ChemInform Abstract: Transfer of Divalent Metal Ions into the Organic Phase in the Systems Water-Chloroform-ZnCl2-CdCl2-HgCl2-NaOH-(NaCl)-n-Alkyltetra(oxyethylene)carboxylic Acid.

ChemInform ◽  
1990 ◽  
Vol 21 (43) ◽  
Author(s):  
J. STRZELBICKI ◽  
B. STRZELBICKA ◽  
J. BEGER ◽  
L. HINZ
Keyword(s):  
Carboxylic Acid ◽  
Metal Ions ◽  
Organic Phase ◽  
Divalent Metal ◽  
Divalent Metal Ions

Transfer of divalent metal ions into the organic phase of the systems water–chloroform–ZnCl2–CdCl2–HgCl2–NaOH–(NaCl)–n-alkyltri(oxyethylene)carboxylic acid

1988 ◽  
Vol 66 (10) ◽  
pp. 2640-2646 ◽  
Author(s):  
Jerzy Strzelbicki ◽  
Witold Charewicz ◽  
Jorg Beger ◽  
Lutz Hinz
Keyword(s):  
Carboxylic Acid ◽  
Aqueous Solutions ◽  
Metal Ions ◽  
Organic Phase ◽  
Metal Ion ◽  
Alkyl Chain ◽  
Divalent Metal ◽  
Divalent Metal Ions ◽  
Chemical Equilibria ◽  
Divalent Metal Ion

The influence of the length of an n-alkyl chain incorporated into the molecule of an n-alkyltri(oxyethylene) carboxylic acid of a general formula CnH(2n+1)(OCH2CH2)3OCH2CO2H(n = 6, 8, 10, and 12, respectively) on transfer of the zinc group element ions into chloroform was investigated. Metal ions were transferred from the aqueous solutions of ZnCl2, CdCl2, and HgCl2 at initial concentrations of 0.835 mM and 1.67 mM with, and without, added NaCl. From the aqueous solutions to which no NaCl was added, the selectivity of transfer of divalent metal ions into the organic phase was low.The selectivity of transfer of the divalent metal ions improved remarkably when NaCl was added to the aqueous phase due to the chemical equilibria involving complexation of the divalent metal ions by Cl−, OH−, and n-alkyltri(oxyethylene) carboxylic acid. In most systems (with NaCl added), Zn(II) was separated from Cd(II) and Hg(II). Less lipophilic n-alkyltri(oxyethylene) carboxylic acids (with a shorter n-alkyl chain incorporated) exhibited higher selectivity and efficiency as divalent metal ion carriers.

scholarly journals Structural and Binding Analysis of Pyrimidinol Carboxylic Acid andN-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

2011 ◽  
Vol 55 (6) ◽  
pp. 2905-2915 ◽  
Author(s):  
Eric B. Lansdon ◽  
Qi Liu ◽  
Stephanie A. Leavitt ◽  
Mini Balakrishnan ◽  
Jason K. Perry ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Metal Ions ◽  
Active Site ◽  
Water Environment ◽  
Divalent Metal ◽  
Rnase H ◽  
Accurate Assessment ◽  
Divalent Metal Ions ◽  
Substrate State ◽  
Hiv 1

ABSTRACTHIV-1 RNase H breaks down the intermediate RNA-DNA hybrids during reverse transcription, requiring two divalent metal ions for activity. Pyrimidinol carboxylic acid andN-hydroxy quinazolinedione inhibitors were designed to coordinate the two metal ions in the active site of RNase H. High-resolution (1.4 Å to 2.1 Å) crystal structures were determined with the isolated RNase H domain and reverse transcriptase (RT), which permit accurate assessment of the metal and water environment at the active site. The geometry of the metal coordination suggests that the inhibitors mimic a substrate state prior to phosphodiester catalysis. Surface plasmon resonance studies confirm metal-dependent binding to RNase H and demonstrate that the inhibitors do not bind at the polymerase active site of RT. Additional evaluation of the RNase H site reveals an open protein surface with few additional interactions to optimize active-site inhibitors.

Stability constants and spectral studies of complexes of 2-hydroxy-5-methylazobenzene-2′-carboxylic acid with some divalent metal ions

1984 ◽  
Vol 62 (11) ◽  
pp. 2299-2301
Author(s):  
C. Mahalingam ◽  
J. K. Sthapak ◽  
D. D. Sharma ◽  
R. L. Tiwari ◽  
Smita Sthapak
Keyword(s):  
Carboxylic Acid ◽  
Metal Ions ◽  
Metal Complexes ◽  
Stability Constants ◽  
Divalent Metal ◽  
Reflectance Spectra ◽  
Spectral Studies ◽  
Divalent Metal Ions ◽  
The Stability

The stability constants of metal complexes of 2-hydroxy-5-methylazobenzene-2′-carboxylic acid have been determined spectrophotometrically. These follow the Irving–Williams sequence: log KOH(H) = 10.67, log K1(Co) = 9.02, log K1(Ni) = 9.68, log K1(Cu) = 13.37, log K1(Zn) = 7.58, and [Formula: see text]The chelates of Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), and [Formula: see text] with the dye have been prepared and characterized on the basis of their ir and reflectance spectra.

Thermal properties and spectroscopic characteristics of the complexes of pyrazine-2-carboxylic acid with divalent metal ions

1980 ◽  
Vol 38 (2) ◽  
pp. 225-233 ◽  
Author(s):  
A.L. Magri ◽  
A.D. Magri ◽  
F. Balestrieri ◽  
E. Cardarelli ◽  
G. D'Ascenzo ◽  
...  
Keyword(s):  
Thermal Properties ◽  
Carboxylic Acid ◽  
Metal Ions ◽  
Divalent Metal ◽  
Divalent Metal Ions ◽  
Spectroscopic Characteristics

Interaction of divalent metal ions with the NADP+-malic enzyme from maize leaves

1991 ◽  
Vol 81 (4) ◽  
pp. 462-466 ◽  
Author(s):  
Maria Fabiana Drincovich ◽  
Alberto A. Iglesias ◽  
Carlos S. Andreo
Keyword(s):  
Metal Ions ◽  
Malic Enzyme ◽  
Divalent Metal ◽  
Divalent Metal Ions ◽  
Maize Leaves

scholarly journals Regulation of divalent metal ions to the aggregation and membrane damage of human islet amyloid polypeptide oligomers

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12815-12825
Author(s):  
Yajie Wang ◽  
Feihong Meng ◽  
Tong Lu ◽  
Chunyun Wang ◽  
Fei Li
Keyword(s):  
Metal Ions ◽  
Metal Binding ◽  
Membrane Damage ◽  
Islet Amyloid Polypeptide ◽  
Divalent Metal ◽  
Human Islet ◽  
Divalent Metal Ions ◽  
Islet Amyloid ◽  
Induced Membrane ◽  
Human Islet Amyloid Polypeptide

Their is a counteraction between a decrease in the disruptive ability of metal-associated oligomer species and an increase in the quantity of oligomers promoted by the metal binding in the activity of hIAPP induced membrane damage.

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