ChemInform Abstract: Phosphaalkynes: New Building Blocks in Synthetic Chemistry

ChemInform ◽  
1990 ◽  
Vol 21 (25) ◽  
Author(s):  
M. REGITZ
Keyword(s):  
Building Blocks ◽  
Synthetic Chemistry

Enantioselective Intermolecular Murai-Type Alkene Hydroarylation Reactions

Synthesis ◽  
2021 ◽  
Author(s):  
John F. Bower ◽  
Timothy P. Aldhous ◽  
Raymond W. M. Chung ◽  
Andrew G. Dalling
Keyword(s):  
Building Blocks ◽  
Short Review ◽  
Synthetic Chemistry ◽  
Complex Building

AbstractStrategies that enable the efficient assembly of complex building blocks from feedstock chemicals are of paramount importance to synthetic chemistry. Building upon the pioneering work of Murai and co-workers in 1993, C–H-activation-based enantioselective hydroarylations of alkenes offer a particularly promising framework for the step- and atom-economical installation of benzylic stereocenters. This short review presents recent intermolecular enantioselective Murai-type alkene hydroarylation methodologies and the mechanisms by which they proceed.1 Introduction2 Enantioselective Hydroarylation Reactions of Strained Bicyclic Alkenes3 Enantioselective Hydroarylation Reactions of Electron-Rich Acyclic Alkenes4 Enantioselective Hydroarylation Reactions of Electron-Poor Acyclic Alkenes5 Enantioselective Hydroarylation Reactions of Minimally Polarized Acyclic Alkenes6 Conclusion and Outlook

scholarly journals The Origin of Life on Earth and the Design of Alternative Life Forms

2017 ◽  
Vol 01 (02) ◽  
pp. 121-131 ◽  
Author(s):  
Jack W. Szostak
Keyword(s):  
Nucleic Acids ◽  
Origin Of Life ◽  
Artificial Life ◽  
Building Blocks ◽  
Life Forms ◽  
Chemical Energy ◽  
Synthetic Chemistry ◽  
Broad Scope ◽  
The Origin Of Life ◽  
Life On Earth

To understand the origin of life on Earth, and to evaluate the potential for life on exoplanets, we must understand the pathways that lead from chemistry to biology. Recent experiments suggest that a chemically rich environment that provides the building blocks of membranes, nucleic acids and peptides, along with sources of chemical energy, could result in the emergence of replicating, evolving cells. The broad scope of synthetic chemistry suggests that it may be possible to design and construct artificial life forms based upon a very different biochemistry than that of existing biology.

scholarly journals Formal Electrophilic Phenylation Reaction with Tropylium Ion

2021 ◽  
Author(s):  
Demelza Lyons ◽  
An Huy Dinh ◽  
Reece Crocker ◽  
Binh Khanh Mai ◽  
Thanh Vinh Nguyen
Keyword(s):  
Reactive Intermediates ◽  
Building Blocks ◽  
Synthetic Chemistry ◽  
Coupling Reactions ◽  
Ring Contraction ◽  
Aryl Radicals ◽  
Biaryl Coupling ◽  
New Strategy

Arylation reaction is an important transformation in synthetic chemistry as aryl building blocks are ubiquitous in valuable organic frameworks. Traditionally, this type of reaction has been carried out either via biaryl coupling reactions or with the use of reactive intermediates such as arynes or aryl radicals. Direct electrophilic arylation reactions have been rarely reported in literature, as the required arenium building blocks are often unstable or inaccessible. To develop a new strategy for such transformation, we herein introduce the development of a formal phenylation reaction, which proceeds via an electrophilic cycloheptatrienylation with tropylium ion, followed by an oxidative ring-contraction.

scholarly journals Coding Synthetic Chemistry Strategies into Bacterial Designer Cells

2021 ◽  
Author(s):  
Yu-Chang Liu ◽  
Zhong-Liu Wu ◽  
Jan Deska
Keyword(s):  
Building Blocks ◽  
Cell System ◽  
Synthetic Chemistry ◽  
Bacterial Host ◽  
Whole Cell ◽  
Isolation And Purification ◽  
Platform Chemicals ◽  
Natural Enzyme ◽  
High Degree

<p>Following a synthetic chemistry blueprint for the valorization of lignocellulosic platform chemicals, this study showcases a so far unprecedented approach to implement non-natural enzyme modules in vivo. For the design of a novel functional whole cell tool, two purely abiotic transformations were incorporated into a recombinant bacterial host that allows production of complex lactone building blocks. This whole cell system streamlines the synthetic cascade, eliminates isolation and purification steps, and provides a high degree stereoselectivity that has so far been elusive in the chemical methodology.</p>

scholarly journals Coding Synthetic Chemistry Strategies into Bacterial Designer Cells

