ChemInform Abstract: ASYMMETRICAL SYNTHESIS OF (R)(-)- AND (S)(+)-ETILEFRINE BY ENANTIOSELECTIVE HYDROGENATION AND THE EFFECTS OF ENANTIOMERS IN AN ANIMAL EXPERIMENT

1985 ◽  
Vol 16 (19) ◽  
Author(s):  
H. KNORR ◽  
R. REICHL ◽  
W. TRAUNECKER ◽  
F. KNAPPEN ◽  
K. BRANDT
Keyword(s):  
Animal Experiment ◽  
Enantioselective Hydrogenation ◽  
Asymmetrical Synthesis

Urokinase Evaluated with the Experimental Radioactive Embolus

1967 ◽  
Vol 17 (03/04) ◽  
pp. 405-411
Author(s):  
M Hume
Keyword(s):  
Animal Experiment ◽  
Blood Clot ◽  
In Vitro Testing ◽  
Effective Agent

SummaryUrokinase and urokinase-activated plasmin have been given to the dog and rabbit. A thrombolytic state has been induced. Purified urokinase has induced lysis of the experimental radioactive blood clot embolus in the circulation. Demonstration of effectiveness in this animal experiment is hampered by inhibition of the agents in the circulation to a degree much greater than was noted in previous experiments with streptokinase. In vitro testing indicates that under proper conditions urokinase will be an effective agent in the treatment of human thromboembolism.

A thermoregulated phase transfer chiral Pt nanocatalyst for enantioselective hydrogenation of α-ketoesters

2020 ◽  
Vol 10 (23) ◽  
pp. 7824-7828
Author(s):  
Pu Chen ◽  
Yanhua Wang
Keyword(s):  
Phase Transfer ◽  
Enantioselective Hydrogenation

An efficient and recyclable thermoregulated phase transfer chiral Pt nanocatalyst was developed and applied to the enantioselective hydrogenation of α-ketoesters.

Effect of a Porous Suture Containing Transforming Growth Factor Beta 1 on Healing After Rotator Cuff Repair in a Rat Model

2021 ◽  
pp. 036354652110285
Author(s):  
Jong Pil Yoon ◽  
Hun-Min Kim ◽  
Jin-Hyun Choi ◽  
Hae Rim Kang ◽  
Dong Hyun Kim ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rat Model ◽  
Transforming Growth Factor Beta ◽  
Rotator Cuff Repair ◽  
Animal Experiment ◽  
Transforming Growth Factor ◽  
Group 3 ◽  
Growth Factor Beta ◽  
Cuff Repair ◽  
Tgf Β1

Background: The healing failure rate after rotator cuff repair is considerably high. Purpose: To evaluate the effect of a porous suture containing transforming growth factor beta 1 (TGF-β1) on the sustained release of TGF-β1 and rotator cuff healing in a rat model. Study Design: Controlled laboratory study. Methods: A porous suture was developed, and its tensile strength was measured. TGF-β1 was delivered using the porous suture, and a TGF-β1 release test and human fibroblast proliferation assay were performed. For the animal experiment, 30 rats were randomly allocated into 3 groups (n = 10 each). A bilateral supraspinatus tendon tear was made in all the rats, and repair was performed. Group 1 received repair only; group 2, repair and a single injection of TGF-β1; and group 3, repair using the porous suture containing TGF-β1. Eight weeks after repair, biomechanical and histological analyses were performed. Results: The porous suture was successfully developed with mechanical properties compatible with the conventional suture, and the sustained release of TGF-β1 from the porous suture was confirmed. In addition, the cell proliferation assay confirmed the biological safety of the porous suture. In the animal experiment, group 3 biomechanically exhibited the largest cross-sectional area and the highest ultimate failure load and ultimate stress (all P < .05). Histological examination revealed that group 3 showed significantly better collagen fiber density and tendon-to-bone maturation than did groups 1 and 2 (all P < .05). Conclusion: The porous suture containing TGF-β1 could sustainedly and safely release TGF-β1, and its use during rotator cuff repair could improve rotator cuff healing, as assessed on the basis of the biomechanical and histological changes in the rat model in this study. Considering the effectiveness, safety, and convenience of the porous suture without extra effort in surgery, the findings of the present study will have a far-reaching effect on the treatment of rotator cuff tears. Clinical Relevance: The porous suture containing TGF-β1 might improve healing after rotator cuff repair.

Iridium‐Catalyzed Enantioselective Hydrogenation of 3‐Substituted Isoquinolinium Salts

2021 ◽  
Author(s):  
Bin Li ◽  
Jiaxin Wang ◽  
Xiaoye Li ◽  
Jiayue Xi ◽  
Ruoxuan Wang ◽  
...  
Keyword(s):  
Enantioselective Hydrogenation
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