ChemInform Abstract: Mixed-ligand Complexes of Diruthenium(II, III): Syntheses and Molecular Structures of Chloro-bis-(acetato)-bis-(2-anilinopyridinato)(2-anilinopyridine)-diruthenium · methylene Chloride and Chloro-(acetato)-tris(6-chloro-2-oxypyridinat

1986 ◽  
Vol 17 (7) ◽  
Author(s):  
A. R. CHAKRAVARTY ◽  
F. A. COTTON
Keyword(s):  
Methylene Chloride ◽  
Mixed Ligand ◽  
Molecular Structures ◽  
Mixed Ligand Complexes

scholarly journals Synthesis And Characterization Of Mixed Ligand Complexes Of Co(Ii) And Fe(Iii) Ions With Maleic Acid And Heterocyclic Amines

2013 ◽  
Vol 25 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Md. Belayet Hossain ◽  
M Saidul Islam ◽  
M Rafiqul Islam ◽  
Md. Abdus Salam ◽  
M. Abu Yousuf
Keyword(s):  
Elemental Analysis ◽  
Maleic Acid ◽  
Chemical Society ◽  
Mixed Ligand ◽  
Molecular Structures ◽  
Heterocyclic Amines ◽  
Mixed Ligand Complexes ◽  
Synthesis And Characterization ◽  
Magnetic Studies

This paper describes the preparation and characterization of mixed ligand complexes of Co(II) and Fe(III) ions with maleic acid and heterocyclic amines of general formula [M(ME)L] and K[M(ME)L] (where M = Co(II) (1-4), Fe(III) (5-6); ME = C4H2O4 (1-4), 2C4H2O4 (5-6); L = C5H6N2 (1), C9H7N (2-3), C9H6NO (4), C5H5N.H2O (5), C6H7N (6)). The molecular structures of the complexes have been determined by spectral, magnetic studies and elemental analysis. Journal of Bangladesh Chemical Society, Vol. 25(2), 139-145, 2012 DOI: http://dx.doi.org/10.3329/jbcs.v25i2.15066

Molecular structures and redox properties of oxorhenium(V) ‘3+1’ mixed ligand complexes with heterocyclic thiolates containing nitrogen

2008 ◽  
Vol 361 (5) ◽  
pp. 1524-1529 ◽  
Author(s):  
Shubhamoy Chowdhury ◽  
Masanobu Nogami ◽  
Ali Canlier ◽  
Nobuyoshi Koshino ◽  
Yasuhisa Ikeda
Keyword(s):  
Mixed Ligand ◽  
Redox Properties ◽  
Molecular Structures ◽  
Mixed Ligand Complexes

Platinum(II) Mixed Ligand Complexes with Thiourea Derivatives, Dimethyl Sulphoxide and Chloride: Syntheses, Molecular Structures, and ESCA Data

2003 ◽  
Vol 629 (14) ◽  
pp. 2559-2565 ◽  
Author(s):  
Wilfredo Hernández ◽  
Evgenia Spodine ◽  
Rainer Richter ◽  
Karl-Heinz Hallmeier ◽  
Uwe Schröder ◽  
...  
Keyword(s):  
Mixed Ligand ◽  
Molecular Structures ◽  
Dimethyl Sulphoxide ◽  
Mixed Ligand Complexes ◽  
Thiourea Derivatives

scholarly journals Bioactivities of Novel Metal Complexes Involving B Vitamins and Glycine

2016 ◽  
Vol 14 (1) ◽  
pp. 287-298 ◽  
Author(s):  
Ahmed E. Fazary ◽  
Yi-Hsu Ju ◽  
Aisha Q. Rajhi ◽  
Ayed S. Alshihri ◽  
Mohammad Y. Alfaifi ◽  
...  
Keyword(s):  
Metal Ion ◽  
Antioxidant Activities ◽  
Mixed Ligand ◽  
Molecular Structures ◽  
Mixed Ligand Complexes ◽  
Elemental Analyses ◽  
Xrd Techniques ◽  
C Nmr ◽  
Secondary Ligand ◽  
Coordination Water

AbstractIn this work twelve novel mixed ligand complexes were synthesized. The complexes were formed between a metal ion (Cu(II), Cd(II), Mn(II), Fe(III), Ni(II), Pb(II)) and vitamins (B 3 and B 9) as primary ligands, and glycine as secondary ligand. Melting points, conductivities, and magnetic susceptibilities of the synthesized complexes were determined and the complexes were subjected to elemental analyses. The presence of coordination water molecules in the complex was also supported by TG/DTG thermal analysis. Full elucidation of the molecular structures for the synthesized mixed ligand complexes were confirmed using detailed spectroscopic IR, 1H-, 13C-NMR, and XRD techniques. In addition, cytotoxic and antioxidant activities of the twelve synthesized solid complexes were tested to evaluate their bioactivities.