2021 ◽  
Author(s):  
Yu-Chang Liu ◽  
Zhong-Liu Wu ◽  
Jan Deska
Keyword(s):  
Building Blocks ◽  
Cell System ◽  
Synthetic Chemistry ◽  
Bacterial Host ◽  
Whole Cell ◽  
Isolation And Purification ◽  
Platform Chemicals ◽  
Natural Enzyme ◽  
High Degree

<p>Following a synthetic chemistry blueprint for the valorization of lignocellulosic platform chemicals, this study showcases a so far unprecedented approach to implement non-natural enzyme modules in vivo. For the design of a novel functional whole cell tool, two purely abiotic transformations were incorporated into a recombinant bacterial host that allows production of complex lactone building blocks. This whole cell system streamlines the synthetic cascade, eliminates isolation and purification steps, and provides a high degree stereoselectivity that has so far been elusive in the chemical methodology.</p>

scholarly journals α-Functionalization of Imines via Visible Light Photoredox Catalysis

Catalysts ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 562 ◽  
Author(s):  
Alberto F. Garrido-Castro ◽  
M. Carmen Maestro ◽  
José Alemán
Keyword(s):  
Visible Light ◽  
Building Blocks ◽  
Single Electron ◽  
Synthetic Chemistry ◽  
Photoredox Catalysis ◽  
Reaction Conditions ◽  
Radical Intermediates ◽  
Research Programs ◽  
Electron Reduction

The innate electrophilicity of imine building blocks has been exploited in organic synthetic chemistry for decades. Inspired by the resurgence in photocatalysis, imine reactivity has now been redesigned through the generation of unconventional and versatile radical intermediates under mild reaction conditions. While novel photocatalytic approaches have broadened the range and applicability of conventional radical additions to imine acceptors, the possibility to use these imines as latent nucleophiles via single-electron reduction has also been uncovered. Thus, multiple research programs have converged on this issue, delivering creative and practical strategies to achieve racemic and asymmetric α-functionalizations of imines under visible light photoredox catalysis.

scholarly journals Formal Electrophilic Phenylation Reaction with Tropylium Ion

2021 ◽  
Author(s):  
Demelza Lyons ◽  
An Huy Dinh ◽  
Reece Crocker ◽  
Binh Khanh Mai ◽  
Thanh Vinh Nguyen
Keyword(s):  
Reactive Intermediates ◽  
Building Blocks ◽  
Synthetic Chemistry ◽  
Coupling Reactions ◽  
Ring Contraction ◽  
Aryl Radicals ◽  
Biaryl Coupling ◽  
New Strategy

Arylation reaction is an important transformation in synthetic chemistry as aryl building blocks are ubiquitous in valuable organic frameworks. Traditionally, this type of reaction has been carried out either via biaryl coupling reactions or with the use of reactive intermediates such as arynes or aryl radicals. Direct electrophilic arylation reactions have been rarely reported in literature, as the required arenium building blocks are often unstable or inaccessible. To develop a new strategy for such transformation, we herein introduce the development of a formal phenylation reaction, which proceeds via an electrophilic cycloheptatrienylation with tropylium ion, followed by an oxidative ring-contraction.

scholarly journals Cyclic Hypervalent Iodine Reagents for Azidation: Safer Reagents and Photoredox Catalyzed Ring Expansion

2018 ◽  
Author(s):  
Sebastien Alazet ◽  
Johannes preindl ◽  
raphael simonet davin ◽  
Stefano Nicolai ◽  
Annik Nanchen ◽  
...  
Keyword(s):  
Safety Profile ◽  
Chemical Biology ◽  
Materials Science ◽  
Building Blocks ◽  
Ring Expansion ◽  
Hypervalent Iodine ◽  
Synthetic Chemistry ◽  
Safety Study

Azides are building blocks of increasing importance in synthetic chemistry, chemical biology and materials science. Azidobenziodoxolone (ABX, Zhdankin reagent) is a valuable azide source, but its safety profile has not been thoroughly established. Herein, we report a safety study of ABX, which shows its highly hazardous nature. We further introduce and study two derivatives, <i>t</i>Bu-ABX and ABZ (azidobenziodazolone). ABZ displayed a similar reactivity but a better safety profile than ABX, and could be used in established photoredox- and metal-mediated azidation processes, as well as in a new ring-expansion of silylated cyclobutanols to give azidated cyclopentanones.

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