Atfani ◽  
Bita Samim ◽  
Sophie Levesque ◽  
Daniel Simard ◽  
...  
Keyword(s):  
Synthetic Route ◽  
Alkyl Derivatives ◽  
Derivatives Of

A General Convergent Strategy for the Synthesis of Tetrasubstituted Furan Fatty Acids (FuFAs)

2019 ◽  
Author(s):  
Yamin Wang ◽  
Gareth Pritchard ◽  
Marc Kimber
Keyword(s):  
Fatty Acids ◽  
Spectral Data ◽  
Synthetic Route ◽  
Furan Fatty Acids

Synthetic route for the synthesis of tetrasubstituted furan fatty acids; including experimental details, characterisation, and spectral data of all intermediates.

Palladium-Catalyzed Asymmetric Annulation Between Aryl Iodides and Racemic Epoxides Using a Chiral Norbornene Cocatalyst

2018 ◽  
Author(s):  
Guangbin Dong ◽  
Renhe Li
Keyword(s):  
Isopropyl Ester ◽  
Synthetic Route ◽  
Initial Development ◽  
Aryl Iodides ◽  
Palladium Catalyzed

Herein, we describe our initial development of an asymmetric Pd-catalyzed annulation between aryl iodides and racemic epoxides for synthesis of 2,3-dihydrobenzofurans using a chiral norbornene cocatalyst. A series of enantiopure ester-, amide- and imide-substituted norbornenes have been prepared with a reliable synthetic route. Promising enantioselectivity (42-45% ee) has been observed using the isopropyl ester-substituted norbornene (N1*) and the amide-substituted norbornene (N7*).

Estimate of Hyperconjugation Strength in Alkylaromatics and Unsaturated Hydrocarbons Derived from Refractometric Data

2020 ◽  
Vol 23 (23) ◽  
pp. 2598-2613
Author(s):  
Boris A. Zaitsev
Keyword(s):  
Quantitative Estimation ◽  
Physical Phenomenon ◽  
Unsaturated Hydrocarbons ◽  
Resonance Effects ◽  
Alkyl Derivatives ◽  
Retrospective View ◽  
Scientific Papers ◽  
Polycyclic Aromatic ◽  
Qualitative Measure ◽  
Steric Inhibition Of Resonance

: A retrospective view of exaltation of refraction observed for many unsaturated and aromatic compounds demonstrates that this physical phenomenon is undeservedly considered only as a qualitative measure of conjugation. This mini-review discusses numerous papers by the author that have been published earlier in inaccessible periodicals and collections of scientific papers. Using a great number of illustrations, the author shows that this parameter can be successfully used for quantitative estimate of resonance effects in organic and polymer chemistry. The methods for derivation of strictly additive atomic and group refraction constants are described; these constants were subsequently used as a tool that allowed quantitative estimation of resonance effects in mono-, di-, tri- and polyalkylbenzenes, alkylnaphthalenes, some alkyl derivatives of unsaturated hydrocarbons. These effects cause strictly fixed increase in refraction of carbon atoms in different structural modifications (graphene, fullerene, diamond) and in polycyclic aromatic hydrocarbons. The relevant results regarding quantitative estimation of degree of steric inhibition of resonance in sterically hindered ortho-dialkylbenzenes, 1,2,3- trialkyl-, 1,2,3,4-tetraalkyl-, and 1,2,3,4,5-polyalkylbenzenes accumulated by the author are summarized.

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