Mixed ligand-metal Complexes of 2-(butan-2-ylidene) hydrazinecarbothioamide- Synthesis, Characterization, Computer Aided Drug Character Evaluation and in vitro Biological Activity Assessment

2019 ◽  
Vol 15 ◽  
Author(s):  
Tahmeena Khan ◽  
Rumana Ahmad ◽  
Iqbal Azad ◽  
Saman Raza ◽  
Seema Joshi ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Metal Complexes ◽  
Condensation Reaction ◽  
Dose Range ◽  
Biological Significance ◽  
Mixed Ligand ◽  
Binding Energies ◽  
Mixed Ligand Complexes ◽  
E Coli ◽  
Topo Ii

Background: Mixed ligand-metal complexes are efficient chelating agents because of flexible donor ability. Mixed ligand complexes containing hetero atoms sulphur, nitrogen and oxygen have been probed for their biological significance. Objective: Nine mixed ligand-metal complexes of 2-(butan-2-ylidene) hydrazinecarbothioamide (2-butanone thiosemicarbazone) and pyridine, bipyridine or 2-picoline as co-ligands were synthesized with Cu, Fe and Zn. The complexes were tested against MDA-MB231 (MDA) and A549 cell lines. Antibacterial activity was tested against S. aureus and E. coli. The drug character of the complexes was evaluated on several parameters viz. physicochemical properties, bioactivity scores, toxicity assessment and absorption, distribution, metabolism, excretion and toxicity (ADMET) profile assessment using various automated softwares. Molecular docking of the complexes was also performed with two target proteins. Method and Results: The mixed ligand-metal complexes were synthesized by condensation reaction for 4-5 h. The characterization was done by elemental analysis, 1H-NMR, FT-IR, molar conductance and UV spectroscopies. Molecular docking was performed against ribonucleotide reductase (RR) and topoisomerase II (topo II). [Cu(C5H11N3S)(py)2(CH3COO)2], [Zn(C5H11N3S)(bpy)(SO4)] and [Zn(C5H11N3S)(2-pic)2(SO4)] displayed the lowest binding energies with respect to RR. Against topo II [Cu(C5H11N3S)(py)2(CH3COO)2], [Cu(C5H11N3S)(bpy)(CH3COO)2] and [Zn(C5H11N3S)(2-pic)2(SO4)] had the lowest energies. The druglikness assessment was done using Leadlikeness and Lipinski’s rules. Against topo II [Cu(C5H11N3S)(py)2(CH3COO)2], [Cu(C5H11N3S)(bpy)(CH3COO)2] and [Zn(C5H11N3S)(2-pic)2(SO4)] had the lowest energies. Not more than two violations were obtained in case of each filtering rule showing drug like character of the mixed ligand complexes. Several of the complexes exhibited positive bioactivity scores and almost all the complexes were predicted to be safe with no hazardous effects. All the complexes were predicted to have no mutagenic character as shown by the Ames test [Zn(C5H11N3S)(py)2(SO4)] showed potential activity against MDA. [Co(C5H11N3S(bpy)(Cl)2] was also active against MDA. [Cu(C5H11N3S)(2-pic)2(CH3COO)2] also showed 27.6% cell viability at 100 µM against MDA. Against A549 [Co(C5H11N3S)(py)2(Cl)2], [Cu(C5H11N3S)(py)2(CH3COO)2] and [Co(C5H11N3S(bpy)(Cl)2] were active. [Co(C5H11N3S)(bpy)(Cl)2] and [Cu(C5H11N3S)(2-pic)2(CH3COO)2] were active against S. aureus. [Co(C5H11N3S)(2-pic)2(Cl)2] and [Zn(C5H11N3S)(2-pic)2(SO4)] were active at lower concentrations against S.aureus. Against E. coli, [Zn(C5H11N3S)(2-pic)2(SO4)] showed activity at 18-20mg dose range.

Interaction of ditertiary phosphines with phenyl- and 1-naphthyldithiocarbamatonickel(II)

1985 ◽  
Vol 50 (6) ◽  
pp. 1383-1390
Author(s):  
Aref A. M. Aly ◽  
Ahmed A. Mohamed ◽  
Mahmoud A. Mousa ◽  
Mohamed El-Shabasy
Keyword(s):  
Thermal Analysis ◽  
Powder Diffraction ◽  
Spin Structure ◽  
Magnetic Measurements ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
X Ray ◽  
Square Planar

The synthesis of the following mixed ligand complexes is reported: [Ni(phdtc)2(dpm)2], [Ni(phdtc)2(dpe)2], [Ni(phdtc)2(dpp)3], [Ni(1-naphdtc)2(dpm)2], [Ni(1-naphdtc)2], and [Ni(1-naphdtc)2(dpp)2], where phdtc = PhNHCSS-, 1-naphdtc = 1-NaPhNHCSS-, dpm = Ph2PCH2PPh2, dpe = Ph2P(CH2)2PPh2, and dpp = Ph2P(CH2)3PPh2. The complexes are characterised by microanalysis, IR and UV-Vis spectra, magnetic measurements, conductivity, X-ray powder diffraction, and thermal analysis. All the mixed ligand complexes are diamagnetic, and thus a square-planar or square-pyramidal (low-spin) structure was proposed for the present complexes.

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