ChemInform Abstract: A Conceptually Different Approach to the Asymmetric Synthesis of α-Substituted Carbonyl Compounds.

1986 ◽  
Vol 17 (25) ◽  
Author(s):  
K. MARUOKA ◽  
S. NAKAI ◽  
M. SAKURAI ◽  
H. YAMAMOTO
Keyword(s):  
Asymmetric Synthesis ◽  
Carbonyl Compounds

Enantioselective Radical Functionalization of Imines and Iminium Intermediates via Visible Light Photoredox Catalysis

Synthesis ◽  
2020 ◽  
Author(s):  
Jia-Jia Zhao ◽  
Hong-Hao Zhang ◽  
Shouyun Yu
Keyword(s):  
Visible Light ◽  
Asymmetric Synthesis ◽  
Carbonyl Compounds ◽  
Asymmetric Reduction ◽  
Chemical Transformations ◽  
Photoredox Catalysis ◽  
Radical Coupling ◽  
Mild Conditions ◽  
Iminium Ions ◽  
Radical Functionalization

Visible light photoredox catalysis has recently emerged as a powerful tool for the development of new and valuable chemical transformations under mild conditions. Visible-light promoted enantioselective radical transformations of imines and iminium intermediates provide new opportunities for the asymmetric synthesis of amines and asymmetric β-functionalization of unsaturated carbonyl compounds. In this review, the advance in the catalytic asymmetric radical functionalization of imines, as well as iminium intermediates, are summarized. 1 Introduction 2 The enantioselective radical functionalization of imines 2.1 Asymmetric reduction 2.2 Asymmetric cyclization 2.3 Asymmetric addition 2.4 Asymmetric radical coupling 3 The enantioselective radical functionalization of iminium ions 3.1 Asymmetric radical alkylation 3.2 Asymmetric radical acylation 4 Conclusion

Bifunctional Squaramide Catalyzed Asymmetric Synthesis of Chiral α-Mercaptosilanes

2021 ◽  
Author(s):  
Ye Zhang ◽  
Jingcheng Guo ◽  
Jinna Han ◽  
Xiangui Zhou ◽  
Wei Cao ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Carbonyl Compounds ◽  
Nucleophilic Addition

Bifunctional squaramide-catalyzed nucleophilic addition of thiophenols to easily available β-silyl α,β-unsaturated carbonyl compounds has been successfully developed. A structurally diverse set of chiral α-mercaptosilanes was efficiently prepared in good to...

scholarly journals Asymmetric synthesis with "privileged" ligands

2001 ◽  
Vol 73 (2) ◽  
pp. 325-329 ◽  
Author(s):  
Marco Bandini ◽  
Pier Giorgio Cozzi ◽  
Achille Umani-Ronchi
Keyword(s):  
Open Access ◽  
Asymmetric Synthesis ◽  
Carbonyl Compounds ◽  
Aromatic Aldehydes ◽  
Redox Processes ◽  
Asymmetric Allylation ◽  
Salen Complexes ◽  
Allyl Halides ◽  
Different Types ◽  
Enantioselective Addition

Different types of chiral "privileged" ligands 1 and 2 in promoting enantioselective addition of allylating agents to aliphatic and aromatic aldehydes are described. Here, a new concept in the asymmetric allylation reaction is presented. Redox [Cr (Salen) ] mediated addition of allyl halides to carbonyl compounds is described, and mechanistic investigations are discussed. These results open access to the fascinating area of the catalytic redox processes mediated by metallo-Salen complexes.

Asymmetric Synthesis of Ethers by Catalytic Alkene Hydro­alkoxy­lation

Synthesis ◽  
2020 ◽  
Vol 52 (15) ◽  
pp. 2127-2146
Author(s):  
Zhi Li ◽  
Wen-Bin Xie
Keyword(s):  
Asymmetric Synthesis ◽  
Carboxylic Acids ◽  
Carbonyl Compounds ◽  
High Reactivity ◽  
Enol Ethers ◽  
Unsaturated Esters ◽  
Unsaturated Ketones ◽  
Recent Developments ◽  
Catalytic Asymmetric

Many chiral ethers have important physiological activities. Although many asymmetric hydroalkoxylations of olefins with alcohols or phenols have been developed to make chiral ethers, challenges still remain in achieving high reactivity and selectivity over an ever-increasing diversity of alkenes and alcohols. In this review, recent developments on catalytic asymmetric alkene hydroalkoxylations are summarized based on the substitution patterns of alkenes.1 Introduction2 Asymmetric Hydroalkoxylation of Non-Activated Alkenes2.1 Intramolecular Additions2.2 Intermolecular Additions3 Asymmetric Hydroalkoxylation of Enol Ethers3.1 Intramolecular Additions3.2 Intermolecular Additions4 Asymmetric Hydroalkoxylation of α,β-Unsaturated Carbonyl Compounds4.1 α,β-Unsaturated Ketones and Aldehydes as Substrates4.2 α,β-Unsaturated Esters, Amides and Carboxylic Acids as Substrates5 Asymmetric Hydroalkoxylation of Allenes5.1 Intramolecular Additions5.2 Intermolecular Additions6 Conclusion

A Conceptually Different Approach to the Asymmetric Synthesis of α-Substituted Carbonyl Compounds

Synthesis ◽  
1986 ◽  
Vol 1986 (02) ◽  
pp. 130-132 ◽  
Author(s):  
Keiji Maruoka ◽  
Shuichi Nakai ◽  
Minoru Sakurai ◽  
Hisashi Yamamoto
Keyword(s):  
Asymmetric Synthesis ◽  
Carbonyl Compounds
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