ChemInform Abstract: Syntheses and Reactions of 3,4-Dihydro-2H-pyrans Bearing Trifluoromethyl Group.

1985 ◽  
Vol 16 (28) ◽  
Author(s):  
M. HOJO ◽  
R. MASUDA ◽  
E. OKADA
Keyword(s):  
Trifluoromethyl Group

Highly diastereo- and enantioselective organocatalytic synthesis of trifluoromethylated erythritols based on the in situ generation of unstable trifluoroacetaldehyde

2021 ◽  
Author(s):  
Kazumasa Funabiki ◽  
Toshiya Gotoh ◽  
Ryunosuke Kani ◽  
Toshiyasu Inuzuka ◽  
Yasuhiro Kubota
Keyword(s):  
Trifluoromethyl Group ◽  
In Situ Generation

A highly diastereo- and enantioselective organocatalytic method to synthesise erythritols bearing a trifluoromethyl group has been investigated.

Reducibility of the carbon-fluorine bond in the trifluoromethyl group

1996 ◽  
Vol 407 (1-2) ◽  
pp. 195-202 ◽  
Author(s):  
C. Combellas ◽  
F. Kanoufi ◽  
A. Thiébault
Keyword(s):  
Trifluoromethyl Group

Polyimide Copolymers Containing Various Levels Of The 6F Moiety For High Temperature And Microelectronic Applications

1991 ◽  
Vol 227 ◽  
Author(s):  
M. Haider ◽  
E. Chenevey ◽  
R. H. Vora ◽  
W. Cooper ◽  
M. Glick ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Temperature ◽  
Electrical Properties ◽  
Oxidative Stability ◽  
Trifluoromethyl Group ◽  
Thermal And Mechanical Properties

ABSTRACTTrifluoromethyl group-containing polyimides not only show extraordinary electrical properties, but they also exhibit excellent long-term thermo-oxidative stability. Among the most thermomechanically stable structural polyimides are those from 6F dianhydride (6FDA) and 6F diamines. The effects of substituting non-fluorine containing monomers such as BTDA, mPDA and 4,4′-DADPS for the hexafluoroisopropylidene monomers on the dielectric, thermo-oxidative, thermal and mechanical properties of the copolymers were studied.

ChemInform Abstract: Synthesis of Imidazo(4,5-c)pyridines with a Trifluoromethyl Group at C- 4 and/or C-6.

ChemInform ◽  
2010 ◽  
Vol 26 (12) ◽  
pp. no-no
Author(s):  
R. K. GAUTAM ◽  
S. FUJII ◽  
M. NISHIDA ◽  
H. KIMOTO ◽  
L. A. COHEN
Keyword(s):  
Trifluoromethyl Group

Fenfluramine (ponderax)

1965 ◽  
Vol 3 (9) ◽  
pp. 36-36
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Benzene Ring ◽  
Prolonged Treatment ◽  
Trifluoromethyl Group ◽  
Hypertensive Patients ◽  
The Central Nervous System ◽  
Main Distinguishing Feature

Fenfluramine (Ponderax - Selpharm) is a new appetite depressant, developed in France and introduced in Britain late in 1963. It is chemically related to amphetamine: its main distinguishing feature is a trifluoromethyl group attached to the benzene ring. The makers state that the drug does not stimulate the central nervous system, that it is not habit forming, and that it can be used by diabetics and hypertensive patients. They also state that it not only reduces the appetite, but also makes possible ‘prolonged treatment resulting in a true re-education of the appetite - which will persist after . . . ending . . . treatment’.

scholarly journals Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1342-1352 ◽  
Author(s):  
Javier Izquierdo ◽  
Atul Jain ◽  
Sarki Abdulkadir ◽  
Gary Schiltz
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biological Activities ◽  
Structural Complexity ◽  
Biologically Active ◽  
Coupling Reactions ◽  
Trifluoromethyl Group ◽  
Palladium Catalyzed ◽  
Active Natural

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF3), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

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