ChemInform Abstract: Asymmetric Conjugate Addition of Organometallic Reagents in the Presence of Tertiary Amines to Chiral α,β-Unsaturated Amido Carboxylic Acids.

1986 ◽  
Vol 17 (36) ◽  
Author(s):  
K. SOAI ◽  
A. OOKAWA
Keyword(s):  
Carboxylic Acids ◽  
Conjugate Addition ◽  
Tertiary Amines ◽  
Organometallic Reagents

Conjugate Addition of RMgX–3MeLi to α,β-Unsaturated Amides and α,β-Unsaturated Carboxylic Acids

2007 ◽  
Vol 36 (6) ◽  
pp. 736-737 ◽  
Author(s):  
Mikiko Kikuchi ◽  
Satomi Niikura ◽  
Nao Chiba ◽  
Nahoko Terauchi ◽  
Morio Asaoka
Keyword(s):  
Carboxylic Acids ◽  
Conjugate Addition ◽  
Unsaturated Carboxylic Acids

scholarly journals Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides

ACS Omega ◽  
2021 ◽  
Author(s):  
Xu Zhang ◽  
Yu-Mei Huang ◽  
Hua-Li Qin ◽  
Zhang Baoguo ◽  
K. P. Rakesh ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Conjugate Addition

Conjugate Addition of RMgX—3MeLi to α,β-Unsaturated Amides and α,β-Unsaturated Carboxylic Acids.

ChemInform ◽  
2007 ◽  
Vol 38 (45) ◽  
Author(s):  
Mikiko Kikuchi ◽  
Satomi Niikura ◽  
Nao Chiba ◽  
Nahoko Terauchi ◽  
Morio Asaoka
Keyword(s):  
Carboxylic Acids ◽  
Conjugate Addition ◽  
Unsaturated Carboxylic Acids

Cationic Pd(II)/bipyridine-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated carboxylic acids in aqueous media

2018 ◽  
Vol 59 (13) ◽  
pp. 1192-1195 ◽  
Author(s):  
Yuxin Ni ◽  
Kaixuan Song ◽  
Kai Shen ◽  
Zhenyu Yang ◽  
Rui Liu ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Aqueous Media ◽  
Conjugate Addition ◽  
Arylboronic Acids ◽  
Unsaturated Carboxylic Acids

scholarly journals Copper-catalyzed enantioselective conjugate addition of organometallic reagents to challenging Michael acceptors

2020 ◽  
Vol 16 ◽  
pp. 212-232 ◽  
Author(s):  
Delphine Pichon ◽  
Jennifer Morvan ◽  
Christophe Crévisy ◽  
Marc Mauduit
Keyword(s):  
Natural Products ◽  
Conjugate Addition ◽  
Catalytic Transformation ◽  
Chiral Molecules ◽  
Catalytic Systems ◽  
Organometallic Reagents ◽  
Recent Advances ◽  
Wide Range ◽  
Michael Acceptors

The copper-catalyzed enantioselective conjugate addition (ECA) of organometallic nucleophiles to electron-deficient alkenes (Michael acceptors) represents an efficient and attractive methodology for providing a wide range of relevant chiral molecules. In order to increase the attractiveness of this useful catalytic transformation, some Michael acceptors bearing challenging electron-deficient functions (i.e., aldehydes, thioesters, acylimidazoles, N-acyloxazolidinones, N-acylpyrrolidinones, amides, N-acylpyrroles) were recently investigated. Remarkably, only a few chiral copper-based catalytic systems have successfully achieved the conjugate addition of different organometallic reagents to these challenging Michael acceptors, with excellent regio- and enantioselectivity. Furthermore, thanks to their easy derivatization, the resulting chiral conjugated products could be converted into various natural products. The aim of this tutorial review is to summarize recent advances accomplished in this stimulating field.

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