ChemInform Abstract: ENANTIOSPECIFIC TOTAL SYNTHESIS OF (-)-MEGAPHONE BY A HIGHLY CONTROLLED CONSECUTIVE 1,4- AND 1,3-ASYMMETRIC INDUCTION

1985 ◽  
Vol 16 (26) ◽  
Author(s):  
K. TOMIOKA ◽  
H. KAWASAKI ◽  
Y. IITAKA ◽  
K. KOGA
Keyword(s):  
Total Synthesis ◽  
Asymmetric Induction

ChemInform Abstract: Formal Total Synthesis of Fostriecin via 1,4-Asymmetric Induction Using Cobalt-Alkyne Complex.

ChemInform ◽  
2008 ◽  
Vol 39 (35) ◽  
Author(s):  
Yujiro Hayashi ◽  
Hirofumi Yamaguchi ◽  
Maya Toyoshima ◽  
Kotaro Okada ◽  
Takumi Toyo ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Asymmetric Induction

ChemInform Abstract: Asymmetric Induction by Sulfinyl Chirality. A Total Synthesis of (+)-Talaromycin A and (-)-Talaromycin B (I).

ChemInform ◽  
1987 ◽  
Vol 18 (51) ◽  
Author(s):  
C. IWATA ◽  
M. FUJITA ◽  
Y. MORITANI ◽  
K. HATTORI ◽  
T. IMANISHI
Keyword(s):  
Total Synthesis ◽  
Asymmetric Induction

1,3-Asymmetric induction in electrophilic addition onto homoallylsilanes. An approach towards the total synthesis of (+/−)-kumausyne

Tetrahedron ◽  
1997 ◽  
Vol 53 (8) ◽  
pp. 2835-2854 ◽  
Author(s):  
Oliver Andrey ◽  
Cécile Glanzmann ◽  
Yannick Landais ◽  
Liliana Parra-Rapado
Keyword(s):  
Total Synthesis ◽  
Electrophilic Addition ◽  
Asymmetric Induction

1,6-Asymmetric Induction in Boron-Mediated Aldol Reactions:  Application to a Practical Total Synthesis of (+)-Discodermolide

2003 ◽  
Vol 5 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Ian Paterson ◽  
Oscar Delgado ◽  
Gordon J. Florence ◽  
Isabelle Lyothier ◽  
Jeremy P. Scott ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Asymmetric Induction ◽  
Aldol Reactions

Asymmetric total synthesis of erythromcin. 1. Synthesis of an erythronolide A secoacid derivative via asymmetric induction

1981 ◽  
Vol 103 (11) ◽  
pp. 3210-3213 ◽  
Author(s):  
R. B. Woodward ◽  
E. Logusch ◽  
K. P. Nambiar ◽  
K. Sakan ◽  
D. E. Ward ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Asymmetric Induction ◽  
Asymmetric Total Synthesis

Total synthesis and establishment of the absolute stereochemistry of (+)-mostueine. Addition of chiral nucleophiles to 3,4-dihydro-2-methyl-9-(p-toluenesulfonyl)-β-carbolinium iodide

1992 ◽  
Vol 70 (12) ◽  
pp. 2922-2928 ◽  
Author(s):  
Allan W. Rey ◽  
Walter A. Szarek ◽  
David B. MacLean
Keyword(s):  
Total Synthesis ◽  
Indole Alkaloid ◽  
Optical Purity ◽  
Ring System ◽  
Asymmetric Induction ◽  
Iminium Salt ◽  
High Optical Purity ◽  
The Absolute ◽  
Absolute Stereochemistry ◽  
Mediated Reduction

A highly convergent synthesis of the pentacyclic indole alkaloid (+)-mostueine (1) is described. The key step involved the coupling of the dianion derived from (1′S)-3-(1′-hydroxyethyl)-4-methylpyridine (4) with the iminium salt 3,4-dihydro-2-methyl-9-(p-toluenesulfonyl)-β-carbolinium iodide (3). Low asymmetric induction (15% de) at the C-1 position of the β-carboline ring system (C-3 of mostueine) was obtained. The nonfermenting baker's yeast-mediated reduction of 3-acetyl-4-methylpyridine provided the hydroxyethylpyridine component in acceptable yield (67%) and high optical purity (99.0% ee). This synthesis of 1 has established that the absolute stereochemistry of mostueine is (3S, 19R).

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