ChemInform Abstract: NOVEL SYNTHESIS OF 5-(5-NITRO-2-FURYL)THIAZOLE DERIVATIVES

1985 ◽  
Vol 16 (29) ◽  
Author(s):  
G. D. KRAPIVIN ◽  
E. B. USOVA ◽  
V. G. KUL'NEVICH
Keyword(s):  
Thiazole Derivatives ◽  
Novel Synthesis

Novel Synthesis of 4-Bromo-3-oxo-2-phenylhydrazonobutyronitrile and 4-Cyano-3-oxo-2-phenylhydrazonobutyronitrile: Synthesis of Pyridazine, Thiazole, 1,2,4-Triazine and Pyrido[2,3-e]-1,2,4-triazine Derivatives

1992 ◽  
Vol 57 (8) ◽  
pp. 1758-1769 ◽  
Author(s):  
Rafat Milad Mohareb ◽  
Nadia Iskander Abdel-Sayed
Keyword(s):  
Thiazole Derivatives ◽  
Chemical Reagents ◽  
Novel Synthesis ◽  
Triazine Derivatives ◽  
Nucleophilic Reagents

4-Bromo-3-oxo-2-phenylhydrazono-butyronitrile (II) reacted with thioamides to afford the thiazole derivatives III and VI. Compound II reacted with nucleophilic reagents to afford XIIIa and XIIIb. The reactivity of XIIIa with some chemical reagents was studied to afford pyridazine, thiazole, 1,2,4-triazine derivatives.

scholarly journals Reaction of Carbon Disulfide with Cyanoacetic Acid Hydrazide: Novel Synthesis of Thiazole and Thiazolo[4,5-c]pyrazole

1999 ◽  
Vol 23 (1) ◽  
pp. 10-11
Author(s):  
Rafat M. Mohareb ◽  
Suzan I. Aziz ◽  
Nadia I. Abdel-Sayed ◽  
Ahmed H. El-Banna
Keyword(s):  
Carbon Disulfide ◽  
Acid Hydrazide ◽  
Cyanoacetic Acid ◽  
Thiazole Derivatives ◽  
Novel Synthesis ◽  
Cyanoacetic Acid Hydrazide

The reaction of cyanoacetic acid hydrazide with carbon disulfide in basic dimethylformamide afforded the potassium thiocarbamate 2 which underwent ready heterocyclization upon its reaction with α-haloketones to give the thiazole derivatives 4 and 23.

Design, Synthesis and Pharmacological Evaluation of New Thiazole Derivatives as Anthelmintic Agents

2020 ◽  
Vol 13 (5) ◽  
pp. 5075-5081
Author(s):  
Sirisha Kalam ◽  
Sai Krishn G ◽  
Kumara Swamy D ◽  
Sai Santhoshi K ◽  
Durga Prasad K
Keyword(s):  
Anthelmintic Activity ◽  
Docking Studies ◽  
Molecular Property ◽  
Thiazole Derivatives ◽  
Pharmacological Agents ◽  
Design Synthesis ◽  
Standard Drug ◽  
Lipinski’S Rule ◽  
Mass Spectral ◽  
Tubulin Protein

Pharmacological agents that kills parasites are essential drugs in some tropical countries. In this study, a series of 2-amino substituted 4-phenyl thiazole derivatives (4a-e) have been synthesized by the conventional method. The thiazole derivatives were synthesized by three steps. The obtained five derivatives were purified by recrystallization using methanol as a solvent or column chromatography. They were characterized by melting point, TLC, FTIR, 1H NMR and MASS spectral data. Compounds 4a-e were evaluated in silico by using different software’s (Lipinski’s Rule of 5, OSIRIS molecular property explorer, Molsoft molecular property explorer, and PASS & docking studies). These compounds were then evaluated for their possible anthelmintic activity against Indian adult earth worms (Pherituma postuma). All the compounds displayed significant anthelmintic activity. Compound 4c and 4e were more potent compounds when compared with the standard drug (mebendazole). Molecular docking studies guided and proved the biological activity against beta tubulin protein (1OJ0). In conclusions, these new molecules have promising potential as anthelmintic for treatment of parasites.   

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