ChemInform Abstract: Reaction of 3-Nitro- and 3,5-Dinitro-2-pyridones with Hydrazine Hydrate.

Aims: In this article we have developed an eco-friendly one-pot multi-component reaction methodology was employed for the green synthesis of functionalized pyrazole derivatives viz cyclo-condensation of aromatic aldehydes, ethyl acetoacetate and phenyl hydrazine and/or hydrazine hydrate in the presence of cetyltrimethylammoniumbromide (CTAB) at 90°C temperature in aqueous medium. Method: In the present protocol we developed a green method for the synthesis of functionalized pyrazole derivatives through one-pot, multi-component cyclo-condensation of aromatic aldehydes, phenyl hydrazine or hydrazine hydrate and ethyl acetoacetate using cetyltrimethylammoniumbromide (CTAB) as a catalyst in water as solvent. Our methodology confers advantages such as short reaction time, atom economy, purification of product without using column chromatographic and hazardous solvent. The reaction is being catalyzed by cetyltrimethylammoniumbromide (CTAB) and thus products are formed under the green reaction conditions. Results: Initially the reaction of benzaldehyde and phenylhydrazine with ethyl acetoacetate was carried out in water at room temperature in the absence of the catalyst; no product was obtained after 24 h (Table 1 entry 1). When the reaction was carried out using L-proline as catalyst in ethanol at 70°C the yield of product was 20. Conclusion: This research not only provides a green and efficient method for the synthesis of sulfinic esters but also shows new applications of electrochemistry in organic synthesis. We consider that this green and efficient synthetic protocol used to prepare sulfinic esters will have good applications in future. In conclusion, we have developed successfully a green and efficient one-pot multi-component methodology for the synthesis of substituted pyrazoles using CTAB as a catalyst in water as solvent with excellent yields. Purifications of compounds were achieved without the use of traditional chromatographic procedures. This methodology has advantages of operational simplicity, clean reaction profiles and relatively broad scope which make it more attractive for the diversity oriented synthesis of these heterocyclic libraries. In this methodology we suggest the further alternative possibility for formation of substituted pyrazoles. The compound 7h can be used as an anticancer drug in pharma industry.

Download Full-text

Crystalline borophene quantum dots and their derivative boron nanospheres

Materials Advances ◽

10.1039/d1ma00124h ◽

2021 ◽

Author(s):

Huiqi Wang ◽

Duo An ◽

Mei Wang ◽

Liwen Sun ◽

Ying Li ◽

...

Keyword(s):

Quantum Dots ◽

Hydrazine Hydrate ◽

High Power ◽

Photoluminescence Properties ◽

Chemical Exfoliation ◽

One Step

Crystalline borophene quantum dots with two-photo fluorescence and their derivative boron nanospheres with hydrazine hydrate-dependent photoluminescence properties were prepared by efficient high-power sonication method combined with chemical exfoliation and one-step...

Download Full-text

Formation and optical properties of silver superlattice using hydrazine hydrate as reducing agent

Microsystem Technologies ◽

10.1007/s00542-011-1308-9 ◽

2011 ◽

Vol 17 (8) ◽

pp. 1293-1299 ◽

Cited By ~ 4

Author(s):

Danhui Zhang ◽

Xiaoheng Liu ◽

Xin Wang

Keyword(s):

Optical Properties ◽

Hydrazine Hydrate ◽

Reducing Agent

Download Full-text

ChemInform Abstract: Formation of Pyrazoles and Thieno(3,2-c)pyrazoles on Reaction of 3- Hydroxy- or 3-Methoxy-2-oxothiophenes with Hydrazine Hydrate Under Wolff-Kishner Conditions.

ChemInform ◽

10.1002/chin.199152173 ◽

2010 ◽

Vol 22 (52) ◽

pp. no-no

Author(s):

J. M. BARKER ◽

P. R. HUDDLESTON ◽

G. D. KHANDELWAL ◽

M. L. WOOD

Keyword(s):

Hydrazine Hydrate

Download Full-text

Structural changes in polyacrylonitrile fibre modified with hydrazine hydrate

Fibre Chemistry ◽

10.1007/bf00548888 ◽

1973 ◽

Vol 4 (5) ◽

pp. 533-535 ◽

Cited By ~ 1

Author(s):

I. F. Khudoshev ◽

G. D. Litovchenko

Keyword(s):

Hydrazine Hydrate ◽

Structural Changes ◽

Polyacrylonitrile Fibre

Download Full-text

X-Ray Photoelectron Spectroscopy Study on Reduction of Graphene Oxide with Hydrazine Hydrate

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.287-290.539 ◽

2011 ◽

Vol 287-290 ◽

pp. 539-543 ◽

Cited By ~ 5

Author(s):

Wen Shi Ma ◽

Jun Wen Zhou ◽

Xiao Dan Lin

Keyword(s):

Graphene Oxide ◽

Hydrazine Hydrate ◽

Photoelectron Spectroscopy ◽

Reduction Rate ◽

Reduction Reaction ◽

Chemical Compositions ◽

Total Oxygen ◽

Graphene Oxides ◽

X Ray ◽

Oxygen Groups

Graphene oxide was prepared through Hummers' method，then different reduced graphenes were prepared via reduction of graphene oxide with hydrazine hydrate for 1h、12h and 24h. X-ray photoelectron spectroscopy (XPS) was used for the characterization of graphene oxide and the reduced graphenes. The variation of the contents of carbon in carbon and oxygen functional groups and chemical compositions of graphene oxides were investigated through analysis the content of different carbon atoms in different reduced graphenes. The results showed that the reduction reaction was very fast in the first 1 h, the content of total oxygen bonded carbon atoms decreased from 83.6% to 22.1%, and then after the reduction rate became very slow. After 12h, the content of total oxygen bonded carbon atom is 19.56%, only 2.54% lower than that of 1h’s. At the same time, C-N was introduced in the graphene oxides; this increased the stereo-hindrance for hydrazine hydrate attacking the C-Oxygen groups, thus reduced the reduction rate. After reduction for 24h, there still exists 16.4% oxygen bonded carbon atoms and the total conversion ratio of graphene approaches 70%.

Download Full-text