ChemInform Abstract: Catalytic Reaction of Mono-Substituted Furazans with Methyl Diazoacetate.

ChemInform ◽  
1990 ◽  
Vol 21 (29) ◽  
Author(s):  
A. E. VASIL'VITSKII ◽  
A. B. SHEREMETEV ◽  
T. S. NOVIKOVA ◽  
L. I. KHMEL'NITSKII ◽  
O. M. NEFEDOV
Keyword(s):  
Catalytic Reaction ◽  
Methyl Diazoacetate

ChemInform Abstract: Catalytic Reaction of Methyl Diazoacetate with 1-Methyl-2-alkenylpyrroles.

ChemInform ◽  
1989 ◽  
Vol 20 (39) ◽  
Author(s):  
V. M. SHOSTAKOVSKII ◽  
A. U. MUSAEV ◽  
A. E. VASIL'VITSKII ◽  
A. M. GULIEV ◽  
O. M. NEFEDOV
Keyword(s):  
Catalytic Reaction ◽  
Methyl Diazoacetate

Catalytic reaction of methyl diazoacetate with 1-methyl-2-alkenylpyrroles

1989 ◽  
Vol 38 (3) ◽  
pp. 641-645 ◽  
Author(s):  
V. M. Shostakovskii ◽  
A. U. Musaev ◽  
A. E. Vasil'vitskii ◽  
A. M. Guliev ◽  
O. M. Nefedov
Keyword(s):  
Catalytic Reaction ◽  
Methyl Diazoacetate

Catalytic reaction of methyl diazoacetate with silylated enynes

1993 ◽  
Vol 42 (7) ◽  
pp. 1191-1195
Author(s):  
E. A. Shapiro ◽  
A. V. Kalinin ◽  
D. N. Platonov ◽  
O. M. Nefedov
Keyword(s):  
Catalytic Reaction ◽  
Methyl Diazoacetate

ChemInform Abstract: Catalytic Reaction of Methyl Diazoacetate (II) with Silylated Enynes ( I).

ChemInform ◽  
2010 ◽  
Vol 25 (31) ◽  
pp. no-no
Author(s):  
E. A. SHAPIRO ◽  
A. V. KALININ ◽  
D. N. PLATONOV ◽  
O. M. NEFEDOV
Keyword(s):  
Catalytic Reaction ◽  
Methyl Diazoacetate

Catalytic reaction of monosubstituted furazanes with methyl diazoacetate

1989 ◽  
Vol 38 (12) ◽  
pp. 2640-2640 ◽  
Author(s):  
A. E. Vasil'vitskii ◽  
A. B. Sheremetev ◽  
T. S. Novikova ◽  
L. I. Khmel'nitskii ◽  
O. M. Nefedov
Keyword(s):  
Catalytic Reaction ◽  
Methyl Diazoacetate

Catalytic reaction of 1-chloropropenyl butyl ethers with methyl diazoacetate

2012 ◽  
Vol 82 (4) ◽  
pp. 663-667
Author(s):  
L. N. Ivanova ◽  
R. M. Sultanova ◽  
S. S. Zlotsky ◽  
V. A. Dokichev
Keyword(s):  
Catalytic Reaction ◽  
Methyl Diazoacetate

Protein Flexibility Catalyzes a Cell Signaling Reaction of the Ras-GAP Complex

2019 ◽  
Author(s):  
Keiei Kumon ◽  
Masahiro Higashi ◽  
Shinji Saito ◽  
Shigehiko Hayashi
Keyword(s):  
Cell Signaling ◽  
Conformational Changes ◽  
Catalytic Reaction ◽  
Protein Complex ◽  
Enzyme Mechanism ◽  
Activation Free Energy ◽  
Chemical Catalysis ◽  
Simple Chemical ◽  
A Cell ◽  
Enzyme Molecules

Many enzyme molecules exhibit characteristic global and slow dynamics which furnish them with allostery realizing remarkable molecular functionalities more than simple chemical catalysis. However, molecular mechanism of a catalytic reaction associated with the molecular flexibility of enzymes is not well-understood. Here we report a hybrid molecular simulation study on GTPase activity of a Ras-GAP protein complex for cell signaling termination. We unveiled that extensive conformational changes of the protein complex and exclusion of internal water molecules are induced upon the transition state (TS) formation in the catalytic reaction and significantly lower the reaction activation free energy. We also revealed that tumor-related mutations perturb those conformational changes upon the TS formation, leading to reduction of the catalytic activity. The findings of the remarkably dynamic protein conformation directly linking to the catalytic reaction have broad implications for understanding of enzyme mechanism and for developments of allosteric drugs and novel catalysts.

ChemInform Abstract: Catalytic Reaction of Dimethyl Diazomalonate with 2-Mono- and 2,5-Dialkyl(alkenyl)-Substituted Furans.

ChemInform ◽  
1989 ◽  
Vol 20 (22) ◽  
Author(s):  
O. M. NEFEDOV ◽  
A. E. VASIL'VITSKII ◽  
V. L. ZLATKINA ◽  
D. S. YUFIT ◽  
YU. T. STRUCHKOV ◽  
...  
Keyword(s):  
Catalytic Reaction ◽  
Substituted Furans
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